A5101837450- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Neonatal and fetal brain pathology
- Ultrasound in Clinical Applications
- Nanoparticle-Based Drug Delivery
- Congenital Heart Disease Studies
- Retinopathy of Prematurity Studies
- Extracellular vesicles in disease
- Sepsis Diagnosis and Treatment
- MicroRNA in disease regulation
- Tracheal and airway disorders
- Mesenchymal stem cell research
- Traumatic Brain Injury and Neurovascular Disturbances
- Organ Transplantation Techniques and Outcomes
- Birth, Development, and Health
- Neonatal and Maternal Infections
- Preterm Birth and Chorioamnionitis
- Rheumatoid Arthritis Research and Therapies
- Clinical Nutrition and Gastroenterology
- Congenital Diaphragmatic Hernia Studies
- Nanoplatforms for cancer theranostics
- Retinal Imaging and Analysis
- Spondyloarthritis Studies and Treatments
- Pancreatic function and diabetes
- Cardiac, Anesthesia and Surgical Outcomes
Chengdu Women's and Children's Central Hospital
2013-2024
University of Electronic Science and Technology of China
2019-2024
Jiangnan University
2024
Wuxi Fourth People's Hospital
2017-2024
Third Affiliated Hospital of Sun Yat-sen University
2013-2015
Sun Yat-sen University
2013-2015
Hebei Agricultural University
2015
Liaoning University of International Business and Economics
2013
Bayi Children's Hospital
2013
Peking University
2007
BackgroundRetinopathy of prematurity (ROP) is the leading cause childhood blindness worldwide. Automated ROP detection system urgent and it appears to be a safe, reliable, cost-effective complement human experts.MethodsAn automated called DeepROP was developed by using Deep Neural Networks (DNNs). divided into identification grading tasks. Two specific DNN models, i.e., Id-Net Gr-Net, were designed for tasks, respectively. To develop DNNs, large-scale datasets retinal fundus images...
Retinopathy of Prematurity (ROP) is a retinal vasproliferative disorder disease principally observed in infants born prematurely with low birth weight. ROP an important cause childhood blindness. Although automatic or semi-automatic diagnosis has been conducted, most previous studies have focused on "plus" disease, which indicated by abnormalities vasculature. Few reported methods for identifying the "stage" disease. Deep neural networks achieved impressive results many computer vision and...
Abstract Novel acid‐labile, thermoresponsive methacrylamide‐based (co)polymers with pendent ortho ester groups were prepared by free radical polymerization of N ‐(2‐methoxy‐1,3‐dioxan‐5‐yl) methacrylamide (NMM) and ‐(2‐ethoxy‐1,3‐dioxan‐5‐yl)methacrylamide (NEM). These polymers are both acid‐sensitive in aqueous solution, which was proved transmittance measurements, fluorescence, 1 H NMR spectroscopy. The LCSTs the shifted to higher temperature increasing content more hydrophilic NMM units....
Abstract Background Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades, not much progress has been made in its treatment or prevention. This study aimed to analyze risk factors for LO-NEC, impact LO-NEC on short-term outcomes very infants (VPIs) with focus nutrition different onset times. Method Clinical data VPIs were retrospectively...
The aim of this study was to describe the epidemiology prelabour rupture membranes (PROM) in China and assess association between clinical practice following guidelines early neonatal infections.
The effective treatment for cerebral ischemia has not yet been established. Hepatocyte growth factor (HGF) is a potent pleiotropic cytokine that involved in cell and tissue regeneration, including the central nervous system. Studies have demonstrated an exogenous administration of HGF protects brain from ischemic damage. In response to binding receptor c‑Met, activates downstream signaling pathways (including phosphatidylinositol 3-kinase/Akt, Ras/MAPK signal transducer activator...
Objectives The purpose of this study was to reveal the correlation between superior mesenteric artery (SMA) blood flow in first 12 hours life and risk necrotizing enterocolitis (NEC) preterm neonates. Methods We conducted a prospective study. There were 104 neonates included our SMA each neonate measured during if hemodynamic situation stable. results Doppler ultrasound confidential neonatologists nurses. All demographics, comorbidities, outcomes recorded analyzed. Results Among all...
The management of enteral nutrition in very preterm infants (VPIs) is still controversial, and there no consensus on the optimal time point after birth at which can be started. aim this study was to investigate effect early initiation short-term clinical outcomes VPIs.Data (n = 2514) born before 32 wk gestation were collected from 28 hospitals located seven different regions China. Based whether feeding initiated within or 24 h since birth, divided into an (EIEF) group a delayed (DIEF)...
Hyperbaric oxygen therapy for the treatment of neonatal hypoxic-ischemic brain damage has been used clinically many years, but its effectiveness remains controversial. In addition, mechanism this potential neuroprotective effect unclear. This study aimed to investigate influence hyperbaric on proliferation neural stem cells in subventricular zone Sprague-Dawley rats (7 days old) subjected damage. Six hours after modeling, were treated with once daily 7 days. Immunohistochemistry revealed...
Brain microvascular endothelial cells (BMECs) are a major component of the blood-brain barrier that maintains brain homeostasis. Preserving and restoring normal biological functions BMECs can reverse or reduce injury. Endothelial progenitor (EPCs) may promote vascular remodeling restore function. As novel vehicle for cell-cell communication, microvesicles (MVs) have varied functions. The present study investigated effects EPC-derived MVs (EPC-MVs) on in vitro . We isolated from supernatant...
Abstract To find the risk of time thresholds PROM for infectious diseases term neonates. A multi-center prospective cohort study including pregnancies with at a single fetus were conducted. Time duration from to delivery examined in 2-h increments assess rates neonatal diseases. 7019 included study. Neonatal pneumonia and sepsis most frequent neonates born mother term. Rates early-onset varied significantly when comparing length greater than 16 h vs. less (for EOP 3 days life, adjusted OR...
Ankylosing spondylitis (AS; MIM 106300) is a common rheumatic disease with strong genetic components affecting approximately 0.3% of the population. The exact mechanism AS remains elusive. Our previous study showed that could be transmitted in an autosomal dominant inheritance mode and 6-cM candidate region located on chromosome 2q36.1-36.3 was mapped Chinese family. Mutation screening conducted within family other by sequencing, novel mutation will further validated families, sporadic cases...
Abstract Background To analyze the real-world growth pattern of very premature infants (VPI) with small for gestational age (SGA) after birth by using ΔZ value weight at discharge. Methods The clinical data were collected from 28 hospitals in China September 2019 to December 2020. They divided into EUGR(Extrauterine Growth Restriction) and non-EUGR group according criterion discharge < –1.28. Results This study included 133 eligible VPI SGA. Following value, incidence EUGR was 36.84%...
Endothelial progenitor cells (EPCs) have protective roles in ischemic injury due to their ability improve endothelial function and modulate angiogenesis. Microvesicles (MVs) are small membrane particles released by various cell types, including EPCs, which affect target transferring carried genetic information, microRNAs (miRNAs/miRs). Depending on the stimuli MVs exert different functions. In present study, oxygen-glucose deprivation (OGD) was used mimic ischemic-hypoxic (HI) insult, where...
Abstract Necrotizing enterocolitis (NEC) is a serious complication of premature infants, portal venous gas (PVG) under X‐ray, and ultrasound typical manifestation this disease. We report case very low birth weight (VLBW) infant with PVG unexpectedly detected by before the onset NEC. After positive result, clinical manifestations, lab tests confirmed diagnosis This first similar case, demonstrating value ultrasonography in prediction or early NEC, which may change our understanding disease...
Objective To investigate the incidence and related factors of extrauterine growth retardation (EUGR) “true EUGR” in very preterm infants (VPI) from different regions China. Materials methods Clinical data VPI were prospectively collected 28 hospitals seven China September 2019 to December 2020. The divided into a small for gestational age (SGA) group or non-SGA at birth, with 36 weeks gestation discharge being further EUGR non-EUGR group. Infants defined as EUGR.” general information VPI,...
Objectives To determine the COVID-19 vaccination rate in preterm-born children aged 3–7 China and influential factors, identify vaccination-related adverse reactions, clarify reasons behind parental refusal of to their children. Methods This cross-sectional study was conducted parents different regions through WeChat. Results Of 1,924 Chinese included this study, 1,552 (80.7%) had been vaccinated against COVID-19, with a higher eastern China. Children older than 4 years, kids kindergartens...