A5100745301- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Obesity, Physical Activity, Diet
- Heavy Metal Exposure and Toxicity
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Maternal Mental Health During Pregnancy and Postpartum
- Prenatal Substance Exposure Effects
- Folate and B Vitamins Research
- Child Nutrition and Feeding Issues
- Health, Environment, Cognitive Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Autism Spectrum Disorder Research
- Child Nutrition and Water Access
- Cardiovascular Health and Risk Factors
- Diet and metabolism studies
- Attention Deficit Hyperactivity Disorder
- Pregnancy and Medication Impact
- Regulation of Appetite and Obesity
- Growth Hormone and Insulin-like Growth Factors
Xian Yang Central Hospital
2023-2025
The Fourth People's Hospital
2024-2025
Johns Hopkins University
2015-2024
Peking University
2002-2024
Bloomberg (United States)
2019-2024
Wenzhou Medical University
2023
Dongyang People's Hospital
2023
Johns Hopkins Medicine
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2022
Qilu Hospital of Shandong University
2022
BACKGROUND: Obesity and diabetes are highly prevalent among pregnant women in the United States. No study has examined independent combined effects of maternal prepregnancy obesity on risk autism spectrum disorder (ASD) parallel with other developmental disorders (DDs). METHODS: This is based 2734 children (including 102 ASD cases), a subset Boston Birth Cohort who completed at least 1 postnatal visit Medical Center between 1998 2014. Child DDs were physician diagnoses as documented...
To examine the prospective association between multivitamin supplementation during pregnancy and biomarker measures of maternal plasma folate vitamin B12 levels at birth child's Autism Spectrum Disorder (ASD) risk.This report included 1257 mother-child pairs, who were recruited prospectively followed through childhood Boston Medical Center. ASD was defined from diagnostic codes in electronic medical records. Maternal assessed via questionnaire interview; measured samples taken 2-3 days after...
<h3>Importance</h3> Although previous reports have linked preterm birth with insulin resistance in children and adults, it is not known whether altered homeostasis detectable at tracks from through childhood. <h3>Objective</h3> To investigate associated elevated plasma levels this association persists into early <h3>Design, Setting, Participants</h3> A prospective cohort of 1358 recruited 1998 to 2010 followed-up prospectively 2005 2012 the Boston Medical Center Massachusetts. <h3>Main...
The opioid epidemic increasingly affects pregnant women and developing fetuses, resulting in high rates of neonatal abstinence syndrome. However, longitudinal studies that prospectively observe newborns with syndrome or maternal use examine their long-term physical neurodevelopmental outcomes are lacking.To prenatal risk factors associated during pregnancy the short-term health consequences on children.This cohort study analyzed data from Boston Birth Cohort, an urban, low-income,...
Prior studies have raised concern about maternal acetaminophen use during pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) autism spectrum (ASD) in their children; however, most relied on self-report.To examine the prospective associations between cord plasma metabolites physician-diagnosed ADHD, ASD, both ADHD developmental disabilities (DDs) childhood.This cohort study analyzed 996 mother-infant dyads, a subset Boston Birth Cohort, who were enrolled at birth...
<h3>Importance</h3> Previous reports have linked maternal prepregnancy obesity with low folate concentrations and child overweight or (OWO) in separate studies. To our knowledge, the role of concentrations, alone combination OWO, metabolic health has not been examined a prospective birth cohort. <h3>Objective</h3> test hypotheses that can significantly affect sufficient mitigate obesity-induced risk. <h3>Design, Setting, Participants</h3> This cohort study was conducted at Boston Medical...
Abstract This study aimed to investigate the optimal degree of weight gain across gestational spectrum in 1971 children enrolled at birth and followed up age 7 years. Weight infancy was categorized into four groups based on z -scores: slow (<−0.67), track (−0.67 0.67), rapid (0.67 1.28), extremely (>1.28). Underweight overweight or obesity (OWO) were defined as a body mass index ≤5 th ≥85 percentile, respectively, for gender. In our population, OWO far more common than underweight...
Background Preeclampsia is a leading contributor to maternal and perinatal morbidity mortality. In mice experiments, manganese (Mn) selenium (Se) are protective whereas cadmium (Cd) promotive for preeclampsia. Epidemiologic findings on these chemical elements have been inconsistent. To confirm experimental in mice, we examined associations of trace minerals (Mn Se) heavy metals (Cd, lead [Pb], mercury [Hg]) with preeclampsia birth cohort. Methods Results A total 1274 women from the Boston...
Abstract Background Maternal smoking affects more than half a million pregnancies each year in the US and is known to result fetal growth restriction as measured by lower birthweight its associated long-term consequences. also has been linked altered DNA methylation (DNAm). However, what remains largely unexplored whether these DNAm alterations are merely markers of exposure or if they have implications for health outcomes. This study tested hypothesis that mediates effect maternal on...
In utero exposure to heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) may be associated with higher childhood blood pressure (BP), whereas trace elements selenium (Se) manganese (Mn) have protective antioxidant effects that modify metal-BP associations. We examined the individual joint of in Pb, Hg, Cd, Se, Mn on BP. used data from Boston Birth Cohort (enrolled 2002-2013). measured maternal red cells collected 24-72 h after delivery. calculated child BP percentile per 2017 American...
Mitochondria are essential for brain development. While previous studies linked dysfunctional mitochondria with autism spectrum disorder (ASD), the role of mitochondrial genome (mtDNA) in ASD risk is largely unexplored. This study investigates association mtDNA heteroplasmies (co-existence mutated and unmutated mtDNA) content ASD, as well its inter-generational transmission sex differences among two independent samples: a family-based (n = 1,938 families parents, probands sibling controls)...
Background Preeclampsia is a major cause of maternal and fetal morbidity mortality. Given its large public health burden, there need to identify modifiable factors that can be targeted for preeclampsia prevention. In this study, we examined whether Mediterranean‐style diet protective in cohort racially ethnically diverse, urban, low‐income women. Methods Results We used data from the Boston Birth Cohort. Maternal sociodemographic dietary were obtained via interview food frequency...
We examined whether the risk of food-allergen sensitization varied according to self-identified race or genetic ancestry.We studied 1104 children (mean age: 2.7 years) from an urban multiethnic birth cohort. Food was defined as specific immunoglobulin E (sIgE) levels ≥ 0.35 kilo-units allergen (kUA)/L for any 8 common food allergens. Multivariate logistic regression analyses were used evaluate associations and ancestry with sensitization. Analyses also numbers sensitizations (0, 1 2, 3...
To evaluate the association between prepregnancy body mass index (BMI) is associated with early vs. late and medically-induced spontaneous preterm birth (PTB) subtypes. Using data from Boston Birth Cohort, we examined associations of BMI 189 (<34 completed weeks) 277 (34–36 PTBs 320 610 3281 term births (37–44 in multinomial regression. assess for mediation by important pregnancy complications, performed sequential models without hypertensive disorders pregnancy, chorioamnionitis,...
<h3>Importance</h3> The first pediatric lead screening typically occurs at 1-year well-child care visits. However, data on the extent of maternal exposure and its long-term consequences for child health are lacking. <h3>Objective</h3> To investigate associations between red blood cell (RBC) levels intergenerational risk overweight or obesity (OWO) whether adequate folate status is associated with a reduction in OWO risk. <h3>Design, Setting, Participants</h3> Prospective birth cohort study....
<h3>Importance</h3> Polysubstance use among pregnant women has increased because of the opioid epidemic and increasing legalization cannabis along with persistent tobacco alcohol consumption. Previous research on prenatal substance child’s risk attention-deficit/hyperactivity disorder (ADHD) mostly focused single-substance exposures; simultaneous examination multiple assessment their synergistic health consequences is needed. <h3>Objectives</h3> To assess specific substances during...