A5053650661- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Essential Oils and Antimicrobial Activity
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Ethnobotanical and Medicinal Plants Studies
- African Botany and Ecology Studies
- Genomics and Chromatin Dynamics
- Nanoparticle-Based Drug Delivery
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Epilepsy research and treatment
- Histone Deacetylase Inhibitors Research
- Bone Tissue Engineering Materials
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- Advanced biosensing and bioanalysis techniques
- Piperaceae Chemical and Biological Studies
- Seed and Plant Biochemistry
- Advanced Chemical Sensor Technologies
- Phytochemistry and Biological Activities
- Biochemical effects in animals
University of Alabama at Birmingham
2017-2024
HudsonAlpha Institute for Biotechnology
2023-2024
University of Alabama in Huntsville
2014
Memory retrieval induces a transient period of increased transcriptional and translational regulation in neurons called reconsolidation, which is regulated by the protein kinase B (AKT)-mammalian target rapamycin (mTOR) pathway. However, it currently unknown how activation AKT-mTOR pathway during reconsolidation process. Here, we found that male rats contextual fear memory transiently Enhancer Zeste Homolog 2 (EZH2) levels along with histone H3 lysine 27 trimethylation (H3K27me3) levels,...
Temporal lobe epilepsy (TLE) is a type of focal characterized by spontaneous recurrent seizures originating from the hippocampus. The epigenetic reprogramming hypothesis epileptogenesis suggests that development TLE associated with alterations in gene transcription changes resulting hyperexcitable network TLE. DNA 5-methylcytosine (5-mC) an mechanism has been chronic epilepsy. However, contribution 5-hydroxymethylcytosine (5-hmC), product 5-mC demethylation Ten-Eleven Translocation (TET)...
ABSTRACT Background Tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates tau, microtubule associated protein encoded the MAPT gene. expression is absent in neural progenitor cells (NPCs) and increases during differentiation. This temporally dynamic pattern suggests that controlled transcription factors cis-regulatory elements specific to differentiated cell types. Given relevance neurodegeneration pathogenesis, identification such relevant understanding genetic...
The leaf essential oil of Parquetina nigrescens collected from Badary, Nigeria, was obtained by hydrodistillation and analyzed gas chromatography - mass spectrometry. had a simple composition with only five identified components. dominated citral (35.0% neral 53.7% geranial). high concentration in the likely contributes to ethnomedicinal utility bioactivities associated this medicinal plant.
Ultrasmall iron oxide nanoparticles (USIONPs) have been recently developed as labeling probes for T2 magnetic resonance imaging contrast agents. However, their use in stem cell tracking has limited, especially T1 In this study, we studied the effects of USIONP surface coatings on proliferation, cellular uptake, and multipontency established primary neural cells (NSCs). USIONPs were functionalized with gluconic acid (GA), tannic (TA), hyaluronic (HA) to label NSCs. All characterized agents...
Temporal lobe epilepsy (TLE) is a type of focal characterized by spontaneous recurrent seizures originating from the hippocampus. The epigenetic reprogramming hypothesis epileptogenesis suggests that development TLE associated with alterations in gene transcription changes resulting hyperexcitable network TLE. DNA 5-methylcytosine (5-mC) an mechanism has been chronic epilepsy. However, contribution 5-hydroxymethylcytosine (5-hmC), product 5-mC demethylation Ten-Eleven Translocation (TET)...
Abstract Background Tau is encoded by MAPT and abnormal aggregates of tau are a hallmark many neurodegenerative diseases. highly expressed in neurons but much more lowly other cell types, including neural precursor cells (NPCs), suggesting that its expression may be controlled neuron‐specific transcription factors cis‐regulatory elements. reduction, even endogenous tau, current therapeutic strategy both model systems humans; therefore, understanding regulation point to new strategies achieve...