A5014922905- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Cancer-related molecular mechanisms research
- Preterm Birth and Chorioamnionitis
- Neuroscience and Neuropharmacology Research
- Hemoglobinopathies and Related Disorders
- RNA Research and Splicing
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Fetal and Pediatric Neurological Disorders
- Epilepsy research and treatment
- RNA modifications and cancer
- Neuroscience of respiration and sleep
- Pharmacological Effects and Toxicity Studies
University of Alabama at Birmingham
2021-2024
Johns Hopkins Medicine
2013-2017
Johns Hopkins University
2013-2017
Preterm birth is a major risk factor for adverse neurological outcomes in ex-preterm children, including motor, cognitive, and behavioral disabilities. N-acetyl-L-cysteine therapy has been used clinical studies; however, it requires doses that cause significant side effects. In this study, we explore the effect of low dose therapy, delivered using targeted, systemic, maternal, dendrimer nanoparticle (DNAC), mouse model intrauterine inflammation. Our results demonstrated intraperitoneal...
Temporal lobe epilepsy (TLE) is a type of focal characterized by spontaneous recurrent seizures originating from the hippocampus. The epigenetic reprogramming hypothesis epileptogenesis suggests that development TLE associated with alterations in gene transcription changes resulting hyperexcitable network TLE. DNA 5-methylcytosine (5-mC) an mechanism has been chronic epilepsy. However, contribution 5-hydroxymethylcytosine (5-hmC), product 5-mC demethylation Ten-Eleven Translocation (TET)...
Abstract Dysregulation of long non-coding RNAs (lncRNAs) have been associated with Alzheimer’s disease (AD). However, the functional role lncRNAs in AD remains unclear. Here, we report a crucial for lncRNA Neat1 astrocyte dysfunction and memory deficits AD. Transcriptomics analysis show abnormally high expression levels NEAT1 brains patients relative to aged-matched healthy controls, most significantly elevated glial cells. In human transgenic APP-J20 (J20) mouse model AD, RNA-fluorescent...
The therapeutic potential of aerobic exercise in mitigating seizures and cognitive issues temporal lobe epilepsy (TLE) is recognized, yet the underlying mechanisms are not well understood. Using a rodent TLE model induced by Kainic acid (KA), we investigated impact single bout (i.e., acute) or 4 weeks chronic). Blood was processed for epilepsy-associated serum markers, DNA methylation (DNAme), hippocampal area CA3 assessed gene expression levels DNAme-associated enzymes. While acute did...
Investigating the contribution of long non-coding RNA (lncRNA) Neat1 to memory deficits associated with normal aging and Alzheimer's disease (AD).
Temporal lobe epilepsy (TLE) is a type of focal characterized by spontaneous recurrent seizures originating from the hippocampus. The epigenetic reprogramming hypothesis epileptogenesis suggests that development TLE associated with alterations in gene transcription changes resulting hyperexcitable network TLE. DNA 5-methylcytosine (5-mC) an mechanism has been chronic epilepsy. However, contribution 5-hydroxymethylcytosine (5-hmC), product 5-mC demethylation Ten-Eleven Translocation (TET)...
BACKGROUND: There are no definitive markers to aid in diagnosis of neonatal encephalopathy (NE). The purpose our study was: 1) identify and evaluate the utility neuronal nitric oxide synthase (NOS1) umbilical cord blood as a NE biomarker; 2) source NOS1 blood. METHODS: This was nested case-control neonates >35 weeks gestation. ELISA for performed. Sources were investigated by immunohistochemistry, western blot, quantitative PCR. Furthermore, cords full term subjected 1% hypoxia ex vivo....