A5073182776- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Diabetes Management and Education
- Physical Activity and Health
- Mobile Health and mHealth Applications
- Blood properties and coagulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetic Foot Ulcer Assessment and Management
- Primary Care and Health Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Chronic Disease Management Strategies
- Urban Green Space and Health
- Innovations in Medical Education
- Biosimilars and Bioanalytical Methods
- Food composition and properties
- Vitamin C and Antioxidants Research
- Advanced Glycation End Products research
- Antiplatelet Therapy and Cardiovascular Diseases
- Telemedicine and Telehealth Implementation
- Nitric Oxide and Endothelin Effects
University of the Highlands and Islands
2013-2024
NHS Highland
2009-2021
Raigmore Hospital
2013-2021
Diabetes Australia
2021
Prevention of Organ Failure
2021
Executive Office of the President
2010-2018
Highland Community College - Illinois
2016-2017
University of Manitoba
2013
Millennium Institute
2010
University of Dundee
2001
Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans renal function diabetes.Using serum samples from 818 adults who were considered to have extreme annual loss estimated glomerular filtration rate (eGFR; i.e., slope) based retrospective clinical records, among 6,127 the Scottish Diabetes Research Network Type Bioresource...
The objective of this cross-sectional study was to explore the relationship detectable C-peptide secretion in type 1 diabetes clinical features and genetic architecture diabetes. measured an untimed serum sample SDRNT1BIO cohort 6076 Scottish people with clinically diagnosed or latent autoimmune adulthood. Risk scores at loci previously associated 2 were calculated from publicly available summary statistics. Prevalence varied 19% those onset before age 15 duration greater than years 92%...
Digital games are an important class of eHealth interventions in diabetes, made possible by the Internet and a good range affordable mobile devices (eg, phones tablets) available to consumers these days. Gamifying disease management can help children, adolescents, adults with diabetes better cope their lifelong condition. Gamification social in-game components used motivate players/patients positively change behavior lifestyle. In this paper, we start presenting main challenges facing people...
To evaluate differences in HbA1c concentrations between centers and to assess the factors associated with glycemic control young people type 1 diabetes Scotland.Data on 1,755 patients (94% of those registered) were collected from 18 providing care children <15 years age. At every clinic visit, a duplicate sample was measured reference laboratory, clinical information prospectively.Average concentration 9.1% (range 5.0-15.0). The following significant associations level identified: age,...
This study investigated whether oral candida infection in diabetics and adhesion of Candida albicans to buccal epithelial cells vitro were related. Buccal from 50 patients with diabetes mellitus showed a significant increase C. strain CDS 88 compared those collected non-diabetic controls matched for age, sex denture status. Oral carriage, secretor status also both groups. The frequency carriage was increased, but not significantly, there significantly higher incidence diabetic controls....
Abstract Aims/hypothesis We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression type 1 diabetes beyond prior eGFR, comparing their performance with urinary albumin/creatinine ratio (ACR). Methods From population-representative Scottish Diabetes Research Network Type Bioresource (SDRNT1BIO) we sampled 50% and 25% those starting eGFR below above 75 ml min −1 [1.73 m] −2 , respectively ( N = 1629), median 5.1 years follow-up....
Abstract Background Platelet hyperaggregability is a pro-thrombotic feature of type-2 diabetes, associated with low levels the antioxidant glutathione (GSH). Clinical delivery N -acetylcysteine (NAC), biosynthetic precursor GSH, may help redress GSH shortfall in platelets, thereby reducing thrombotic risk diabetes patients. We investigated effect NAC vitro , at concentrations attainable tolerable oral dosing, on platelet and aggregation propensity blood from patients diabetes. Methods Blood...
Phagocytic function was assessed by serial whole blood chemiluminescence in poorly controlled type 2 (non-insulin dependent) diabetic patients during efforts to improve glycaemic control and compared with a group of well 1 (insulin patients. Chemiluminescence (corrected standard polymorphonuclear count) remained below normal (0.15-0.30 photons/second/cell) for most the until 12 weeks when value significantly increased showing improved (mean (range) 0.25 (0.01-0.43) those no improvement...
N-Acetylcysteine (NAC) is a frequently used "antioxidant" in vitro, but the concentrations applied rarely correlate with those encountered oral dosing vivo. Here, we investigated vitro antioxidant and antiplatelet properties of NAC at (10-100 μM) that are achievable plasma tolerable dosing. The impact pretreatment (2 hours) on aggregation platelets from healthy volunteers response to thrombin adenosine diphosphate platelet-derived nitric oxide (NO) was examined. found be weak reducing agent...
Abstract Aims In the UK , lifestyle intervention is first‐line management in Type 2 diabetes. It unclear what type of diet most efficacious for improving glycaemic control. This study investigated effects an oat‐enriched on control, postprandial glycaemia, inflammation and oxidative stress compared with standard dietary advice. Methods a randomized crossover design, 27 volunteers diabetes, managed only, were observed two consecutive 8‐week periods following either or re‐enforced Volunteers...
The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels the antioxidant, glutathione (GSH), and reduces platelet–monocyte conjugation in blood from patients type 2 diabetes. In placebo-controlled randomised crossover study, effect NAC on GSH investigated diabetes (eligibility criteria: men or post-menopausal women well-controlled (HbA1c < 10%), not aspirin statins). Patients (n = 14; age range 43–79 years, HbA1c 6.9 ± 0.9% [52.3...
Scope Inflammatory status can increase the risk of adverse cardiovascular events linked to platelet activity and involvement microparticles (MP) released from platelets (PMP), leukocytes (LMP), monocytes (MMP). These MP carry host cell-derived antigens that may act as markers metabolic health. Subjects newly diagnosed with type 2 diabetes are offered appropriate standard dietary advice (SDA) but this not be optimal specific inclusion other nutrients, such oats, add benefit. The effectiveness...
To assess the clinical performance and patient acceptance of HemaSpot™ blood collection devices as an alternative method.Adult men women with any type diabetes, routinely carrying out self-monitoring glucose were recruited (n = 128). Participants provided a venous sample prepared two HemaSpot dried spots, one at clinics home. HbA1c analysis was by Tosoh G8 high-performance liquid chromatography. also completed questionnaire.Strong linear relationships been levels in spots observed model...
There is a lack of research into green exercise which investigates and compares motivational drivers between the different types outdoor activities. The current paper addressed this gap by classifying comparing three exercise: (i) Recreational physical activity, (ii) competitive sport, (iii) adventure sport. Using mixed methodological approach, present study investigated motivations for adhering to directly compared differences these forms exercise. Online questionnaires face-to-face...
Abstract Aims/hypothesis The aim of this study was to provide data from a contemporary population-representative cohort on rates and predictors renal decline in type 1 diabetes. Methods We used 5777 people with diabetes aged 16 older, diagnosed before the age 50, representative adult population Scotland (Scottish Diabetes Research Network Type Bioresource; SDRNT1BIO). measured serum creatinine urinary albumin/creatinine ratio (ACR) at recruitment linked national electronic healthcare...
Increased free radical activity in diabetes mellitus may contribute to the higher prevalence and mortality from macrovascular disease diabetic patients. To investigate this, levels of plasma antioxidants (superoxide dismutase, caeruloplasmin, plasma, lysate thiol), diene conjugates, lipid peroxides, chemiluminescence were measured non‐diabetic patients with peripheral vascular compared healthy control subjects. Caeruloplasmin, conjugate ratio, peroxides significantly increased but there was...
There are conflicting views in the literature as to whether cannabinoids have an impact on platelet activity and what extent cannabinoid receptors involved. This is important issue resolve because effects of putative therapeutic inhibitors stimulators will their potential benefits safety.The data presented this manuscript clearly show that endocannabinoid 2-arrachidonyl glycerol can activate activity, but mediated through aspirin-sensitive pathway not affected by receptor antagonists or FAAH...