A5035658927- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Natural product bioactivities and synthesis
- Sepsis Diagnosis and Treatment
- Chromatography in Natural Products
- Multiple Myeloma Research and Treatments
- Gastroesophageal reflux and treatments
- Blood groups and transfusion
- Traditional and Medicinal Uses of Annonaceae
- Cancer, Hypoxia, and Metabolism
- Chemical synthesis and alkaloids
- Gout, Hyperuricemia, Uric Acid
- Retinoids in leukemia and cellular processes
- Gut microbiota and health
- Phytochemistry and Biological Activities
- Computational Drug Discovery Methods
- Chronic Lymphocytic Leukemia Research
- Alcohol Consumption and Health Effects
- Medicinal Plants and Neuroprotection
First Affiliated Hospital of Henan University
2017-2023
Henan Bioengineering Technology Research Center
2021
Qujing Normal University
2020
Xian Yang Central Hospital
2020
State Council of the People's Republic of China
2018
Abstract Objectives Weight reduction may reduce serum uric acid (SUA). This study aimed to examine the changes of SUA before and after bariatric surgery in patients with obesity or without hyperuricaemia gout. Methods is a retrospective analysis 147 routinely collected data on hospital who underwent surgery. The body weight were measured at baseline 1–7 days, 1, 3, 6 12 months. Results mean (95% CI) was 30.7 (28.7, 32.7) kg 1 year (P < 0.001). decreased rapidly from 419.0 (400.1,...
This integrated metabolomic approach interpreted the effects of Chinese yam on septic cardiomyopathy and roles its major active components.
A UPLC-QTOF-MS based metabolomics research was conducted to explore potential biomarkers which would increase our understanding of the model and assess integral efficacy Descurainia sophia seeds extract (DS-A). Additionally, DS-A split into five fractions in descending order polarity, were utilized illustrate mechanism together. The 26 identified mainly related disturbances phenylalanine, tyrosine, tryptophan, purine, arginine, proline metabolism. Furthermore, heat map, hierarchical cluster...
The efficacy of Rehmannia Radix changes after processing. However, the precise effect processing on properties is an intricate topic, as this cannot be explained by traditional methods. purpose study was to investigate how methods influence Radix, well in body function administering dried (RR) and processed (PR) using a metabolomics approach. In addition, principal component analysis orthogonal partial least-squares discriminant models were generated SIMCA-P 14.0 evaluate RR PR. Potential...
A UPLC-Q-TOF/MS-based metabolomics study was carried out to explore the intervening mechanism of Corallodiscus flabellatus (Craib) B. L. Burtt (CF) extract on Alzheimer’s disease (AD). The AD model group consisted senescence-accelerated mouse prone 8 (SAMP8) mice, and control resistant 1 (SAMR1) mice. UPLC-Q-TOF/MS detection, multivariate statistical analysis, pathway enrichment were jointly performed research change in metabolite profiling urine result suggested that SAMP8 mice...
This study aimed to investigate the glucose and lipid metabolism improving effect of total flavonoids from Selaginella tamariscina (Beauv.) Spring (TFST) on db/db mice, its mechanism action.The mice were divided into 5 groups: normal group (NC), diabetic (DM), gliclazide (GZ), DM+TFST (110 mg/kg), (220 mg/kg). The body weight, blood glucose, INS, GC, TC, TG, LDL, HDL detected. HE staining was used observe liver pancreas. Urine tested by UPLC-QTOF-MS metabolic differences each group, coupled...
: Primary plasma cell leukemia (PPCL) is one of the most challenging diseases for hematologists. A 65-year-old Chinese male with a history chronic kidney disease and anemic appearance was admitted. He diagnosed leukemia. Peripheral blood cells smearing showed piles cloud-like agglutination. EDTA-dependent agglutination rare phenomenon in vitro. We reported case characterized by agglutination, which has never been reported. This reminded laboratory physicians who master analyzer should have...