A5061144122- Health, Environment, Cognitive Aging
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Nutritional Studies and Diet
- Parkinson's Disease Mechanisms and Treatments
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Computational Drug Discovery Methods
- Environmental Justice and Health Disparities
- Olfactory and Sensory Function Studies
- Neonatal Respiratory Health Research
- Genetics, Bioinformatics, and Biomedical Research
- Cerebral Palsy and Movement Disorders
- Pediatric health and respiratory diseases
- Malaria Research and Control
- Frailty in Older Adults
- Epigenetics and DNA Methylation
- Delphi Technique in Research
- Computational Physics and Python Applications
- Botulinum Toxin and Related Neurological Disorders
- Infant Health and Development
- Scientific Computing and Data Management
- Neurological disorders and treatments
- Health Policy Implementation Science
University of Michigan–Ann Arbor
2017-2025
Harvard University
2021-2025
University of California, San Francisco
2015-2024
Oxford University Clinical Research Unit
2023
Dignity Health
2020
University Memory and Aging Center
2019
Michigan United
2018
Hudson Institute of Medical Research
2017
Monash University
2017
Stark racial disparities in disease incidence among American women remain a persistent public health challenge. These likely result from complex interactions between genetic, social, lifestyle, and environmental risk factors. The influence of factors, such as chemical exposure, however, may be substantial is poorly understood. We quantitatively evaluated chemical-exposure by race/ethnicity, life stage, time United States (US) (n = 38,080) using biomarker data for 143 chemicals the National...
Abstract Background Some hormonally active cancers have low survival rates, but a large proportion of their incidence remains unexplained. Endocrine disrupting chemicals may affect hormone pathways in the pathology these cancers. Objective To evaluate cross-sectional associations between per- and polyfluoroalkyl substances (PFAS), phenols, parabens self-reported previous cancer diagnoses National Health Nutrition Examination Survey (NHANES). Methods We extracted concentrations 7 PFAS 12...
Saliva is a widely used biological sample, especially in pediatric research, containing heterogenous mixture of immune and epithelial cells. Associations exposure or disease with saliva DNA methylation can be influenced by cell-type proportions. Here, we developed reference panel to estimate interindividual heterogeneity whole studies. was collected from 22 children (7–16 years) sorted into cells, using size exclusion filtration magnetic bead sorting. measured the Illumina MethylationEPIC...
The National Health and Nutrition Examination Survey (NHANES) provides data on the health environmental exposure of non-institutionalized US population. Such have considerable potential to understand how environment behaviors impact human health. These are also currently leveraged answer public questions such as prevalence disease. However, these need first be processed before new insights can derived through large-scale analyses. NHANES stored across hundreds files with multiple...
Phthalates with potential adverse health effects are being replaced by other phthalates or phthalate alternatives. Little is known about temporal trends of exposure in pregnant women the United States. We quantified 16 metabolites eight and di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) 656 urine samples collected from 192 California 2007–2013 during their second third trimesters pregnancy who participated MARBLES (Markers Autism Risk Babies—Learning Early Signs) study. used multiple...
BACKGROUND: Recent developments in technologies have offered opportunities to measure the exposome with unprecedented accuracy and scale.However, because most investigations targeted only a few exposures at time, it is hypothesized that majority of environmental determinants chronic diseases remain unknown.OBJECTIVES: We describe functional concept explain how can leverage existing bioassays high-resolution mass spectrometry for exploratory study.We discuss such an approach address...
There is a suite of chemicals, including metals, pesticides, and personal care product compounds, which are commonly detected at high levels in US Center for Disease Control's National Health Nutrition Examination Survey (NHANES) chemical biomarker screens. Whether these chemicals influence development breast cancer not well understood.
Abstract Neurodegenerative diseases pose increasing challenges to global aging populations. Cognitive decline in older adults is an initial indicator of neurodegenerative diseases, yet comprehensive research on environmental chemical exposures related cognitive limited. This study uses Exposome-Wide Association Study (ExWAS) framework investigate associations chemicals with function individuals aged ≥60 years. We used the Digit Symbol Substitution Test (DSST) scores and biomarker data US...
Abstract Cognitive impairment among older adults is a growing public health challenge and environmental chemicals may be modifiable risk factors. A wide array of has not yet been tested for association with cognition in an environment-wide framework. In the US National Health Nutrition Examination Survey (NHANES) 1999 - 2000 2011 2014 cross-sectional cycles, was assessed using Digit Symbol Substitution Test (DSST, scores 0 117) participants aged 60 years older. Concentrations measured blood...
Environmental chemical exposures influence immune system functions, and humans are exposed to a wide range of chemicals, termed the "exposome". A comprehensive, discovery analysis associations multiple families with biomarkers is needed. In this study, we tested between environmental concentrations biomarkers. We analyzed United States cross-sectional National Health Nutrition Examination Survey (NHANES 1999-2018). Chemical biomarker were measured in blood or urine (196 17 families). Immune...
Artemether-lumefantrine is a first-line regimen for the treatment of uncomplicated malaria during second and third trimesters pregnancy. Previous studies have reported changes in pharmacokinetics clinical outcomes following with artemether-lumefantrine pregnant women compared to nonpregnant adults; however, results are inconclusive. We conducted study rural Uganda compare responses between 30 adults Plasmodium falciparum malaria. All participants were uninfected HIV, treated six-dose...
Occupational exposures to toxicants are estimated cause over 370 000 premature deaths annually. The risks due multiple workplace chemical and those occupations most susceptible the resulting health effects remain poorly characterized. aim of this study is identify with elevated toxicant biomarker concentrations increased risk associated in a diverse working US population. For observational 51 008 participants, we used data from 1999-2014 National Health Nutrition Examination Survey. We...
Abstract Quantification of motor symptom progression in Parkinson’s disease (PD) patients is crucial for assessing and optimizing therapeutic interventions, such as dopaminergic medications deep brain stimulation. Cumulative heuristic clinical experience has identified various signs associated with PD severity, but these are neither objectively quantifiable nor robustly validated. Video-based objective quantification enabled by machine learning (ML) introduces a potential solution. However,...
Abstract Understanding the combined effects of risk factors on all-cause mortality is crucial for implementing effective stratification and designing targeted interventions, but such are understudied. We aim to use survival-tree based machine learning models as more flexible nonparametric techniques examine multiple physiological mortality. More specifically, we (1) study between mortality, (2) identify five most influential visualize their influence (3) compare cut-offs with current...
Chemical biomarker concentrations are driven by complex interactions between chemical use patterns, exposure pathways, and toxicokinetic parameters such as biological half-lives. Criteria to differentiate legacy from current exposures helpful for interpreting variation in age-based time trends of identifying chemicals which children highly exposed. A systematic approach is needed study temporal a wide range the US population. Using National Health Nutrition Examination Survey (NHANES) data...
Mortality risk stratification based on dichotomising a physiological indicator with cutoff point might not adequately capture increased mortality and account for non-linear associations. We aimed to characterise the linear relationships of 27 indicators all-cause evaluate whether current clinical thresholds are suitable in distinguishing patients at high from those low risk.
Billions of dollars are spent on environmental dredging (ED) to remediate contaminated sediments, with one goal being reduced human health risks. However, ED may increase risks in unanticipated ways, thus potentially reducing net benefits.To assess the ways that benefits, we quantitatively assessed a subset population benefits and ED, using 2009-2015 remediation Hudson River Polychlorinated Biphenyls (PCBs) Superfund Site as case study. Three scenarios were evaluated: No Action (NA), Source...
Background: The choice of malaria treatment for HIV-infected pregnant women receiving efavirenz-based antiretroviral therapy must consider the potential impact drug interactions on antimalarial exposure and clinical response. aim this study was to investigate effects efavirenz artemether–lumefantrine (AL) because no studies have isolated women. Methods: A prospective pharmacokinetic (PK) compared HIV-infected, efavirenz-treated with HIV-uninfected in Tororo, Uganda. All received standard...
CYP3A5 and CYP3A4 are the predominant enzymes responsible for tacrolimus metabolism; however only a proportion of population expresses secondary to genetic variation. is expressed in both intestine liver has been shown impact bioavailability metabolism orally administered tacrolimus. Increasing initial dose by 50% 100% recommended patients who known expressers; however, whether this adjustment appropriate i.v. administration unclear. The objective study was evaluate genotype as well other...
Abstract Background Stark racial disparities in disease incidence among American women remains a persistent public health challenge. These likely result from complex interactions between genetic, social, lifestyle, and environmental risk factors. The influence of factors, such as chemical exposure, however, may be substantial is poorly understood. Objectives We quantitatively evaluated chemical-exposure by race/ethnicity age United States (US) using biomarker data for 143 chemicals the...
Abstract Mechanical ventilation of preterm neonates causes lung inflammation and injury, with potential life-long consequences. Inert 50-nm polystyrene nanoparticles (PS50G) reduce allergic in the lungs adult mice. We aimed to confirm anti-inflammatory effects PS50G a sheep asthma model, investigate prophylactic administration on ventilation-induced injury (VILI) lambs. assessed inflammatory cell infiltration, without PS50G, after airway allergen challenge ewes sensitised house dust mite....
We are bioinformatics trainees at the University of Michigan who started a local chapter Girls Who Code to provide fun and supportive environment for high school women learn power coding. Our goal was cover basic coding topics data science concepts through live hands-on practice. However, we could not find resource that exactly met our needs. Therefore, over past three years, have developed curriculum instructional format using Jupyter notebooks effectively teach introductory Python science....
Modern diets are largely comprised of mixed dishes, a mixture different ingredients with varying proportions. Environmental impacts dishes not well studied since most research focuses on associated single-component food items (e.g. beef, milk etc.). We explore methods to deconstruct into “basic components” in order estimate their environmental footprints by using case study investigating the carbon footprint pizza US diet, aiming identify strengths and limitations each approach. determined...