A5055457903- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Reproductive tract infections research
- Gut microbiota and health
- Pelvic floor disorders treatments
- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Lymphoma Diagnosis and Treatment
- Gestational Trophoblastic Disease Studies
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Neutropenia and Cancer Infections
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Ureteral procedures and complications
- Cancer Mechanisms and Therapy
- Cancer Diagnosis and Treatment
University of Miami
2014-2023
Sylvester Comprehensive Cancer Center
2013-2023
Jackson Memorial Hospital
2006-2022
University of Canterbury
2003-2008
Royal Bolton Hospital
2001
The Christie Hospital
1994
Cancer Research UK
1991
The human microbiome has been strongly correlated with disease pathology and outcomes, yet remains relatively underexplored in patients malignant endometrial disease. In this study, vaginal samples were prospectively collected at the time of hysterectomy from 61 racially ethnically diverse three conditions: 1) benign gynecologic (controls, n=11), 2) low-grade carcinoma (n=30), 3) high-grade (n=20). Extracted DNA underwent shotgun metagenomics sequencing, microbial α β diversities calculated....
Damage to apoB100 on low density lipoprotein (LDL) has usually been described in terms of lipid aldehyde derivatisation or fragmentation. Using a modified FOX assay, protein hydroperoxides were found form at relatively high concentrations during copper, 2,2′-azobis(amidinopropane) dihydrochloride (AAPH) generated peroxyl radical and cell-mediated LDL oxidation. Protein hydroperoxide formation was tightly coupled oxidation both copper AAPH-mediated The inhibited by soluble α-tocopherol the...
Recurrent metastatic choriocarcinoma is a rare disease with historically limited guidance in the literature regarding standardized treatment protocols. In this case report, we review course of patient recurrent re-treated single agent pembrolizumab.Our was initially diagnosed (FIGO Stage IV, WHO Score 13) after presenting for evaluation amenorrhea. She received standard etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine (EMA-CO), complete response. However, she recurred...
Background Nelfinavir (NFV), an HIV‐1 protease inhibitor, has been shown to sensitize cancer cells chemoradiation (CRT). The objectives of this phase 1 trial were evaluate safety and identify the recommended 2 dose NFV added concurrent CRT for locally advanced cervical cancer. Methods Two levels evaluated: 875 mg orally twice daily (dose level [DL1]) 1250 (DL2). was initiated 7 days before continued through completion. Toxicity, radiographic responses, pathologic responses evaluated. Serial...
Myoepithelial carcinoma and proximal-type epithelioid sarcoma of the vulva are two rare malignancies with known aggressive behavior. In addition to a similar clinical course, these disease entities also have significant histologic pathologic overlap. Given rarity malignancies, there is limited literature on appropriate treatment regimen. Nevertheless, consensus that early surgical resection beneficial in both cases. We present case patient who was initially diagnosed myoepithelial...
TPS5619 Background: Despite platinum based chemoradiation (C-XRT), 40-50% of women with locally advanced cervical cancer will die from their disease. Nelfinavir (NFV), a protease inhibitor, has been shown to target the Akt pathway sensitizing cells chemoradiation. The objective this Phase I trial was determine dose-limiting toxicities (DLT) and genomic proteomic effects NFV in combination standard concurrent C-XRT advance cancer. Methods: After obtaining IRB approval, previously untreated...
Abstract We present a rare case pulmonary metastasis of an early stage endometrial cancer nearly 20 years after curative surgical resection. Our patient had remote history hysterectomy for in 1998 and later Stage 1B right upper lobe lung treated with lobectomy adjuvant chemotherapy 2014. She was found to have enlarging nodule the left 2018, which thought be another primary cancer. underwent segmentectomy intraoperative diagnosis adenocarcinoma by diagnostic wedge resection nodule. Final...