A5009155196- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Genital Health and Disease
- Venous Thromboembolism Diagnosis and Management
- Metabolism, Diabetes, and Cancer
- Healthcare Systems and Technology
- Cancer Risks and Factors
- Intestinal and Peritoneal Adhesions
- Social Media in Health Education
- Cancer and Skin Lesions
- scientometrics and bibliometrics research
- Cancer survivorship and care
- Urologic and reproductive health conditions
- PI3K/AKT/mTOR signaling in cancer
- Pelvic and Acetabular Injuries
- BRCA gene mutations in cancer
Rush University Medical Center
2016-2025
Rush University
2016-2025
Institute for Clinical Pharmacodynamics (United States)
2013
Gynecologic Oncology Group
2012
University of Oklahoma Health Sciences Center
2012
Roswell Park Comprehensive Cancer Center
2012
National Cancer Institute
2012
The University of Texas MD Anderson Cancer Center
2012
University of Minnesota
2012
Nationwide Children's Hospital
2012
The status of p53 in a tumor can be inferred by next-generation sequencing (NGS) or immunohistochemistry (IHC). We examined the association between IHC and sequence whether alone, integrated with TP53 NGS, predicts outcome.From GOG-86P, randomized phase II study chemotherapy combined either bevacizumab temsirolimus advanced endometrial cancer, 213 cases had protein expression data measured NGS data. An analysis was designed to integrate presence absence mutation. These variables were further...
While Caucasian women are more likely to be diagnosed with endometrial cancer compared African-American women, the rate of mortality is higher for African Americans. The cause this disparity unknown. We analyzed time interval from diagnosis treatment as it pertains race and socioeconomic factors its possible impact on survival.This was a retrospective, single institution chart review using registry database. identified 889 patients who were between January 2005 June 2012. Clinicopathologic...
Endometrial cancer (EC) ranks as the most common gynecologic malignancy in USA. While minimally invasive surgical (MIS) techniques have revolutionized EC management, conversion to laparotomy remains a concern due loss of laparoscopic benefits such fewer site infections and shorter hospital stays with reported rates varying widely. Factors influencing this conversion, including patient characteristics tumor attributes, not been fully understood. Our study aims provide framework for...
Abstract Purpose: Effective treatments for advanced endometrial cancer are lacking. Novel therapies that target specific pathways hold promise better treatment outcomes with less toxicity. Mutation activation of the FGFR2/RAS/ERK pathway is important in tumorigenesis. RPS6KA6 (RSK4) a putative tumor suppressor gene and ERK signaling pathway. We explored role RSK4 cancer. Experimental Design: showed expressed normal tissue absent or much reduced On basis previous reports on methylation other...
To evaluate the utility of liquid-based cytology in detecting recurrent cervical cancer among treated patients.A retrospective multi-institution study identified patients for from January 1, 2000, to November 2009, through local registries and patient databases. Patients were excluded if they lacked follow-up or treatment data.In all, 4,167 results 929 women identified. Of these, 626 (15%) Pap test 312 (34%) abnormal, including 296 atypical squamous cells undetermined significance (ASC-US;...
Serous uterine cancer is not a feature of any known hereditary syndrome. This study evaluated familial risk cancers for patients with serous carcinoma, focusing on Lynch syndrome malignancies. Fifty or mixed endometrial carcinoma cases were prospectively enrolled. Pedigrees developed 29 probands and tumors assessed DNA mismatch repair (MMR) abnormalities. Standardized incidence ratios in relatives estimated. A second-stage analysis was undertaken using data from Gynecologic Oncology Group...
Squamous differentiation (SD) and morular metaplasia (MM) are frequently present in uterine endometrioid adenocarcinoma (EAC) can mimic areas of solid tumor. We used immunohistochemical stains to further characterize these lesions, determine which markers would help distinguish metaplasias from growth EAC. The pathology database was searched for diagnoses EAC 1997 2007, the hematoxylin eosin-stained slides were reviewed, 143 cases with SD, MM, or both (SD+MM) identified. A panel performed....
In Brief OBJECTIVE: To describe the characteristics of women who experience chronic fissuring posterior fourchette and outcome treatment administered. METHODS: We conducted a retrospective review 42 with granuloma fissuratum presenting for care between January 1, 1995, December 31, 2003. Women underwent medical management first, if improvement was minimal, perineoplasty recommended. Dyspareunia vulvar symptom scores, including itching, burning, pain, before after were compared. RESULTS:...
In Brief BACKGROUND: Uterine artery embolization is a common procedure for symptomatic leiomyomas and being used as less invasive alternative to hysterectomy. This report of an uteroenteric fistula after uterine embolization. CASE: A 50-year-old woman developed that was seen on computed tomography scan 6 months she had uncomplicated leiomyomas. She managed surgically with hysterectomy small bowel resection reanastomosis. CONCLUSION: Uteroenteric can occur complication leiomyoma management. form
• NACT use among SGO members for ovarian cancer is explored given recent trials. Fewer feel they can't predict optimal cytoreduction pre-operatively. Laparoscopy has increased both diagnosis and treatment of cancer. Very high rates are reported from members. Despite studies, don't regularly treat patients with NACT/ID.