A5100451811- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Birth, Development, and Health
- Child Nutrition and Water Access
- Congenital Diaphragmatic Hernia Studies
- Breastfeeding Practices and Influences
- Metabolism and Genetic Disorders
- Trace Elements in Health
- Biochemical Analysis and Sensing Techniques
- Genomics and Rare Diseases
- Ultrasound in Clinical Applications
- Food composition and properties
- Bacterial Infections and Vaccines
- Genetics and Neurodevelopmental Disorders
- Bone health and osteoporosis research
- Gut microbiota and health
- Neonatal Health and Biochemistry
- Cell Adhesion Molecules Research
- Congenital gastrointestinal and neural anomalies
- Diet and metabolism studies
- Fecal contamination and water quality
- Protein Hydrolysis and Bioactive Peptides
- Phagocytosis and Immune Regulation
Children's Hospital of Fudan University
2014-2025
Hubei University of Medicine
2025
Peking University
2024
Obstetrics and Gynecology Hospital of Fudan University
2022-2024
Shaanxi University of Science and Technology
2023
Shanghai University of Traditional Chinese Medicine
2023
Guangzhou University of Chinese Medicine
2016-2023
Capital Medical University
2023
Traditional Chinese Medicine Hospital of Kunshan
2023
Chinese Center For Disease Control and Prevention
2022
Objectives Central nervous system (CNS) infection has a high incidence and mortality in neonates, but conventional tests are time-consuming have low sensitivity. Some rare genetic diseases may some similar clinical manifestations as CNS infection. Therefore, we aimed to evaluate the performance of metagenomic next-generation sequencing (mNGS) diagnosing neonatal explore etiology suspected by combining mNGS with whole exome (WES). Methods We prospectively enrolled neonates who were admitted...
Nursing interns play a crucial role in shaping the future nursing workforce, as their professional identity is closely linked to workplace retention rates and patient outcomes. Thus, investigating factors that influence interns' important. To evaluate relationship between psychological capital, stress, micro-learning environment, among interns. This was cross-sectional study. The sample consisted of 388 from 8 comprehensive teaching hospitals across five cities Hubei Province March April...
This study was designed to investigate the associations among ultrasonic backscatter, bone densities, and microstructure in bovine cancellous bone. Ultrasonic backscatter measurements were performed on 33 specimens with a 2.25-MHz transducer. apparent parameters ("apparent" means not compensating for attenuation diffraction) calculated optimal signals of interest. The results showed that significantly related densities ( R2 = 0.17 -0.88 ). After adjusting correlations by mineral density...
As one of the essential nutrients for human body, minerals participate in various physiological activities body and are closely related to many cancers. However, population study on glioma is not sufficient.The purpose this was evaluate relationship between five dietary glioma.A total 506 adult patients with healthy controls were matched 1:1 according age (±5 years) sex. The food intake subjects past year collected through frequency questionnaire, intakes calcium, magnesium, iron, zinc,...
The management of enteral nutrition in very preterm infants (VPIs) is still controversial, and there no consensus on the optimal time point after birth at which can be started. aim this study was to investigate effect early initiation short-term clinical outcomes VPIs.Data (n = 2514) born before 32 wk gestation were collected from 28 hospitals located seven different regions China. Based whether feeding initiated within or 24 h since birth, divided into an (EIEF) group a delayed (DIEF)...
Abstract Background Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades, not much progress has been made in its treatment or prevention. This study aimed to analyze risk factors for LO-NEC, impact LO-NEC on short-term outcomes very infants (VPIs) with focus nutrition different onset times. Method Clinical data VPIs were retrospectively...
Ultrasonic backscatter technique has shown promise as a noninvasive cancellous bone assessment tool. A novel ultrasonic diagnostic (UBBD) instrument and an in vivo application for neonatal evaluation are introduced this study. The UBBD provides several advantages, including noninvasiveness, non-ionizing radiation, portability, simplicity. In study, the signal could be measured within 5 s using UBBD. measurements were performed on 467 neonates (268 males 199 females) at left calcaneus. was...
Lung ultrasound (LUS) is a useful tool for assessing the severity of lung disease, without radiation exposure. However, there little data on practicality LUS in bronchopulmonary dysplasia (BPD) and evaluating short-term clinical outcomes. We adapted score to evaluate BPD assess reliability mLUS correlated with outcomes.Prospective diagnostic accuracy study was designed enroll preterm infants gestational age < 34 weeks. ultrasonography performed at 36 weeks postmenstrual age. The predictive...
Low birth weight is associated with an increased risk of adverse outcomes in many diseases adult life. We investigated the expression IGF-II and status differentially methylated regions (DMR) small for gestational age (SGA) infants after birth.Plasma IGF-II, receptor (IGF2R), IGF-I, IGF-binding protein 3 (IGFBP3) levels were measured 150 newborn infants. These included 30 term appropriate (AGA), SGA, large (LGA), preterm AGA, SGA H19 IGF2 mRNA quantified by fluorescence quantitative...
Early-life stress (ELS) was found to increase the risk of adolescent depression, and clinical evidence indicated that eicosapentaenoic acid (EPA) decreased in patients with but underlying mechanisms are unclear. Here, we utilized an ELS model maternal separation early weaning explore protective role EPA depression. We induced depression-like behavior rather than anxiety-like mice. RNA-sequencing results showed changed transcription pattern liver, including 863 upregulated genes 971...
Abstract Different sowing dates mainly influence the growth of wheat by changing insolation duration and accumulated temperature. But underlying mechanism accumulation starch from different is still unclear. This field study conducted to determine relationship between physicochemical properties date. Results show that amyloplasts greatly affected With postponement time, content A‐type granules in grains significantly increases C‐type decreases. Delaying date decreases amylose. The swelling...
Galloway-Mowat syndrome type 3 (GAMOS3) is an extremely rare and severe autosomal-recessive disease characterized by early-onset nephrotic (NS), microcephaly neurological impairment. Reported GAMOS cases have gradually increased since pathogenic OSGEP variants were identified as the aetiology in 2017.Using whole-exome sequencing a data analysis process established Children's Hospital of Fudan University, clinical molecular features infants with mutations summarized. Literature regarding...
Abstract Objective Nutritional deficiency soon after birth is a risk factor of chronic lung disease (bronchopulmonary dysplasia, BPD). Afflicted infants are further prone to inadequate growth during hospitalization (extrauterine restriction, EUGR). This multi-center retrospective study investigated factors EUGR, specifically in very preterm with BPD. Method Data BPD who were born less than 32 weeks gestation ( n = 1010) collected from 7 regions China. All non-small for gestational age at...
Necrotizing enterocolitis (NEC) is the most common gastrointestinal (GI) medical/surgical emergency of newborn and a leading cause preterm neonate morbidity mortality. NEC challenge to diagnose since it often shares similar clinical features with neonatal sepsis. In present study, plasma protein profiling was compared among NEC, sepsis control cohorts using gel electrophoresis, immunoblot mass spectrometry. We observed significant impairment in formation fibrinogen-γ dimers (FGG-dimer)...
To validate a three-step protocol that assesses the clinical risk associated with using blood glucose monitoring systems (BGMS) in neonates for management of dysglycaemia.The validation approach included confirmation accuracy reference method National Institute Standards and Technology (NIST) standards, assessment analytical performed on whole collected from paediatric patients routinely tested heel stick capillary samples 147 new-born babies admitted to intensive care. BGMS measurements...
Abstract Background To analyze the real-world growth pattern of very premature infants (VPI) with small for gestational age (SGA) after birth by using ΔZ value weight at discharge. Methods The clinical data were collected from 28 hospitals in China September 2019 to December 2020. They divided into EUGR(Extrauterine Growth Restriction) and non-EUGR group according criterion discharge < –1.28. Results This study included 133 eligible VPI SGA. Following value, incidence EUGR was 36.84%...
Abstract Background Studies of microbiota composition infants with small intestinal ostomy due to various etiologies are limited. Here, we characterized the neonates ileostomy resulting from distinct primary diseases. Methods Fifteen patients necrotizing enterocolitis, eight meconium peritonitis, and seven Hirschsprung’s disease were included in study. The caused by these diseases was studied. Results Microbial diversity neonatal fluid generally low, dominated members Proteobacteria...
Lung ultrasound (LUS) is a bedside technique that can be used on diagnosis and follow-up of neonatal respiratory diseases. However, there are rare reports the features bronchopulmonary dysplasia (BPD) which one most common chronic lung diseases in preterm infants.To describe different BPD levels, to investigate value evaluating moderate-to-severe BPD.In this prospective cohort study, newborns less than 37 weeks' gestational age intensive care unit (NICU) were included. The LUS...
Objective To investigate the incidence and related factors of extrauterine growth retardation (EUGR) “true EUGR” in very preterm infants (VPI) from different regions China. Materials methods Clinical data VPI were prospectively collected 28 hospitals seven China September 2019 to December 2020. The divided into a small for gestational age (SGA) group or non-SGA at birth, with 36 weeks gestation discharge being further EUGR non-EUGR group. Infants defined as EUGR.” general information VPI,...