A5002074294- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Diabetic Foot Ulcer Assessment and Management
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Diabetes Treatment and Management
- Diabetes Management and Research
- Wound Healing and Treatments
- Parathyroid Disorders and Treatments
- Glaucoma and retinal disorders
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Pressure Ulcer Prevention and Management
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Education
- Adrenal Hormones and Disorders
- Diet and metabolism studies
- Bone health and osteoporosis research
- Chronic Disease Management Strategies
- Genetic Syndromes and Imprinting
- Retinal and Optic Conditions
- Bone health and treatments
University of Dundee
2014-2024
Ninewells Hospital
2015-2024
NHS Tayside
2008-2024
Chelsea and Westminster Hospital
2024
Genomics (United Kingdom)
2020-2022
National Health Service
2021
Research Network (United States)
2014-2020
NHS Fife
2019
University of Copenhagen
2017
PharmacoGenetics (China)
2017
The nature of the deficit underlying age-related muscle wasting remains controversial. To test whether it could be due to a poor anabolic response dietary amino acids, we measured rates myofibrillar and sarcoplasmic protein synthesis (MPS) in 44 healthy young old men, similar body build, after ingesting different amounts essential acids (EAA). Basal MPS were indistinguishable, but elderly showed less sensitivity responsiveness EAA, possibly decreased intramuscular expression, activation...
<b>Objective</b> To determine whether aspirin and antioxidant therapy, combined or alone, are more effective than placebo in reducing the development of cardiovascular events patients with diabetes mellitus asymptomatic peripheral arterial disease. <b>Design</b> Multicentre, randomised, double blind, 2×2 factorial, controlled trial. <b>Setting</b> 16 hospital centres Scotland, supported by 188 primary care groups. <b>Participants</b> 1276 adults aged 40 type 1 2 an ankle brachial pressure...
OBJECTIVE—To determine the incidence, predisposing factors, and costs of emergency treatment severe hypoglycemia in people with type 1 2 diabetes. RESEARCH DESIGN AND METHODS—Over a 12-month period, routinely collected datasets were analyzed population 367,051 people, including 8,655 diabetes, to measure incidence that required assistance from Ninewells Hospital Medical School (NHS) personnel those primary care, ambulance services, hospital accident departments, inpatient care. Associated...
Type 1 diabetes has historically been associated with a significant reduction in life expectancy. Major advances treatment of type have occurred the past 3 decades. Contemporary estimates effect on expectancy are needed.
Abstract Aims To ascertain the frequency and identify predictors of self‐reported hypoglycaemia in Type 1 insulin‐treated 2 diabetes. Methods A random sample 267 people with diabetes were recruited from a population‐based register Tayside, Scotland. Each subject prospectively recorded number mild severe hypoglycaemic episodes experienced over 1‐month period. Ordinal logistic regression was performed to potential hypoglycaemia. Results Five hundred seventy‐two events reported by 155 patients....
For patients on T(4) replacement, the dose is guided by serum TSH concentrations, but some request higher doses due to adverse symptoms.The aim of study was determine safety having a low not suppressed when receiving long-term replacement.We conducted an observational cohort study, using data linkage from regional datasets between 1993 and 2001.A population-based all in Tayside, Scotland, performed.All taking replacement therapy (n = 17,684) were included.Fatal nonfatal endpoints considered...
Randomized controlled trials have shown the importance of tight glucose control in type 1 diabetes (T1DM), but few recent studies evaluated risk cardiovascular disease (CVD) and all-cause mortality among adults with T1DM. We these risks T1DM compared non-diabetic population a nationwide study from Scotland examined CVD factors those T1DM.The Scottish Care Information-Diabetes Collaboration database was used to identify all people registered aged ≥20 years 2005-2007 provide factor data. Major...
BackgroundFindings from cardiovascular outcome trials suggest that fenofibrate therapy may reduce the progression of diabetic retinopathy.MethodsWe recruited and followed adults with nonreferable retinopathy or maculopathy using national Diabetic Eye Screening (DES) program in Scotland. We randomly assigned participants to receive 145-mg tablets placebo (taken daily or, those impaired renal function, on alternate days). The primary was a composite developing referable (based Scotland's DES...
Glycaemic control in women with diabetes is critical to satisfactory pregnancy outcome. A systematic review of two randomised trials concluded that there was no clear evidence benefit from very tight versus glycaemic for pregnant diabetes.A observational studies addressing miscarriage, congenital malformations and perinatal mortality among type 1 2 carried out. Literature searches were performed MEDLINE, EMBASE, CINAHL Cochrane Library. Observational data on glycated haemoglobin (HbA1c)...
To evaluate prevalence and incidence of diagnosed primary hyperparathyroidism (PHPT) in adults between 1997 2006 Tayside, Scotland, UK.Population-based study.All Tayside residents aged 20 years over with an increased serum calcium level (> 2.55 mmol/l) were included as potential participants. Using a unique patient identifier, data-linkage enabled data set PHPT patients to be created from algorithm biochemistry records, nuclear scan histology hospital clinic letters community based...
A National Screening Programme for diabetic eye disease in the UK is development. We propose a grading and early management protocol to detect sight-threatening retinopathy any retinopathy, which will allow precise quality assurance at all steps while minimizing false-positive referral hospital service.Expert panel structured discussions between 2000 2002 with review of existing evidence classifications.Principles include: separate maculopathy, minimum number steps, compatible central...
To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT).Retrospective population-based observational study.Tayside, Scotland, from 1997 to 2006.Patients PHPT were selected a predefined cohort between 2006.Standardised ratios (SMRs) examined for all-cause mortality, as well cardiovascular cancer mortality. Standardised morbidity standardised incidence also calculated eleven observed co-morbidities.In total, there 1683 (69.1% female)...
The objective of this study was to define the level treated thyroid dysfunction in a complete and representative population base an area sufficient dietary iodine intake. We used record-linkage technology retrospectively identify subjects for hyperthyroidism or hypothyroidism general Tayside, Scotland from 1 January 1993 30 April 1997. Thyroid status ascertained by record linkage patient-level datasets containing details treatments hypothyroidism. identified 620 incident cases...
The aim of the study was to examine association tested TSH with age, gender, and diabetes in a large population-based cohort without evidence thyroid disease.Record-linkage technology used retrospectively identify people disease general population Tayside, Scotland, from July 1, 2003, December 31, 2009.All Tayside residents who had function tests performed were identified. Using unique patient identifier, data linkage enabled be identified by excluding anyone or antithyroid prescription,...
We sought to compare the risk of mortality and hospitalization between patients with without diabetes following incident lower-extremity amputation (LEA).We performed a retrospective data-linkage review all amputations 1 January 1992 31 December 1995. Patients were categorized according their status. Follow-up for was until 2005 March 1996 hospitalization.Of 390 major-incident LEAs during study period, 119 (30.5%) in 271 (69.5%) nondiabetic subjects. The median time death 27.2 months...
Our objective was to investigate the long-term outcomes for patients with endogenous subclinical hyperthyroidism (SH).Population record-linkage technology used retrospectively identify SH and hospital admissions from January 1, 1993, December 31, 2009.All Tayside residents over 18 yr old at least two serum TSH measurements below reference range 4 months apart normal free T(4)/total T(4) total T(3) concentrations baseline were included as potential cases. Using a unique patient identifier,...
OBJECTIVE Metformin is actively transported into the liver by organic cation transporter (OCT)1 (encoded SLC22A1). In 12 normoglycemic individuals, reduced-function variants in SLC22A1 were shown to decrease ability of metformin reduce glucose excursion response oral glucose. We assessed effect two common loss-of-function polymorphisms on a large cohort patients with type 2 diabetes. RESEARCH DESIGN AND METHODS The Diabetes Audit and Research Tayside Scotland (DARTS) database includes...
We aimed to examine time trends in national perinatal outcomes pregnancies complicated by pre-existing type 1 or 2 diabetes. analysed episode-level data on all obstetric inpatient delivery events (live stillbirth) between April 1998 and 31 March 2013 (n = 813,921) using the Scottish Morbidity Record (SMR02). Pregnancies mothers with 3229) 1452) diabetes were identified from database (Scottish Care Information-Diabetes), compared among women diabetes, those without The number of increased...
Summary Objective We aimed to describe the changing incidence of thyroid disease in a population‐based study Tayside, Scotland (population 390 000) between 1994 and 2001. Design A retrospective, data‐linkage, measuring prevalence disease. Patients All patients with newly diagnosed, treated stable Tayside were identified by electronic linkage six datasets, including all regional biochemistry data, hospital admissions, deaths follow‐up register. Results The overall dysfunction has increased...
Sulfonylureas are metabolized mainly by the cytochrome p450 2C9 (CYP2C9) enzyme. Two CYP2C9 variants—*2 (Arg144Cys) and *3 (Ile359Leu)—are associated with reduced enzyme activity impaired substrate metabolism. We identified 1,073 incident users of sulfonylureas in Tayside, Scotland, assessed impact combined CYP2C9*2 CYP2C9*3 genotypes on early sustained sulfonylurea response. found that patients two copies a loss-of-function allele were 3.4 times (P = 0.0009) more likely to achieve treatment...
Current drug labels for thiazolidinediones (TZDs) warn of increased fractures, predominantly distal fractures in women. We examined whether exposure to TZDs affects hip fracture women and men compared the risk that found with other drugs used diabetes.Using a nationwide database prescriptions, hospital admissions deaths those type 2 diabetes Scotland we calculated TZD among 206,672 individuals. Discrete-time failure analysis was model effect cumulative on during 1999-2008.There were 176...