Systemic inflammation is a potent contributor to increased seizure susceptibility. However, information regarding the effects of systemic on cerebral vascular integrity that influence neuron excitability scarce. Necroptosis closely associated with in various neurological diseases. In this study, necroptosis was hypothesized be involved mechanism underlying sepsis-associated neuronal cerebrovascular components (e.g., endothelia cells).Lipopolysaccharide (LPS) used induce inflammation. Kainic...

Abstract Background Maternal smoking affects more than half a million pregnancies each year in the US and is known to result fetal growth restriction as measured by lower birthweight its associated long-term consequences. also has been linked altered DNA methylation (DNAm). However, what remains largely unexplored whether these DNAm alterations are merely markers of exposure or if they have implications for health outcomes. This study tested hypothesis that mediates effect maternal on...

Background Despite Taiwan’s advanced healthcare system, many women delay seeking medical attention for breast abnormalities, leading to worsened health outcomes and increased costs. Objective To explore the psychological journeys of patients with cancer who delayed consultation presented large tumors. Methods A phenomenological qualitative study was conducted using purposive sampling semistructured interviews 12 participants. Giorgi’s method guided data analysis. Results Most participants...

The specific properties of gold nanoparticles (AuNPs) make them a novel class photothermal agents that can induce cancer cell damage and even death through the conversion optical energy to thermal energy. Most relevant studies have focused on increasing precision targeting, improving efficacy transfer, exploring additional functions. Nevertheless, most cells uptake nanosized particles nonspecific endocytosis; therefore, before hyperthermia via AuNPs be applied for clinical use, it is...

Maternal pre-pregnancy obesity is an established risk factor for childhood obesity. Investigating epigenetic alterations induced by maternal during fetal development could gain mechanistic insight into the developmental origins of While disproportionately affects underrepresented racial and ethnic mothers children in USA, few studies investigated role prenatal programming intergenerational these high-risk populations.This study included 903 mother-child pairs from Boston Birth Cohort, a...

Introduction Hot flashes have been postulated to be linked systemic inflammation. This study aimed investigate the relationship between hot flashes, pro-inflammatory factors, and leukocytes in healthy, non-obese postmenopausal women. Participants design In this cross-sectional study, a total of 202 women aged 45–60 years were stratified into one four groups according their hot-flash status: never experienced (Group N), mild m), moderate M), severe S). Variables measured included clinical...

Introduction Hot flashes have been postulated to be linked the development of metabolic disorders. This study aimed evaluate relationship between hot flashes, adipocyte-derived hormones, and insulin resistance in healthy, non-obese postmenopausal women. Participants design In this cross-sectional study, a total 151 women aged 45–60 years were stratified into one three groups according hot-flash status over past months: never experienced (Group N), mild-to-moderate M), severe S). Variables...

BackgroundDNA methylation (DNAm) in cord blood has been associated with various prenatal factors and birth outcomes. This study sought to fill an important knowledge gap: the link of DNAm child postnatal growth trajectories from age 18 years (y).MethodsUsing data a US predominantly urban, low-income, multi-ethnic cohort (N = 831), we first applied non-parametric methods identify body-mass-index percentile (BMIPCT) y (the outcome); then, conducted epigenome-wide association (EWAS) outcome,...

Sleep disturbance is very common in menopausal women and poor sleep quality has been linked to systemic inflammation. However, the impact of on health outcomes remains unclear. This study evaluated relationships between inflammation women.This cross-sectional enrolled 281 healthy aged 45 60 years. The Pittsburgh Quality Index (PSQI) was used measure sleep. Multiplex assays were levels 9 cytokines morning fasting plasma samples. Other variables measured this included clinical characteristics...

Overweight or obesity (OWO) in school-age childhood tends to persist into adulthood. This study aims address a critical need for early identification of children at high risk developing OWO by defining and analyzing longitudinal trajectories body mass index percentile (BMIPCT) during developmental windows.We included 3029 from the Boston Birth Cohort (BBC) with repeated BMI measurements birth age 18 years. We applied locally weighted scatterplot smoothing time-limit scheme predefined rules...

L-Arginine transport mediated by type 2 cationic amino acid transporter (CAT-2) is one crucial mechanism that regulates nitric oxide production inducible synthase. Heme oxygenase (HO)-1 induction has been reported to significantly attenuate synthase expression and production. The authors sought explore the effects of HO-1 on CAT-2 L-arginine transport. nuclear factor E2-related (Nrf2) kappaB (NF-kappaB) were also investigated.Murine macrophages (RAW264.7 cells) randomized receive...

With the popularity of internet, short videos have become an indispensable tool to obtain health information. However, avoiding disinformation owing openness Internet is difficult for users. Disinformation may endanger and lives

Introduction Studies on the association between adiponectin and leptin anxiety depression among postmenopausal women are limited. Therefore, present study specifically evaluates mutual relationships in women. Participants design In this cross-sectional study, a total of 190 aged 40–65 years were enrolled. Depression symptoms assessed using Center for Epidemiologic Scale (CES-D), evaluated Hamilton Anxiety Rating (HAM-A). Fasting specimens collected to measure sex hormone, glucose, insulin,...

Implementation researchers have sought ways to use simulations support the core components of implementation, which typically include assessing need for change, designing implementation strategies, executing and evaluating outcomes. The goal this paper is explain how agent-based modeling could fulfill role.We describe with respect other simulation methods that been used in science, using non-technical language broadly accessible. We then provide a stepwise procedure developing models...

The electricity market in the U.S. is changing rapidly from a utility-scale centralized generation-distribution model to more distributed and customer-sited energy model. Increasingly, residential consumers are showing interest solar-based electricity, which has resulted increased adoption of solar on rooftops owner-occupied residences. However, limited accessibility rooftop photovoltaic (PV) led equity concerns among policymakers. Also, utility companies face decline revenues as residents...

Beyond fertility, follicle-stimulating hormone (FSH) may exert action on adipocytes, which are the major source of adiponectin and leptin, linking to insulin resistance. Therefore, we evaluated relationships between FSH adipocyte-derived hormones. This cross-sectional study enrolled postmenopausal women aged 40–65 years. The variables measured in this included clinical parameters, fasting levels sex hormones, glucose, insulin, adipokines. A total 261 without breast cancer, 88 with cancer...

Energy conservation in residential buildings has been a topic of interest recent years because their high levels energy consumption. Weatherization is set approaches that can be used to make more energy-efficient, thereby helping residents lower bills and improving environmental sustainability. However, there are two significant challenges associated with weatherization adoption: upfront investment costs long payback period, minimal awareness its benefits. This paper proposes an agent-based...

Optimizing the allocation of university resources to improve efficiency inputs and outputs is an important issue for high-quality development universities. In recent years, China has become growth pole global higher education. particular, Chinese agricultural universities, with their distinctive disciplinary characteristics outstanding professional advantages, have made contributions sustainable education around world. contrast, academic research on resource in universities very limited. To...

This work surveyed residents of an economically disadvantaged community on their attitudes toward weatherization and energy use behaviors. To support urban leaders making decisions to mitigate the effects large-scale climate change, data-driven simulation models are being developed. ensure that these equitable, needs all citizens must be included, especially those most vulnerable impacts change. The results this survey indicate taking steps weatherize conserve energy, but they hindered by a...

Objective: The research aims to investigate whether β2-adrenergic receptor agonists could attenuate hippocampal cognitive deficits of the mice following sepsis. Background: Systemic inflammation leads a number mediated physiological changes in central nervous system. In previous studies, it has demonstrated that peripheral may induce microglia activation, leading neuronal dysfunction and progressive defects. Our study showed β2 adrenergic have an anti-inflammatory effect on innate immune....

Background and Objective Accumulated evidence suggests that systemic inflammation leads to increased neuronal excitability dominantly arising from microglia activation in CNS. The underlying mechanisms the signaling pathways involved these phenomena remain yet well understood. NADPH oxidase complexes (Nox2) generating superoxide anion (O2-) is essential for activation. We hypothesized Nox2-derived ROS has a major impact on seizure susceptibility after sepsis. Methods investigated role of...