A5001003076- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Pharmacological Effects of Natural Compounds
- Ginger and Zingiberaceae research
- Chronic Kidney Disease and Diabetes
- Cholesterol and Lipid Metabolism
- Ovarian function and disorders
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Saffron Plant Research Studies
- Traditional Chinese Medicine Analysis
- Birth, Development, and Health
- Inflammatory mediators and NSAID effects
- Cardiac Ischemia and Reperfusion
- Sirtuins and Resveratrol in Medicine
- Biological Activity of Diterpenoids and Biflavonoids
- Retinoids in leukemia and cellular processes
- Bone and Joint Diseases
- Peroxisome Proliferator-Activated Receptors
- Proteins in Food Systems
- Metabolism, Diabetes, and Cancer
- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Apelin-related biomedical research
- Menstrual Health and Disorders
Henan Bioengineering Technology Research Center
2020-2024
First Affiliated Hospital of Henan University
2017-2024
Bozhou People's Hospital
2022
Henan Agricultural University
2022
Hubei University of Technology
2021
Yangzhou University
2020-2021
First Affiliated Hospital of Jinan University
2021
Huazhong Agricultural University
2016-2017
Henan University of Traditional Chinese Medicine
2016
Nanjing Tech University
2014
Aim: To investigate the anti-diabetic activity of amentoflavone (AME) in diabetic mice, and to explore potential mechanisms. Methods: Diabetic mice induced by high fat diet streptozotocin were administered with for 8 weeks. Biochemical indexes tested evaluate its effect. Hepatic steatosis, histopathology change pancreas was evaluated. The glucose metabolic enzymes, expression Akt pAkt, transporter type 4 (GLUT4) immunoreactivity detected. Results: AME decreased level glucose, total...
The aim of this study was to explore the mechanism by which amentoflavone (AME) improves insulin resistance in a human hepatocellular liver carcinoma cell line (HepG2).A model resistant cells established HepG2 treatment with high glucose and insulin. oxidase method used detect consumption each group. To determine AME cells, enzyme-linked immunosorbent assay (ELISA) western blotting were expression phosphatidyl inositol 3-kinase (PI3K), Akt, pAkt; activity enzymes involved metabolism; levels...
Our study was designed to explore the function and mechanism of taxifolin on glucose metabolism water-salt in kidney with metabolic syndrome (MS) rats. Spontaneous hypertensive rats were induced by fructose establish MS model. Systolic blood pressure (SBP) homeostasis model assessment insulin resistance (HOMA-IR) measured after 7 weeks continuous administration taxifolin. Kidney injury indices histopathological evaluation done. The apoptosis rate primary cells detected flow cytometry....
Abstract This study aimed to determine the effect of initial pH and temperature on whey protein gel formation via Maillard reaction, including changes in structure, rheological texture properties. The color glucose gels were not significant with increasing heat temperature. High alkaline conditions promoted exposure hydrophobic groups such as –SH, which accelerated aggregation formation. Moreover, increased particle size additional contributed higher elastic modulus ( G ′) gel. Fluorescence...
Doxorubicin (DOX) is a highly effective chemotherapeutic that for various tumours. However, the clinical application of DOX has been limited by adverse reactions such as cardiotoxicity and heart failure. Since DOX-induced irreversible, drugs to prevent are needed.This study aimed investigate effect total flavonoids Selaginella tamariscina (P.Beauv.) Spring (TFST) on doxorubicin-induced cardiotoxicity.The present established models in C57BL/6 mice treated with (cumulative dose: 20 mg/kg body...
Abstract The aim of the work was to investigate effects acacetin on endothelial dysfunction and aortic fibrosis in insulin-resistant SHR rats explore its mechanism. Seven-week-old male spontaneously hypertensive (SHR) were selected establish a rat model hypertension with insulin resistance induced by 10% fructose. nuclear factor kappa B p65 (NF-κB p65) Collagen I observed Immunohistochemistry. Immunofluorescence used observe estrogen receptor-alpha (ERα), receptor-beta (ERβ), G...
Background and objectives Cyclophosphamide (CP) is widely used as a chemotherapy drug for the treatment of malignant tumors autoimmune diseases, but it has strong toxic side effects can cause permanent damage to ovaries, which affects women's quality life. This study aimed investigate anti-premature ovarian failure protective effect allantoin isolated from Dioscorea opposita Thunb. Methods Firstly, 75 mg/kg CP was injected into rats establish an in vivo model premature (POF). The POF were...
This study aimed to explore the effects and mechanisms of total extracts from Anthriscus sylvestris on pulmonary hypertension in rats. Sixty male SD rats were divided into normal(NC) group, model(M) positive drug sildenafil(Y) low-dose A. sylvestris(ES-L) medium-dose sylvestris(ES-M) high-dose sylvestris(ES-H) group. On day 1, intraperitoneally injected with monocrotaline(60 mg·kg~(-1)) induce hypertension, rat model was established 28. From days 15 28, intragastric administration respective...
Dihydroquercetin (DHQ) is commonly used as a dietary additive, but its activity in improving brain injury with metabolic syndrome (MS) remains known. In present study, the MS rat model was induced using 10 % fructose water. The apoptosis rate of primary cells detected. HIF-1α/AKT/NR2B signalling pathway, levels KEAP1/NRF2, HO-1 and NQO-1 were vitro experiments performed H2O2-stimulated PC-12 cells. effect DHQ on rates cell survival After silencing HIF-1α, we further elucidate mechanism...
1. Chicken muscle is an important factor in meat quality and its development controlled by a complex regulatory network.2. The following study examined the expression of miR-30a-3p Gushi chicken breast tissue found that it was differentially expressed at different embryonic stages, reaching peak 14-day-old embryo (E14).3. effect on primary myoblasts (CPMs) explored. Results from both cell counting kit-8 (CCK-8) 5-ethynyl-2'-deoxyuridine (EdU) showed this can inhibit proliferation myoblasts,...
Lepidium apetalum Willd has been used to reduce edema and promote urination. Cis-desulfoglucotropaeolin (cis-DG) trans-desulfoglucotropaeolin (trans-DG) were isolated from Willd, caused a significant increase in cell viability hypertonic model NRK52e cells. In the model, cis-DG trans-DG significantly promoted of cells inhibited elevation Na⁺ supernatant, renin-angiotensin-aldosterone (RAAS) system, reduced levels angiotensin II (Ang II) aldosterone (ALD), lowered aquaporin-2 (AQP2) Na⁺-K⁺...
Duzhong Butiansu (DZBTS) prescription contains many traditional Chinese medicines and has been shown to have a curative effect on male fertility. However, the efficacy mechanism of DZBTS in treatment infertility induced by heat stress not reported. The aim present study is elucidate spermatogenic function model rats.Male Wistar rats (280-320 g) were given different doses (0.4853 g/kg/d or 0.9707 g/kg/d), Shengjing capsule (0.56 double distilled water for 15 days. A 43°C hot bath 30 minutes...
Introduction: Hypertension is closely related to myocardial injury. Long-term hypertension can cause Therefore, it very important find drugs treat injury caused by hypertension. The aim of present study investigate the effects and mechanisms geniposide on injuries in spontaneously hypertensive rats (SHR) H9c2 cells induced NaCl solution. Materials Methods: Male Wistar–Kyoto (WKY) SHR were given different doses (25 mg/kg/d or 50 mg/kg/d) distilled water for three consecutive weeks. Meanwhile,...
Renal fibrosis with Renin-angiotensin-aldosterone system (RAAS) activation and oxidative stress are one of the major complications in hypertension. 2-phenylacetamide (PA), a active component Lepidium apetalum Willd. (L.A), has numerous pharmacological effects. Its analogues have effect anti-renal alleviating renal injury. This study aims to explore underlying mechanism PA for regulating SHR based on MAPK pathway mediated RAAS stress.The rats were used as hypertension model, WKY control...
We investigated the protective effects of ephedra herb (HEPH) on adriamycin-induced testicular toxicity in rats and explored potential mechanisms underlying these effects.A rat model adriamycin injury was established, sperm motility-related indicator oxidative stress levels testis were evaluated. Serum sex hormones cell apoptosis detected by enzyme-linked immunosorbent assay flow cytometry, respectively. Western blotting (WB), immunofluorescence analyses, reverse transcription-polymerase...