A5052979555- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Infections and bacterial resistance
- Nosocomial Infections in ICU
- Thermal Regulation in Medicine
- Acute Ischemic Stroke Management
- Heme Oxygenase-1 and Carbon Monoxide
- Computational Drug Discovery Methods
- COVID-19 diagnosis using AI
- Antibiotic Resistance in Bacteria
- Bioinformatics and Genomic Networks
- Circular RNAs in diseases
- Protein Structure and Dynamics
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
Shanghai Jiao Tong University
2018-2024
Shanghai Sixth People's Hospital
2018-2024
Objective. Inactivation of NLRP3 inflammasome plays a role in reducing the permeability endothelial cells and improving blood-brain barrier (BBB) dysfunction following traumatic brain injury (TBI). However, mechanism controlling activation remains unclear. This study is aimed at defining miR-29a-5p under TBI. Methods. The scratch model on bEnd.3 microvascular was used as vitro TBI cells. Effects miR-29a mimics inhibitors were observed by examining their action FITC, TEER, protein contents...
The present study aimed to identify microRNAs (miRNAs) that are involved in neuropathic pain and predict their corresponding roles the pathogenesis development process of pain. rat model caused by spared nerve injury (SNI) was established Sprague-Dawley male rats, followed small RNA sequencing L3-L6 dorsal root ganglion. Real-time PCR performed validate differently expressed miRNAs. Functional verification intrathecally injecting animals with miRNA agomir. A total 72 differentially miRNAs...
We collected data on ventilator-associated pneumonia (VAP) and hospital-acquired (HAP) induced by Stenotrophomonas maltophilia (SM) Klebsiella pneumoniae (KP) compared differences between two bacteria in mortality, duration of ventilator use, length hospital stay, risk factors for infection.This study aimed to evaluate the prognosis find SM-HAP/VAP versus KP-HAP/VAP intensive care unit (ICU).This retrospective cohort included patients admitted ICU June 2019 2021 diagnosed with or KP-HAP/VAP....
Communicating hydrocephalus (CH) is a common neurological disorder caused by blockage of cerebrospinal fluid. In this study, we aimed to explore the potential molecular mechanism underlying CH development.Quantitative proteomic analysis was performed screen differentially expressed proteins (DEPs) between patients with and without CH. A rat model verified Hoechst staining, co-localization target protein neuron detected using immunofluorescence staining. Loss-of-function experiments were...
Hydrocephalus is a neurological condition caused by an abnormal accumulation of cerebrospinal fluid; pharmacological intervention the disease has been found to elicit variety adverse drug reactions (ADRs) in central nervous system (CNS) unexpectedly targeting certain functional neuroproteins. Here, systematic neuroprotein interactome (SNDI) created for 11 hydrocephalus drugs/metabolites plus 20 control drugs across 518 druggable pockets on surface 472 CNS neuroproteins via large-scale...
Abstract Blood-brain barrier (BBB) dysfunction is presented during traumatic brain injury (TBI) and dependent upon the activation of NLRP3/Caspase-1 inflammasome pathway. MicroRNA (miRNA) was proved to inhibit signaling pathway by targeting gene expression we predicated in database that miR-29a targets NLRP3. Herein, this study aims define regulating role NLRP3 TBI-induced BBB dysfunction. Our results indicated miR-29a-5p alleviates increased permeability endothelial cell via suppressing...
Abstract Aims : To compare Endoscopic Surgery and Robot CAS-R-2 drainage for surgical treatment of basal ganglia hypertensive intracerebral hemorrhage. Methods Fifty consecutive hemorrhage patients were reviewed retrospectively. The primary secondary outcomes 6-months mortality modified Rankin Scale score, which assessed by a multivariate logistic regression mode. Results Compared with the group, 6-month prognosis was significantly higher in endoscopic evacuation group (OR 5.912, 95% CI...
Abstract Communicating hydrocephalus (CH) is a common neurological disorder caused by blockage of cerebrospinal fluid. In this study, we aimed to explore the potential molecular mechanism underlying CH development. Quantitative proteomic analysis was performed screen differentially expressed proteins (DEPs) between patients with and without CH. A rat model verified Hoechst staining, co-localization target protein neuron detected using immunofluorescence staining. Loss-of-function experiments...