A5103182620- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Topic Modeling
- Radiation Therapy and Dosimetry
- Natural Language Processing Techniques
- Multimodal Machine Learning Applications
- Speech and dialogue systems
- Domain Adaptation and Few-Shot Learning
- Speech Recognition and Synthesis
- Statistical Methods in Clinical Trials
- Advanced Text Analysis Techniques
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Explainable Artificial Intelligence (XAI)
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Information Retrieval and Search Behavior
- Testicular diseases and treatments
- Economic and Financial Impacts of Cancer
The University of Texas MD Anderson Cancer Center
2016-2025
Yonsei University
2018-2023
Seoul National University
2021-2023
Microsoft Research Asia (China)
2022
The University of Texas Health Science Center at Houston
2021
University of Edinburgh
2020
Johns Hopkins University
2018
Varian Medical Systems (Germany)
2018
Novartis (China)
2018
Radiation Oncology Associates
2012-2016
Hypofractionated radiotherapy delivers larger daily doses of radiation and may increase the biologically effective dose delivered to prostate. We conducted a randomized trial testing hypothesis that dose-escalated, moderately hypofractionated intensity-modulated therapy (HIMRT) improves prostate cancer control compared with conventionally fractionated IMRT (CIMRT) for men localized cancer.
Purpose To compare the toxicities and cost of proton radiation stereotactic body radiotherapy (SBRT) with intensity-modulated (IMRT) for prostate cancer among men younger than 65 years age private insurance. Methods Using MarketScan Commercial Claims Encounters database, we identified who received between 2008 2015. Patients undergoing therapy SBRT were propensity score–matched to IMRT patients on basis clinical sociodemographic factors. Proportional hazards models compared cumulative...
Despite the super-human accuracy of recent deep models in NLP tasks, their robustness is reportedly limited due to reliance on spurious patterns. We thus aim leverage contrastive learning and counterfactual augmentation for robustness. For augmentation, existing work either requires humans add counterfactuals dataset or machines automatically matches near-counterfactuals already dataset. Unlike affected by correlations, ours, synthesizing “a set” counterfactuals, making a collective decision...
To report the efficacy, physician-reported toxicity, and patient-reported outcomes of men with intermediate-risk prostate cancer after brachytherapy in a prospective phase 2 trial.This trial involved 300 patients previously untreated treated from 2006 through 2013. Eligible had ≤cT2b (T3 excluded according to magnetic resonance imaging), Gleason score (GS) 6 prostate-specific antigen (PSA) level 10-15 ng/mL, or GS 7 PSA <10 were (without hormonal therapy).Median patient age was 64.9 years;...
Magnetic resonance (MR)-guided radiation therapy (MRgRT) is a new technique for treatment of localized prostate cancer (PCa). We report the 12-month outcomes first PCa patients treated within an international consortium (the MOMENTUM study) on 1.5T MR-Linac system with ultrahypofractionated therapy.Patients 5 × 7.25 Gy were identified. Prostate specific antigen-level, physician-reported toxicity (Common Terminology Criteria Adverse Events [CTCAE]), and patient-reported (Quality Life...
In this paper, we address the performance degradation of efficient diffusion models by introducing Multi-architecturE Multi-Expert (MEME). We identify need for tailored operations at different time-steps in processes and leverage insight to create compact yet high-performing models. MEME assigns distinct architectures time-step intervals, balancing convolution self-attention based on observed frequency characteristics. also introduce a soft interval assignment strategy comprehensive...
Radiation therapy (RT) is one of the principal treatment modalities for localized or locally advanced prostate cancer. The two major forms RT cancer are external-beam (EBRT) with a photon proton beam and brachytherapy. With modern conformal techniques EBRT (three-dimensional RT, intensity-modulated image-guided RT) computer-based planning systems brachytherapy, dose can be more precisely delivered to while reducing unnecessary radiation normal tissue. dominant intraprostatic tumor targeted...
Hypofractionated prostate radiotherapy may increase biologically effective dose delivered while shortening treatment duration, but information on patient-reported urinary, bowel, and sexual function after dose-escalated hypofractionated is limited. We report outcomes (PROs) from a randomized trial comparing conventional radiotherapy.Men with localized cancer were enrolled in that men to either conventionally fractionated intensity-modulated radiation therapy (CIMRT, 75.6 Gy 1.8 fractions) or...
Objectives To determine the frequency of disease reclassification and to identify clinicopathological variables associated with it in patients favourable‐risk prostate cancer undergoing active surveillance ( AS ). Patients Methods We assessed 191 men, selected by what may be most stringent criteria used studies yet conducted, who were enrolled a prospective cohort trial. Clinicopathological characteristics analysed multivariate Cox proportional hazards regression model. Key features an...
// Mehmet Asim Bilen 1 , Kenneth R. Hess 2 Matthew T. Campbell 3 Jennifer Wang Russell Broaddus 4 Jose A. Karam 5 John F. Ward Christopher G. Wood Seungtaek L. Choi 6 Priya Rao Miao Zhang Aung Naing 7 Rosale General Diana H. Cauley Sue-Hwa Lin 8 J. Logothetis Louis Pisters Shi-Ming Tu Department of Hematology and Medical Oncology, Winship Cancer Institute Emory University, Atlanta, GA, USA Biostatistics the University Texas MD Anderson Center, Houston, Texas, Genitourinary Oncology Pathology...
Background The purpose of this study was to assess treatment choices among men with prostate cancer who presented at University Texas MD Anderson Cancer Center multidisciplinary (MultiD) clinic compared nationwide trends. Methods In total, 4451 the MultiD from 2004 2016 were analyzed. To trends, authors analyzed 392,710 diagnosed between and 2015 Surveillance, Epidemiology, End Results (SEER) database. primary endpoint choice as a function pretreatment demographics. Univariate analyses...
Proton therapy is a promising but controversial treatment in the management of prostate cancer. Despite its dosimetric advantages when compared with photon radiation therapy, increased cost to patients and insurers has raised questions regarding value. Multiple prospective retrospective studies have been published documenting efficacy safety proton for localized cancer requiring adjuvant or salvage pelvic after surgery. The Particle Therapy Co-Operative Group (PTCOG) Genitourinary...
Intensity modulated proton therapy (IMPT) plans are normally generated utilizing multiple field optimization (MFO) techniques. Similar to photon based IMRT, MFO allows for the utilization of a simultaneous integrated boost in which target volumes treated discrete doses simultaneously, potentially improving plan quality and streamlining assurance treatment delivery. However, may render more sensitive physical uncertainties inherent particle therapy. Here we present clinical examples...