A5061715142- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Pleural and Pulmonary Diseases
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Tracheal and airway disorders
- Advanced Radiotherapy Techniques
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Hepatocellular Carcinoma Treatment and Prognosis
- BRCA gene mutations in cancer
- Hepatitis C virus research
- Colorectal and Anal Carcinomas
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Salivary Gland Disorders and Functions
- Cardiomyopathy and Myosin Studies
- Head and Neck Surgical Oncology
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
Guangdong Academy of Medical Sciences
2016-2025
Guangdong Provincial People's Hospital
2019-2025
Southern Medical University
2023-2024
Zhujiang Hospital
2024
Shanghai Jiao Tong University
2024
First Affiliated Hospital Zhejiang University
2021
Guangdong General Hospital
2012-2019
South China University of Technology
2019
Andre Abrasive Articles (Poland)
2017
The efficacy and potential limitations of molecular residual disease (MRD) detection urgently need to be fully elucidated in a larger population non-small cell lung cancer (NSCLC). We enrolled 261 patients with stages I III NSCLC who underwent definitive surgery, 913 peripheral blood samples were successfully detected by MRD assay. Within the population, only six (3.2%) longitudinal undetectable recurred, resulting negative predictive value 96.8%. Longitudinal may define cured. peak risk...
Abstract Developing nanozymes with effective reactive oxygen species (ROS) scavenging ability is a promising approach for osteoarthritis (OA) treatment. Nonetheless, numerous lie in their relatively low antioxidant activity. In certain circumstances, some of these may even instigate ROS production to cause side effects. To address challenges, copper‐based metal–organic framework (Cu MOF) nanozyme designed and applied OA Cu MOF exhibits comprehensive powerful activities (i.e., SOD‐like,...
Importance Uninterrupted targeted therapy until disease progression or intolerable toxic effects is currently the routine for advanced non−small cell lung cancer (NSCLC) involving driver gene variations. However, drug resistance inevitable. Objective To assess clinical feasibility of adaptive de-escalation tyrosine kinase inhibitor (TKI) treatment guided by circulating tumor DNA (ctDNA) achieving complete remission after local consolidative (LCT) in patients with NSCLC. Design, Setting, and...
Abstract This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exhibited resectable stage IIA–IIIB (AJCC 8th edition) NSCLC without EGFR / ALK alterations. Patients received either mono-nivolumab or nivolumab + nab-paclitaxel+ carboplatin for three cycles The primary endpoint was major pathological response (MPR). Key secondary endpoints...
In this study, we evaluated the diagnostic value and molecular characteristics of plasma extracellular vesicles (EVs)-derived miRNAs for patients with solitary pulmonary nodules (SPNs), particularly ground-glass (GGNs). This study was registered at www.clinicaltrials.gov under registration number NCT03230019. Small RNA sequencing performed to assess EVs in 59 patients, including 12 benign (2017, training set). MiRNA profiles 40 an additional individuals were sequenced (2018, validation...
Abstract Early-stage lung adenocarcinoma (LUAD) generally has a favorable prognosis. However, more than 30% of early-stage LUAD cases relapse within 5 years initial treatment, even following complete removal the primary tumor. Identification factors contributing to metastasis is needed develop effective prevention and treatment strategies. Here, we found upregulation xylosyltransferase 1 (XYLT1), glycosyltransferase that initiates biosynthesis sulfated glycosaminoglycan (sGAG) chains, in...
Bladder carcinoma is among the top 10 most frequently diagnosed cancer types in world.As a phytochemical active metabolic, thymoquinone (TQ) extracted from seeds of Nigella sativa, possessing various biological properties wide range diseases.Moreover, outstanding anti-cancer effect TQ attracting increasing attentions.In certain circumstances, moderate autophagy regarded to facilitate adaptation malignant cells different stressors.Conversely, closely linked with mitochondrial membrane...
The management of non-small cell lung cancer (NSCLC) relies on the tumour–node–metastasis (TNM) stage, and treatment regimen differs based N status. Positron emission tomography–computed tomography (PET–CT) has emerged as a powerful imaging tool for detection various cancers with relatively low false-negative rate. We explored predictors to identify N2 disease in PET–CT. A total 284 consecutive cN0 patients peripheral NSCLC who underwent PET–CT scans followed by curative intent resections...
Background Video‐assisted thoracoscopic surgery ( VATS ) lobectomy has emerged as a safe and effective technique for treating early‐stage lung cancer. Novel three‐dimensional, high‐definition 3D HD imaging removed this technical obstacle is increasingly used in laparoscopic surgery. We compared our initial experience of with standard two‐dimensional 2D to identify the advantages disadvantages visualization . Methods The data consecutive patients diagnosed cancer who underwent or bilobectomy...
We aimed to validate the tumor (T) descriptors of visceral pleural invasion (VPI) for T1 tumors (<3 cm) in 8th edition tumor-node-metastasis (TNM) classification system and prognostic value VPI resected T1a tumors.The external cohort consisted 23,501 patients with pN0 non-small cell lung cancer (NSCLC) selected from Surveillance, Epidemiology, End Results (SEER) database (2010 2013). The was investigated using survival curves. internal diagnosed NSCLC between 2011 2013 at Guangdong Lung...
Effective methods for managing patients with solitary pulmonary nodules (SPNs) depend critically on the predictive probability of malignancy.Between July 2009 and June 2011, data gender, age, cancer history, tumor familial smoking status, location, nodule size, spiculation, calcification, border, final pathological diagnosis were collected retrospectively from 154 surgical an SPN measuring 3-30 mm. Each was compared calculated by three predicted models-the Mayo, VA, Peking University (PU)...
Background Since the conception of enhanced recovery after surgery protocols, tubeless strategies have become popular. Herein, we introduce a previously unreported alternative air‐extraction strategy for patients who undergone thoracoscopic wedge resection and explore its feasibility safety. Methods Between January 2015 June 2017, 264 consecutive underwent with different drainage strategies. Patients were divided according to postoperative used: routine chest tube (RT group), complete...
Estimating the growth of pulmonary sub-solid nodules (SSNs) is crucial to successful management them during follow-up periods. The purpose this study (1) investigate measurement sensitivity diameter, volume, and mass SSNs for identifying (2) seek establish a deep learning-based model predict SSNs. A total 2,523 patients underwent at least 2-year examination records retrospectively collected with nodules. 2,358 3,120 from NLST dataset were randomly divided into training validation sets....
In recent years, the lung cancer incidence has grown and population is younger. We intend to find out true detection rate of pulmonary nodules in search for risk factors.Hospital employees ≥40 years old who underwent low-dose computed tomography (CT) screening from January 2019 March 2022 were selected record CT-imaging characteristics, pathology, staging, questionnaires investigate past history, smoking diet, mental health, etc. PM2.5 radiation intake radiation-related occupation received...
Elevated glucose metabolism is a prominent characteristic of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). However, the efficacy inhibiting single target FLS using small molecular inhibitors limited for RA treatment. Herein, synergistic inhibition FLS' survival, proliferation, and activation by combining two inhibitors, diclofenac (DC) lonidamine (LND) was first verified. Subsequently, DC LND were individually conjugated to cystamine-modified hyaluronic acid (HA) prepare...
Abstract OBJECTIVES In recent years, with the advancement of sublobar resection, A safe, painless method for locating peripheral pulmonary nodules is required. Previously, an alternative arterial watershed localization was been introduced to remedy shortcomings preoperative CT-guided or other methods nodules, but its technical limitations were discovered during clinical application. Therefore, we innovated a technique localize non-subpleural using basin analysis target vein and validated...
Aim: Response Evaluation Criteria in Solid Tumors (RECIST) is occasionally insufficient for evaluation. We proposed a new prognostic index (NPI) that combines the standardized uptake value (SUV), metabolic tumor volume (MTV) and RECIST. Methods: In total, 116 patients with lung cancer who underwent consecutive positron emission tomography-computed tomography prior to after initial treatment were included. formulated NPI by estimating hazard ratios of overall survival ∆MTV, ∆SUVmax ∆D (tumor...
: As surgical proficiency and the development of medical techniques have improved, uniportal video-assisted thoracoscopic surgery (VATS) has emerged as a minimally invasive alternative in management lung cancer. The spectrum VATS indications is now almost equal to that conventional VATS. Recent decades witnessed emergence numerous techniques. A significant proportion these be converted into multiport approach even open thoracotomy due difficulty managing upper lobe vein bronchus,...