A5013884746- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Birth, Development, and Health
- Congenital Diaphragmatic Hernia Studies
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Clinical Nutrition and Gastroenterology
- Neuroscience of respiration and sleep
- Parasitic Infections and Diagnostics
- Pneumonia and Respiratory Infections
- Pediatric health and respiratory diseases
- Breastfeeding Practices and Influences
- Respiratory Support and Mechanisms
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Respiratory viral infections research
- Congenital Heart Disease Studies
- Antibiotics Pharmacokinetics and Efficacy
- Genetic Syndromes and Imprinting
- Neonatal and Maternal Infections
- Congenital heart defects research
- Cardiovascular Conditions and Treatments
- Child Nutrition and Feeding Issues
- Global Maternal and Child Health
- Epigenetics and DNA Methylation
Peking University
2015-2025
Peking University Third Hospital
2016-2025
Xiamen Maternal and Child Health Hospital
2022
Xiamen University
2022
Peking Union Medical College Hospital
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
National Institute for Parasitic Diseases
2011
Chinese Center For Disease Control and Prevention
2010
The outcome of preterm infants has been varied in different hospitals and regions developing countries. Regular clinical monitor are needed to know the effects health care. This study aimed describe survival morbidity rates extreme very 15 neonatal-intensive care China.Data were collected from January 1, 2013 December 31, 2014 for neonates with gestational age (GA) between 24 31 complete weeks born our collaborative group. primary outcomes major morbidities prior hospital discharge. Major...
Abstract Background It is proposed that the development of parenteral nutrition-associated cholestasis (PNAC) was significantly associated with preterm birth, low birth weight, infection, etc.; however, etiology and pathogenesis PNAC are not fully understood. Most studies examining PNAC-associated risk factors were single-center relatively small sample sizes. Objective To analyze in infants China. Methods This a retrospective multicenter observational study. Clinical data on effect multiple...
With the progress of perinatal medicine and neonatal technology, more extremely low birth weight (ELBW) survived all over world. This study was designed to investigate short-term outcomes ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in mainland China.All admitted 26 NICUs with a (BW) < l000 g were included between January l, 2011 December 31, 2011. All data collected retrospectively from clinical records by prospectively questionnaire. The each NICU transmitted main...
Abstract Background With the spread of COVID-19 from Wuhan, Hubei Province to other areas country, medical staff in Fever Clinics faced challenge identifying suspected cases among febrile patients with acute respiratory infections. We aimed describe prevalence and clinical features as compared pneumonias etiologies a Clinic Beijing. Methods In this single-center, retrospective study, 342 pneumonia were diagnosed Peking University Third Hospital between January 21 February 15, 2020. From...
While prepregnancy overweight or obesity is known to negatively impact maternal health, its effect on twin infants not well understood. Therefore, we conducted a nationwide, multicenter retrospective study investigate the association between weight and health outcomes in twins. This collected data from 22 healthcare units across 12 regions China January 2018 December 2020. To control for confounding factors, multiple logistic regression, propensity score matching (PSM), inverse probability...
Individuals with intrauterine growth retardation (IUGR) are prone to insulin resistance, whereas the underlying molecular mechanisms remain unclear. In this study, we investigated if PI3K/Akt signaling pathway in skeletal muscle tissues involves resistance IUGR offsprings, particularly ones catch-up growth. An rat model was established by feeding rats an isocaloric (30.50 Kcal/g) diet containing 8% protein (low-protein diet) from day 1 of pregnancy until birth their pups. Glucometabolic...
Abstract Objective This study compared the clinical effects of two different lipid emulsions in premature infants with gestational age < 32 weeks (VPI) or birth weight 1500 g (VLBWI) to provide an evidence-based medicine basis for optimizing intravenous emulsion. Methods was a prospective multicenter randomized controlled study. A total 465 VPIs VLBWIs, admitted neonatal intensive care unit five tertiary hospitals China from March 1, 2021 December 31, 2021, were recruited. All subjects...
Reduced birth weight is associated with increased risk for the insulin resistance syndrome. Part of this hypothesized to originate from intrauterine growth retardation.The aim study determine whether or not components syndrome are reduced fetal growth.This was a case-control study.The conducted in Beijing, China.Included were 296 singleton neonates (177 males and 119 females), including 76 (37 preterm 39 full-term newborns) classified as small gestational age (SGA) 220 who appropriate (AGA)...
Background/Aims: Nasal continuous positive airway pressure (nCPAP) was recommended as the initial respiratory support for spontaneous breathing in infants with very low birth weight and neonatal distress syndrome (NRDS). Less invasive surfactant administration (LISA) minimally therapy (MIST) have been reported to reduce incidence of bronchopulmonary dysplasia (BPD). This study aimed explore applicability (MISA) China. Materials Methods: MISA a randomized controlled conducted at eight level...
To investigate the incidence of extrauterine growth retardation (EUGR) and its risk factors in very preterm infants (VPIs) during hospitalization China.A prospective multicenter study was performed on medical data 2 514 VPIs who were hospitalized department neonatology 28 hospitals from 7 areas China between September 2019 December 2020. According to presence or absence EUGR based evaluation body weight at corrected gestational age 36 weeks discharge, classified two groups: group (n=1 189)...
Abstract This retrospective cohort study aimed to investigate the prevalence, morbidity, mortality and maternal/neonatal care of preterm neonates perinatal risk factors for mortality. We included data on 13,701 born in 15 hospitals period 2013–2014 China. Results showed a prevalence 9.9%. Most infants at 24–27 weeks who survived more than 12 hours were mechanically ventilated (56.1%). Few before 28 received CPAP without first receiving mechanical ventilation (8.1%). antenatal steroid(35.8%...
Background: Globally, the proportion of child deaths that occur in neonatal period remains a high level 37–41%. Differences cause neonate death exist different regions as well economic development countries. The specific aim this study was to investigate causes, characteristics, and differences neonates during hospitalization tertiary Neonatal Intensive Care Unit (NICU) China. Methods: All dead admitted 26 NICUs were included between January l, 2011, December 31, 2011. data collected...
Children with vitamin A, D, and E deficiency are susceptible to respiratory infections. However, the correlations between levels Mycoplasma pneumoniae pneumonia (MPP) patient MPP occurrence is still unclear. This study aims measure compare serum in severe (sMPP) non-severe (nsMPP) investigate their of MPP.A total 122 children were enrolled, including 52 sMPP 70 nsMPP aged 0-15 years old 2015-2018. The vitamins measured compared, two-category logistic regression was used for correlation...
The management of enteral nutrition in very preterm infants (VPIs) is still controversial, and there no consensus on the optimal time point after birth at which can be started. aim this study was to investigate effect early initiation short-term clinical outcomes VPIs.Data (n = 2514) born before 32 wk gestation were collected from 28 hospitals located seven different regions China. Based whether feeding initiated within or 24 h since birth, divided into an (EIEF) group a delayed (DIEF)...
This single-center historical cohort study investigated the effectiveness and safety of extended infusion (EI) compared with short-term (STI) meropenem in neonatal sepsis. Patient electronic health records from Peking University Third Hospital (1 December 2011–1 April 2021) were screened. Neonates diagnosed sepsis treated intensive care unit included (256 patients) as STI (0.5 h, 129 EI (2–3 127 groups. Three-day clinical three-day microbial clearance considered main outcomes. Univariate...
The epidemiology and economic burden of hospitalized community-acquired pneumonia (CAP) children due to MP is still poorly understood. This study aimed investigate the dynamic changes Mycoplasma pneumoniae (MPP) in a general hospital.A total 2011 CAP aged 1-16 years at Peking University Third Hospital from 2017 2019 were enrolled by cross-sectional for retrospective analysis clinical data mainly including seasonal distribution MPP, hospital stay, severity, complications, use flexible...
Background: Extremely low birth weight (ELBW, &lt;1,000 g) infants have a high risk of metabolic bone disease (MBD). Because the late appearance radiological signs, diagnosis MBD in ELBW might be delayed, and its prevalence underestimated this group patients. This study adopted serial screening serum alkaline phosphatase (ALP) phosphate (P) to determine whether such is helpful for early detection MBD. Materials Methods: We performed retrospective preterm with gestational age ≤ 31 weeks...
The aim of this study was to investigate the effects soybean, medium-chain triacylglycerols (MCTs), olive oil, and fish oil (SMOF) on short-term clinical outcomes, physical growth, extrauterine growth retardation (EUGR) in very preterm infants.
Background Lactopontin (LPN) in breast milk, also known as milk osteopontin is thought to play a myriad of important roles infants when they are immature. The purpose the present study was examine longitudinal changes LPN concentrations term and preterm elucidate links between maternal characteristics, levels, child growth birth cohort. Methods 131 mothers who delivered term, moderate-late (MPT), very (VPT), extremely (EPT) were included, samples collected at 7, 14, 28, 120 days postpartum....
Sotos syndrome is an autosomal dominant genetic disorder caused by mutations in the NSD1 gene. In this study, we report a case of preterm infant. The main clinical manifestations were severe bronchopulmonary dysplasia, congenital heart disease, difficulty feeding, and characteristic facial appearance. gene mutation was located at 177251854 on chromosome 5, identified as shear mutation, c.4765+1 G > A, which new mutation. patient recovered well after symptomatic treatment. To best our...
Abstract Objective Nutritional deficiency soon after birth is a risk factor of chronic lung disease (bronchopulmonary dysplasia, BPD). Afflicted infants are further prone to inadequate growth during hospitalization (extrauterine restriction, EUGR). This multi-center retrospective study investigated factors EUGR, specifically in very preterm with BPD. Method Data BPD who were born less than 32 weeks gestation ( n = 1010) collected from 7 regions China. All non-small for gestational age at...