A5102749823- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Cancer Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Ophthalmology and Eye Disorders
- Hormonal Regulation and Hypertension
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Diabetes Management and Research
- Diet and metabolism studies
- Myasthenia Gravis and Thymoma
- Neuroblastoma Research and Treatments
- Diabetes Management and Education
- Cancer, Hypoxia, and Metabolism
- Diabetes Treatment and Management
- Neuroendocrine Tumor Research Advances
- Food composition and properties
- Biomedical Text Mining and Ontologies
- Chronic Disease Management Strategies
- Cardiovascular Disease and Adiposity
- Diabetes and associated disorders
- Restraint-Related Deaths
- Medical Imaging Techniques and Applications
Aberdeen Royal Infirmary
2011-2025
Chelsea and Westminster Hospital
2024
Ninewells Hospital
2024
NHS Grampian
2005-2024
University of Aberdeen
2020
Cambridge University Press
2015
New York University Press
2015
Royal Hallamshire Hospital
2009
Sheffield Teaching Hospitals NHS Foundation Trust
2009
Abstract Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting to clinical characteristics AIPmut AIPneg patients. Design 12-year prospective, observational study. Participants & Setting We studied probands...
Abstract Objective The optimal approach to the surveillance of non-functioning pituitary microadenomas (micro-NFPAs) is not clearly established. Our aim was generate evidence on natural history micro-NFPAs support patient care. Design Multi-centre, retrospective, cohort study involving 23 endocrine departments (UK NFPA consortium). Methods Clinical, imaging, and hormonal data micro-NFPA cases between January, 1, 2008 December, 21, 2021 were analysed. Results Data for 459 patients retrieved...
Summary Background A survey of physicians’ practice relating to radioiodine administration for hyperthyroidism was carried out in the UK over 15 years ago and showed wide variations patient management. This led development national guidelines use hyperthyroidism. As there have been significant advances field since that survey, we another study prevalent practices therapy benign thyroid disorders across UK. Subjects methods We mailed 698 consultant endocrinologists a questionnaire on...
Abstract: Radioiodine, antithyroid drugs and surgery have been well established therapies for Graves' hyperthyroidism several decades. However there remain large variations in practice among physicians the preferred modality method of administration. Patient choice perceptions also play a big role treatment. Radioiodine may be given using fixed high doses or by calculated following uptake studies. The risks radioiodine including eye disease prophylactic steroid therapy are discussed....
Abstract Aims In the UK , lifestyle intervention is first‐line management in Type 2 diabetes. It unclear what type of diet most efficacious for improving glycaemic control. This study investigated effects an oat‐enriched on control, postprandial glycaemia, inflammation and oxidative stress compared with standard dietary advice. Methods a randomized crossover design, 27 volunteers diabetes, managed only, were observed two consecutive 8‐week periods following either or re‐enforced Volunteers...
Scope Inflammatory status can increase the risk of adverse cardiovascular events linked to platelet activity and involvement microparticles (MP) released from platelets (PMP), leukocytes (LMP), monocytes (MMP). These MP carry host cell-derived antigens that may act as markers metabolic health. Subjects newly diagnosed with type 2 diabetes are offered appropriate standard dietary advice (SDA) but this not be optimal specific inclusion other nutrients, such oats, add benefit. The effectiveness...
Surveillance is often adopted for asymptomatic non-functioning pituitary macroadenomas (macroNFPAs). Due to low quality evidence, uncertainty remains on optimal frequency of imaging/biochemical monitoring and indications surgery. We assessed the natural history outcomes patients with macroNFPA who had as initial management choice from UK NFPA Consortium. Multicentre, retrospective, cohort study involving 21 endocrine departments. Clinical, imaging, hormonal data 949 followed-up between...
This study determined the cost effectiveness of treating thyrotoxicosis using thionamide therapy, radioiodine or surgery in United Kingdom.One hundred thirty-five patients diagnosed with (62% Graves' disease, 7% nodular 5% thyroiditis, and 27% unknown aetiology) referred 12 months were offered a fully informed choice treatment modality. Thirteen transient subsequently excluded from analysis. Seventy-four (61%) received an 18-month course 43 therapy (35%), 5 had thyroidectomy (4%) within...
Background: While few hypothyroid patients require more than the expected weight-related dose of levothyroxine, underlying causes larger-than-expected dosing requirements have not been studied in a single cohort. Our aim was to determine and quantify multiple factors contributing high-dose levothyroxine cohort with hypothyroidism. Methods: The Grampian Automated Follow-Up Register (GAFUR) monitors around 17,500 patients. In 2008, 190 (1%) took >225 μg daily. A questionnaire sent 174 (16 were...
Summary The new European Society of Endocrinology guidelines on the management adrenal incidentalomas suggest discussion in a multidisciplinary meeting and consideration additional imaging for homogenous lesions with density >20 Hounsfield units (HU) size <4 cm. We report case 29-year-old woman who presented benign-looking lesion CT adrenals based washout values, which was diagnosed as malignant subsequent imaging. Initial hormonal work-up normal. Two years later, had grown to 17 × 11...
ABSTRACT Background Recent years have seen changes and uncertainties in evidence guideline recommendations Graves' disease treatment. To understand the impact of these developments on current practice, we undertook a survey management United Kingdom compared this to other national international surveys. Method Members British Thyroid Association, UK Society for Endocrinology regional endocrinology networks, were invited by e‐mail complete 15‐min online (October 2022 March 2023). Results Out...
Adrenal phaeochromocytoma rarely causes ectopic ACTH syndrome. We describe a 44-yr-old hypertensive woman who was Cushingoid and markedly pigmented. Laboratory studies indicated severe hypokalaemia, abnormal liver function tests, random serum cortisols greater than 1660 nmol/L. Urinary catecholamines were increased. An abdominal computed tomography scan showed 4-cm left adrenal mass an hypertrophied right adrenal. levels elevated at 200 pmol/L, but precursors, which cross-react in the assay,...
Abstract Severe hypercalcaemia during pregnancy is rare and most cases are secondary to hyperparathyroidism. This the first report of a parathyroid hormone related protein (PTHrP) secreting neuroendocrine tumour pancreas manifesting with severe pregnancy. Measurement PTHrP was useful in both diagnosis follow up our patient should be considered diagnostic workup patients unexplained hypercalcaemia. A raised concentration strong indicator malignancy.
Abstract The effects of fish oil (FO) supplementation on glycaemic control are unclear, and positive may occur only when the phospholipid content tissue membranes exceeds 14 % as n -3 PUFA. Subjects ( 36, thirty-three completed) were paired based metabolic parameters allocated into a parallel double-blind randomised trial with one each pair offered daily either 6 g FO (3·9 PUFA) or maize (MO) for 9 months. Hyperinsulinaemic–euglycaemic–euaminoacidaemic (HIEGEAA) clamps (with [6,6 2 H...
Thyroid status in the months following radioiodine (RI) treatment for Graves' disease can be unstable. Our objective was to quantify frequency of abnormal thyroid function post-RI and compare effectiveness common management strategies.