A5038552816- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Robotics and Sensor-Based Localization
- Pharmacology and Obesity Treatment
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Target Tracking and Data Fusion in Sensor Networks
- Neuropeptides and Animal Physiology
- Chronic Myeloid Leukemia Treatments
- Thermoregulation and physiological responses
- Body Composition Measurement Techniques
- Indoor and Outdoor Localization Technologies
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Bone health and treatments
- Inertial Sensor and Navigation
- Regulation of Appetite and Obesity
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Birth, Development, and Health
- Neuroendocrine Tumor Research Advances
- Blood Pressure and Hypertension Studies
- Bariatric Surgery and Outcomes
University of Klagenfurt
2019-2025
Berufsverband der Frauenärzte
2023
BMW (Germany)
2022
Technische Universität Dresden
2007-2018
University Hospital Carl Gustav Carus
2008-2018
Institute of Experimental Physics of the Slovak Academy of Sciences
2015
Ninewells Hospital
1997-2009
University of Dundee
1991-2009
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2008
NHS Tayside
2004-2007
In patients with Parkinson's disease (PD), the associated pathology follows a characteristic pattern involving inter alia enteric nervous system (ENS), dorsal motor nucleus of vagus (DMV), intermediolateral spinal cord and substantia nigra, providing basis for neuropathological staging disease. Here we report that intragastrically administered rotenone, commonly used pesticide inhibits Complex I mitochondrial respiratory chain, is able to reproduce PD pathological as found in patients. Our...
For patients on T(4) replacement, the dose is guided by serum TSH concentrations, but some request higher doses due to adverse symptoms.The aim of study was determine safety having a low not suppressed when receiving long-term replacement.We conducted an observational cohort study, using data linkage from regional datasets between 1993 and 2001.A population-based all in Tayside, Scotland, performed.All taking replacement therapy (n = 17,684) were included.Fatal nonfatal endpoints considered...
Bombesin, a peptide with widespread biological actions, has been demonstrated in human tissues by immunological methods. To investigate its effect man, synthetic bombesin was infused at low doses six male volunteers. Bombesin 2.4 pmol kg−1 min−11 produced significant rises plasma insulin, glucagon, pancreatic polypeptide, gastrin, cholecystokinin, motilin, glucose-dependent insulinotropic neurotensin, enteroglucagon, vasoactive intestinal and serum calcium. In contrast, caused profound fall...
The effect of dieting on blood pressure and catecholamine metabolism was assessed in 11 normotensive obese women by providing first a weight-maintenance regimen high carbohydrate then low-energy diet. All dietary constituents other than were maintained constant throughout the 18-day study. low-carbohydrate diet led within 48 hours to 41% fall urinary output 4-hydroxy-3-methoxy mandelate significant systolic diastolic pressure. Plasma noradrenaline concentrations also fell hypotensive...
The objective of this study was to define the level treated thyroid dysfunction in a complete and representative population base an area sufficient dietary iodine intake. We used record-linkage technology retrospectively identify subjects for hyperthyroidism or hypothyroidism general Tayside, Scotland from 1 January 1993 30 April 1997. Thyroid status ascertained by record linkage patient-level datasets containing details treatments hypothyroidism. identified 620 incident cases...
1. The thermogenic response and changes in plasma substrates hormones were tested after a liquid meal lean, obese formerly women. 2. Subjects with family history of obesity either while or slimming to normal weight had response, which was only half that the lean group. 3. immediate glucose insulin greater subjects, but sustained circulating did not differ three groups. Thyroidal hormone concentrations alter postprandially: venous noradrenaline levels rose groups only. 4. differences...
Summary Objective We aimed to describe the changing incidence of thyroid disease in a population‐based study Tayside, Scotland (population 390 000) between 1994 and 2001. Design A retrospective, data‐linkage, measuring prevalence disease. Patients All patients with newly diagnosed, treated stable Tayside were identified by electronic linkage six datasets, including all regional biochemistry data, hospital admissions, deaths follow‐up register. Results The overall dysfunction has increased...
The effect of insulin on leg and whole body protein turnover was determined by exchange plasma kinetics [15N]phenylalanine [1-13C]leucine during amino acid (AA) sufficiency. Eight healthy subjects were studied AA infusion alone glucose (0.29 nmol.m-2.min-1) with additional AA. Insulin strongly stimulated the positive balance seen (AA alone, 2.6 +/- 6.1 vs. + AA, 33.1 5.8 nmol phenylalanine . 100 g leg-1.min-1; P less than 0.001). Phenylalanine uptake tissues rose plus (47.3 11.5 73.1 7.3...
OBJECTIVE There are few U.K. data on the incidence rates of amputation in diabetic subjects compared with nondiabetic population. RESEARCH DESIGN AND METHODS We performed a historical cohort study first lower-extremity amputations based Tayside, Scotland (population 364,880) from 1 January 1993 to 31 December 1994. The Diabetes Audit and Research Tayside (DARTS) database was used identify prevalence 7,079 patients 1993. estimated age-specific standardized lower-limb cohorts. Results were...
Abstract Context: There are limited studies describing mortality and morbidity in patients treated for hyperthyroidism, no data exist people with hypothyroidism. Objective: The objective of the study was to describe all-cause vascular after treatment hyperthyroidism Design: This a population-based cohort from 1994 2001. Setting: conducted Tayside, Scotland. Patients: All were thyroid dysfunction. Intervention(s): Event rates among dysfunction compared general population. We measured...
Summary OBJECTIVE Patients on l ‐thyroxine with a ‘suppressed’ TSH (< 0 05 mU/l) were compared to those in whom was detectable but not elevated (0 05– 4 mU/l), regard morbidity data. DESIGN Biochemical data from Tayside Thyroid Register matched hospital admissions obtained Health Board Statistics. PATIENTS The patients identified registered the computerized Register. MEASUREMENTS Serum T4 and assays, clinical assessment scores, admission records ischaemic heart disease, overall fractures,...
Purpose: To examine the biomechanical effect and UVA-absorption of a riboflavin/UVA cross-linking method, which suggests leaving epithelium intact applying benzalkonium chloride (BAC) on rabbits' corneas.Methods: In total, 32 eyes from 16 rabbits were divided into 4 groups. Group 1 was treated with without BAC. groups 2 3, left hypoosmolar solution riboflavin that contained BAC 0.02% or 0.04% used. according to standard protocol mechanical debridement epithelium. After treatment both eyes,...
1. The metabolic response of lean and obese women to caffeine was studied see if could be used demonstrate the subnormal thermogenesis in obesity previously shown after standard meals or intravenous infusions noradrenaline. 2. rise resting rate with similar groups β-adrenoceptor blockade did not reduce increment either group. These responses not, therefore, correspond other thermogenic constitutionally obese. 3. In a post-obese group, i.e. who were now normal weight, there reduced caffeine....
Small drones that navigate using cameras may be limited in their speed and agility by low onboard computing power. We evaluate the role of edge 5G for such autonomous navigation. The offloading image processing tasks to an server is studied with a vision-based navigation algorithm. Three computation modes are compared: onboard, fully offloaded edge, partially offloaded. Partial expected pose lower demands on communication network terms transfer rate than full but requires some processing....
To evaluate differences in HbA1c concentrations between centers and to assess the factors associated with glycemic control young people type 1 diabetes Scotland.Data on 1,755 patients (94% of those registered) were collected from 18 providing care children <15 years age. At every clinic visit, a duplicate sample was measured reference laboratory, clinical information prospectively.Average concentration 9.1% (range 5.0-15.0). The following significant associations level identified: age,...
The aldosterone-to-renin ratio (ARR) is a marker of aldosterone activity in hypertension. We examined the relationship ARR to distribution two biallelic polymorphisms at CYP11B2 gene locus. One polymorphism affects putative steroidogenic factor-1 binding site (−344 T/C) 5′-regulatory region, whereas other reflects replacement intron-2 from with that neighboring encoding 11β-hydroxylase (CYP11B1; wild-type/conversion). studied consecutive referrals Tayside hypertension clinic 1998. Because...
A double blind placebo controlled study was carried out in 40 subjects newly referred for treatment obesity to determine the effects of new thermogenic β adrenoceptor agonist BRL 26830A. The were randomised receive either 26830A, 200 mg daily two weeks then 400 daily, or 18 weeks, and all instructed follow a 3·35 MJ diet that low fat high fibre. Weight loss 15·4 (SD 6·6) kg given 26830A compared with 10·0 (5·9) those (p=0·02). relative weight 0·93 (0·39)% week 0·61 (0·38)% Urinary excretion...
OBJECTIVE To evaluate the association between use of ACE inhibitors and hospital admission for severe hypoglycemia to explore effects potential confounding variables on this relationship. RESEARCH DESIGN AND METHODS The incidence is controversial. A recent study reported that 14% all admissions might be attributable inhibitors. We performed a nested case-control study, using cohort 6,649 diabetic patients taking insulin or oral antidiabetic drugs, Diabetes Audit Research in Tayside, Scotland...