A5101664063- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Cancer Treatment and Pharmacology
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- Cerebrospinal fluid and hydrocephalus
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- Nitric Oxide and Endothelin Effects
- Endometrial and Cervical Cancer Treatments
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Sirtuins and Resveratrol in Medicine
- Nuclear Receptors and Signaling
- Inflammasome and immune disorders
- Acupuncture Treatment Research Studies
- Gynecological conditions and treatments
- Muscle Physiology and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Nutrition and Health in Aging
- Ovarian cancer diagnosis and treatment
- Polyamine Metabolism and Applications
- HVDC Systems and Fault Protection
- Vascular Malformations and Hemangiomas
- Metabolomics and Mass Spectrometry Studies
Xuzhou Medical College
2022-2024
Maternal and Child Health Hospital of Xuzhou
2022
Affiliated Hospital of Xuzhou Medical College
2022
Huntington Medical Research Institutes
2022
Shanghai Sixth People's Hospital
2013-2021
Shanghai Jiao Tong University
2013-2019
Agricultural Research Service - Northeast Area
2019
Houston Methodist
2012-2017
Shandong University
2017
Jinan Central Hospital
2017
Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by selective loss of upper and lower motor neurons. Patients with ALS have persistent peripheral central inflammatory responses including abnormally functioning T cells activated microglia. However, much less known about the gene profile circulating innate immune monocytes in these patients.To characterize transcriptomics patients ALS.Monocytes were isolated from blood 43 22 healthy control...
Abstract Introduction Stroke is a major cause of permanent neurologic damage, with few effective treatments available to restore lost function. Induced pluripotent stem cells (iPSCs) have the potential generate all cell types in vitro and can be generated from stroke patient. Therefore, iPSCs are attractive donor sources genetically identical “patient-specific” hold promise therapy for stroke. In present study, we established four-stage culture system by using serum-free medium retinoic acid...
Radical surgery of primary vaginal carcinoma typically involves partial or complete resection the vagina, and young patients in particular can experience sexual dysfunction after surgery. Vaginoplasty is mandatory for this population, multiple reconstructive techniques have been reported. Here we attempted to determine whether peritoneum a feasible alternative sigmoid colon vaginoplasty performed during radical Between February 2005 July 2009, 12 underwent Federation International Gynecology...
Gliomas are one of the most common malignant brain tumors and bring a big threat to human life as traditional therapy is unsatisfactory. RBM5 was RNA-binding motif protein reported tumor suppressor. But role in gliomas unknown. The mRNA level determined tissues cell lines by real-time quantitative PCR (qRT-PCR) assay while association expression with prognosis analyzed Kaplan-Meier method compared log-rank test. Lentivirus used overexpress cells. MTT BrdU incorporation were determine...
Mitochondrial dysfunction has been implicated as a cause of energy deprivation in heart failure (HF). Herein, we tested individual and combined effects two pathogenic factors nonischemic HF, inhibition nitric oxide synthesis [with l-N(G)-nitroarginine methyl ester (l-NAME)] hypertension angiotensin II (AngII)], on myocardial mitochondrial function, oxidative stress, metabolic gene expression. l-NAME AngII were administered individually combination to mice for 5 wk. Although all treatments...
Objective. Inactivation of NLRP3 inflammasome plays a role in reducing the permeability endothelial cells and improving blood-brain barrier (BBB) dysfunction following traumatic brain injury (TBI). However, mechanism controlling activation remains unclear. This study is aimed at defining miR-29a-5p under TBI. Methods. The scratch model on bEnd.3 microvascular was used as vitro TBI cells. Effects miR-29a mimics inhibitors were observed by examining their action FITC, TEER, protein contents...
The present study aimed to identify microRNAs (miRNAs) that are involved in neuropathic pain and predict their corresponding roles the pathogenesis development process of pain. rat model caused by spared nerve injury (SNI) was established Sprague-Dawley male rats, followed small RNA sequencing L3-L6 dorsal root ganglion. Real-time PCR performed validate differently expressed miRNAs. Functional verification intrathecally injecting animals with miRNA agomir. A total 72 differentially miRNAs...
Metabolic memory (MM) is a major factor in the delayed wound healing observed diabetic patients. While "Nocardia rubrum cell wall skeleton" (Nr-CWS) utilized to enhance macrophage proliferation immune diseases, its impact on MM wounds diabetes unclear. This study demonstrates that transient hyperglycemia leads prolonged damage vascular endothelial cells by decreasing METTL3 expression, leading decreased RNA methylation and impaired cellular metabolism. Remarkably, Nr-CWS application...
Increasing studies indicate that acupuncture can be used for treating vestibular migraine (VM), but current evidence remains inconclusive. Thus, this protocol aims to evaluate the regarding efficacy and safety of VM prophylaxis by conducting a systematic review meta-analysis.Studies will retrieved searching electronic databases from their inception December 2020, including EMBASE, PubMed, Web Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), BioMedical Literature...
Communicating hydrocephalus (CH) is a common neurological disorder caused by blockage of cerebrospinal fluid. In this study, we aimed to explore the potential molecular mechanism underlying CH development.Quantitative proteomic analysis was performed screen differentially expressed proteins (DEPs) between patients with and without CH. A rat model verified Hoechst staining, co-localization target protein neuron detected using immunofluorescence staining. Loss-of-function experiments were...
Heart failure with preserved ejection fraction, characterized by diastolic dysfunction (DD) is most common in post-menopausal women, suggesting a link estrogen (E2). However, the underlying mechanisms are not well understood. In this study we tested how ovariectomy (OVX)-induced E2-deficiency exacerbates DD. Female C57BL6/J mice (12 weeks old) underwent sham or OVX surgery, and were administered either normal drinking water L-N G -Nitroarginine methyl ester (L-NAME, 0.3 mg/ml 1% NaCl...
The nose is an unpaired facial structure. Applying three-dimensional rapid printing to total reconstruction difficult because no paired structure available for reference. In this study, laser scanning was used create a database of normal external noses Han Chinese individuals in East China assist reconstruction.Three-dimensional noses. Patients scheduled nasal had their measurements scaled according head circumference and proportions simulate new reconstructed shape the residual using...
Abstract Blood-brain barrier (BBB) dysfunction is presented during traumatic brain injury (TBI) and dependent upon the activation of NLRP3/Caspase-1 inflammasome pathway. MicroRNA (miRNA) was proved to inhibit signaling pathway by targeting gene expression we predicated in database that miR-29a targets NLRP3. Herein, this study aims define regulating role NLRP3 TBI-induced BBB dysfunction. Our results indicated miR-29a-5p alleviates increased permeability endothelial cell via suppressing...
Objective To observe the clinical efficacy of propranolol and 595 nm pulsed dye laser (PDL) in treatment infantile hemangioma. Methods 26 infants admitted to our hospital from January 2013 2015 with hemangioma underwent oral 2 mg/(kg·d) after excluding taboos. The daily doses were divided equally two parts, taken on time 8: 00 20: 00, when electrocardiograph pulse oxygen monitored recorded persistently. patients discharged it was stable, review blood routine examination, fasting...