A5011037328- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal disorders and treatments
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Urologic and reproductive health conditions
- Soft tissue tumor case studies
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- AI in cancer detection
- Chronic Myeloid Leukemia Treatments
- Medical Imaging and Pathology Studies
- Platelet Disorders and Treatments
- Renal and related cancers
- Colorectal Cancer Surgical Treatments
The University of Texas Health Science Center at Houston
2007-2025
Seoul National University Hospital
2023
The University of Texas MD Anderson Cancer Center
2012-2022
King Chulalongkorn Memorial Hospital
2014
Huntsman Cancer Institute
2007
University of Utah
2007
University of San Diego
2007
Baylor College of Medicine
1997-2006
University of Houston
1996
Response Evaluation Criteria in Solid Tumors (RECIST) are insensitive evaluating gastrointestinal stromal tumors (GISTs) treated with imatinib. This study evaluates whether computed tomography (CT) findings of GIST after imatinib treatment correlate tumor responses by [18F]fluorodeoxyglucose (FDG) positron emission (PET) and develops reliable, quantitative, CT response criteria.A total 172 lesions selected RECIST were evaluated 40 patients metastatic GISTs All had pretreatment 2-month...
The NCCN Soft Tissue Sarcoma Guidelines include a subsection about treatment recommendations for gastrointestinal stromal tumors (GISTs). standard of practice rapidly changed after the introduction effective molecularly targeted therapy (such as imatinib and sunitinib) GIST. Because these changes, organized multidisciplinary panel composed experts in fields medical oncology, molecular diagnostics, pathology, radiation surgery to discuss optimal approach care patients with GIST at all stages...
Response Evaluation Criteria in Solid Tumors (RECIST) are insensitive evaluating imatinib-treated gastrointestinal stromal tumors (GISTs). by Choi criteria, a 10% decrease size or 15% density on contrast-enhanced CT, correlated well small training set of patients who showed response as measured positron emission tomography, and was more predictive time to tumor progression (TTP) than RECIST. This study designed validate these observations an independent data set.Fifty-eight with GISTs were...
OBJECTIVE. We correlated changes in tumor density on CT with glucose metabolism, or the maximum standardized uptake value (SUVmax), FDG PET and sought to develop imaging criteria that can be used objectively evaluate response patients metastatic gastrointestinal stromal tumors (GISTs) who undergo treatment imatinib mesylate.
In Brief Background: Radiofrequency ablation (RFA) has become a common treatment of patients with unresectable primary and secondary hepatic malignancies. We performed this prospective analysis to determine early (within 30 days) late (more than days after) complication rates associated tumor RFA. Methods: All treated between January 1, 1996 June 30, 2002 RFA for malignancies were entered into database. Patients evaluated during treatment, throughout the immediate post course, then every 3...
Abstract BACKGROUND: Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS: We retrospectively analyzed the records of 14 patients histopathologically confirmed who were treated at The University Texas MD Anderson Cancer Center between May 2005 June 2007. All temozolomide 150...
Abstract KIT gain of function mutations play an important role in the pathogenesis gastrointestinal stromal tumors (GISTs). Imatinib is a selective tyrosine kinase inhibitor ABL, platelet-derived growth factor receptor (PDGFR), and represents new paradigm targeted therapy against GISTs. Here we report for first time that, after imatinib treatment, additional specific novel mutation occurs GISTs as they develop resistance to drug. We studied 12 GIST patients with initial near-complete...
Detection of Small Pancreatic Tumors with Multiphasic Helical CTYulia Lisenko Bronstein1, Evelyne M. Loyer2, Harmeet Kaur2, Haesun Choi2, Cynthia David2, Ronelle A. DuBrow2, Lyle D. Broemeling3, Karen R. Cleary4 and Chusilp Charnsangavej2Audio Available | Share
Gastrointestinal stromal tumor (GIST) is the most common sarcoma arising in gastrointestinal (GI) tract. Imatinib mesylate (imatinib) efficacious treating advanced and metastatic GIST. Patients undergoing resection of GIST realize a highly variable median disease-free survival (DFS). In absence prospective data, we conducted randomized, phase II study to assess safety efficacy preoperative postoperative imatinib for treatment Nineteen patients surgical were randomized receive 3, 5, or 7 days...
Purpose: For nonsmall cell lung cancer (NSCLC) patients, quantitative image features extracted from computed tomography (CT) images can be used to improve tumor diagnosis, staging, and response assessment. these findings clinically applied, need have high intra intermachine reproducibility. The objective of this study is identify CT that are reproducible, nonredundant, informative across multiple machines. Methods: Noncontrast‐enhanced, test‐retest pairs were obtained 56 NSCLC patients...
An alternative to surgical resection of liver tumors, radio-frequency ablation induces in situ thermal coagulation necrosis through the delivery high-frequency alternating current tissues. Imaging helps detect treatable lesions, guide placement probe, and assess effect therapy. Computed tomography (CT) is used most frequently determine whether complete screen for early recurrences that may benefit from reablation. Complete creates an area that, at CT, low attenuation compared with...
Endometrial and cervical cancer are the most common gynecologic malignancies in world. Accurate staging of endometrial is essential to determine correct treatment approach. The current International Federation Gynecology Obstetrics (FIGO) system does not include modern imaging modalities. However, magnetic resonance (MR) has proved be accurate noninvasive modality for carcinomas often helps with risk stratification making decisions. Multiparametric MR increasingly being used evaluate female...
Soft-tissue sarcoma: MR imaging vs sonography for detection of local recurrence after surgery.H Choi, D G Varma, B Fornage, E Kim and A JohnstonAudio Available | Share
To report the efficacy, physician-reported toxicity, and patient-reported outcomes of men with intermediate-risk prostate cancer after brachytherapy in a prospective phase 2 trial.This trial involved 300 patients previously untreated treated from 2006 through 2013. Eligible had ≤cT2b (T3 excluded according to magnetic resonance imaging), Gleason score (GS) 6 prostate-specific antigen (PSA) level 10-15 ng/mL, or GS 7 PSA <10 were (without hormonal therapy).Median patient age was 64.9 years;...
Background: Subarachnoid Hemorrhage (SAH) accounts for 2-7% of strokes and has high mortality morbidity. We sought to identify peripheral blood transcriptome changes in the acute SAH phase that associated with 90-day outcome, as measured by modified Rankin Scale (mRS), gain insights about potential mechanisms contributing long term outcome. Methods: sequenced patients within 3 days post ictus stratified into Good (mRS≤2, n=37) Poor (mRS≥3, n=23) outcomes at follow up. generated co-expression...
Neutrophils are reported to be critical mediators of poor outcome after subarachnoid hemorrhage (SAH). Following SAH, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs) and NETs have been identified as a therapeutic target prevent delayed cerebral ischemia in mice (DCI) with SAH. In this study, our hypothesis was that markers higher aneurysmal SAH patients developing DCI compared not DCI. Moreover, we hypothesized occlude blood vessels the brain Using patient...