A5001281921- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Metabolism, Diabetes, and Cancer
- Biological Activity of Diterpenoids and Biflavonoids
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
- Phytoestrogen effects and research
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Retinoids in leukemia and cellular processes
- Phytochemistry and Biological Activities
- Saffron Plant Research Studies
- Adipose Tissue and Metabolism
- Frailty in Older Adults
- Ion Transport and Channel Regulation
- Bioactive natural compounds
- Extracellular vesicles in disease
- Lysosomal Storage Disorders Research
- Signaling Pathways in Disease
- Genetic Associations and Epidemiology
Jimei University
2024-2025
University of Chinese Academy of Sciences
2025
Shenzhen Institutes of Advanced Technology
2025
Chinese Academy of Sciences
2025
Ministry of Agriculture and Rural Affairs
2024
First Affiliated Hospital of Henan University
2016-2023
Henan Bioengineering Technology Research Center
2020-2023
Shanghai Jiao Tong University
2011-2022
Shanghai Sixth People's Hospital
2014-2022
Genomics Research Center, Academia Sinica
2018
The aim of this study was to explore the estrogenic effects extracts from Chinese yam and its effective compounds.The activity investigated by uterine weight gain mice a proliferation assay breast cancer cell lines (MCF-7 cell); comprehensively evaluated serum pharmacology experiment. levels estradiol (E2), follicle stimulating hormone (FSH), luteinizing (LH) were also measured. Western blot analysis antagonist assays with faslodex (ICI182,780), methylpiperidino-pyrazole (MPP), Delta (9)...
Sonodynamic therapy (SDT) is a promising therapeutic modality known for its non-invasiveness, temporal-spatial controllability, and deeper tissue penetration. However, the SDT treatment efficacy still hampered by scarcity of ideal sonosensitizers complex tumor microenvironment (TME). To address these challenges, sono-metabolic nano-composite (TiO2-Au@DON) using metabolic reprogramming prodrugs 6-Diazo-5-oxo-l-norleucine (DON) grafted on TiO2-Au Janus nanoparticles (NPs) fabricated. The...
Aim: To investigate the anti-diabetic activity of amentoflavone (AME) in diabetic mice, and to explore potential mechanisms. Methods: Diabetic mice induced by high fat diet streptozotocin were administered with for 8 weeks. Biochemical indexes tested evaluate its effect. Hepatic steatosis, histopathology change pancreas was evaluated. The glucose metabolic enzymes, expression Akt pAkt, transporter type 4 (GLUT4) immunoreactivity detected. Results: AME decreased level glucose, total...
Abstract Milk‐derived extracellular vesicles (mEVs) are promising therapeutic delivery platforms due to their natural bioactivity, biocompatibility, and ability cross biological barriers. However, analyzing cellular uptake trafficking is limited by existing fluorescent labeling methods, which often cause dye leakage disrupt vesicle integrity. Here, a glycan‐anchored fluorescence strategy for mEVs developed, involving periodate oxidation of surface sialic acids followed aniline‐catalyzed...
The aim of this study was to explore the mechanism by which amentoflavone (AME) improves insulin resistance in a human hepatocellular liver carcinoma cell line (HepG2).A model resistant cells established HepG2 treatment with high glucose and insulin. oxidase method used detect consumption each group. To determine AME cells, enzyme-linked immunosorbent assay (ELISA) western blotting were expression phosphatidyl inositol 3-kinase (PI3K), Akt, pAkt; activity enzymes involved metabolism; levels...
Background and Aim: The presence of malnutrition in hospitalized geriatric patients is associated with an increased risk mortality. This study aimed to examine the performance Nutritional Risk Screening 2002 (NRS2002) Mini Assessment Short Form (MNA-SF) predicting mortality for China. Methods: A prospective analysis was performed 536 aged ≥ 65 years. Nutrition status assessed using MNA-SF NRS2002 scales within 24 hrs admission. Anthropometric measures biochemical parameters were carried out...
Aldosterone and the mineralocorticoid receptor (MR) are critical to maintenance of electrolyte BP homeostasis. Mutations in MR cause aldosterone resistance known as pseudohypoaldosteronism type 1 (PHA1); however, some cases consistent with PHA1 do not exhibit gene mutations, suggesting possibility alternative genetic variants. We observed that G protein-coupled 48 (Gpr48/Lgr4) hypomorphic mutant (Gpr48(m/m)) mice had hyperkalemia increased water loss salt excretion despite elevated plasma...
The escalating prevalence of obesity poses significant health challenges due to its direct association with various diseases. Most existing medications, such as appetite suppressants and fat absorption inhibitors, suffer from limited effectiveness undesirable side effects. Here, inspired by the versatile metabolic effects turmeric, we developed a naturally derived nanoformulation "Reconstructed Turmeric-derived Nanovesicles (Rec-tNVs)" for treatment. Employing quantitative nanoflow...
Abstract Objectives To investigate the antidiabetic, antihyperlipidaemic and antioxidant activity of total flavonoids in Selaginella tamariscina (Beauv.) Spring (TFST) a mouse model diabetes. Methods Normal mice, mice fed with high-fat emulsion diet streptozotocin (STZ)-induced diabetic were treated TFST for 6 weeks. Serum glucose, insulin lipid, hepatic steatosis, production protein visfatin indices evaluated. Key findings significantly decreased concentration fasting blood cholesterol,...
The root of Rehmannia glutinosa (R. glutinosa) is commonly used in various traditional Chinese herbal formulae to ameliorate nephropathy; however, little known about its active component(s) and mechanisms. In the present study, we examined protective effect potential mechanism rehmapicrogenin, a monomeric compound extracted from R. glutinosa, against Adriamycin (ADR)-induced nephropathy (AN) vivo vitro. this an ADR-induced kidney injury model was employed investigate nephroprotective effects...
Renal fibrosis with Renin-angiotensin-aldosterone system (RAAS) activation and oxidative stress are one of the major complications in hypertension. 2-phenylacetamide (PA), a active component Lepidium apetalum Willd. (L.A), has numerous pharmacological effects. Its analogues have effect anti-renal alleviating renal injury. This study aims to explore underlying mechanism PA for regulating SHR based on MAPK pathway mediated RAAS stress.The rats were used as hypertension model, WKY control...
Rehmanniae Radix (RR), an herb with numerous pharmacological effects, is widely used in traditional Chinese medicine for the treatment of blood deficiency syndrome, either alone or combination other herbs. However, mechanism by which processed (PRR) improves enrichment efficacy has not been clearly defined.Ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass (UPLC-Q-TOF/MS) and biochemical methods were combined explore hematopoietic functional mechanisms PRR on a...
Lepidium apetalum Willd has been used to reduce edema and promote urination. Cis-desulfoglucotropaeolin (cis-DG) trans-desulfoglucotropaeolin (trans-DG) were isolated from Willd, caused a significant increase in cell viability hypertonic model NRK52e cells. In the model, cis-DG trans-DG significantly promoted of cells inhibited elevation Na⁺ supernatant, renin-angiotensin-aldosterone (RAAS) system, reduced levels angiotensin II (Ang II) aldosterone (ALD), lowered aquaporin-2 (AQP2) Na⁺-K⁺...
A new apiose-containing kaempferol trioside, kaempferol-3-O-α-L-rhamnosyl-(1‴ → 6″)-O-β-D-galactopyranosyl-7-O-β-D-apiofuranoside, along with 16 known compounds, were isolated from 50% acetone extract of Silphium perfoliatum L. Their structures elucidated by acid hydrolysis and spectroscopic techniques including UV, IR, MS, ¹H, ¹³C, 2D-NMR. In addition, the pharmacological activity compound 1 was tested HepG2 Balb/c mice (splenic lymphocytes thymic lymphocytes) in vitro, it exhibited...
To investigate the protective effect of Oligosaccharides composition Descurainiae sophia on doxorubicin-induced heart failure in rats, and to study its mechanism. A rat model was established 180−220 g male Sprague-Dawley rats by low-dose intraperitoneal injection doxorubicin for 6 weeks. Four weeks after continuous administration, echocardiography used detect left ventricular end diastolic diameter (LVEDD) systolic (LVESD) each group, short axis shortening rate (LVFS) ejection fraction...
Abstract Objectives To investigate the effects of geniposide in an iridoid found Gardenia jasminoides var. radicans Makino (GJRM) spontaneous hypertensive rat (SHR) and explore possible mechanisms. Methods In this study, we detected content GJRM by high-performance liquid chromatography (HPLC). Then, used acute diuretic experiments to determine whether has effect. Moreover, carried out on SHR further study mechanism hypertension, while real-time PCR, Western blot immunohistochemistry were...