A5100785612- Thyroid Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Natural Products and Biological Research
- Growth Hormone and Insulin-like Growth Factors
- Antioxidant Activity and Oxidative Stress
- Insect and Pesticide Research
- Cholesterol and Lipid Metabolism
- Insect and Arachnid Ecology and Behavior
- Cancer, Hypoxia, and Metabolism
- Plant and animal studies
- Protein Tyrosine Phosphatases
- Chromatography in Natural Products
- Medicinal Plant Pharmacodynamics Research
- Protein Kinase Regulation and GTPase Signaling
- Vitamin C and Antioxidants Research
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Neuroendocrine regulation and behavior
- Liver Disease Diagnosis and Treatment
- S100 Proteins and Annexins
- Phytochemicals and Antioxidant Activities
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Xiangya Hospital Central South University
2025
Central South University
2025
Peking Union Medical College Hospital
2025
Shandong University
2018-2024
Jiangnan University
2013-2024
State Key Laboratory of Food Science and Technology
2015-2024
Shandong Provincial Hospital
2018-2024
Shandong First Medical University
2020-2024
Shandong Academy of Chinese Medicine
2018-2024
The antioxidant capacity of maca has been considered to be the basis for other bioactivities, and revealing active compounds would help elucidate a variety bioactive compounds. In this study, correlation between activity secondary metabolites, including ferric reducing potential (FRAP), hydroxyl radical scavenging ability (HRSA), lipid peroxidation inhibition (LPIA), total phenolic contents (TPCs), alkaloid (TACs), sterol (TSCs), was investigated by measuring. Chloroform selected an...
Oxidative stress is a crucial pathophysiological mechanism in chronic diseases and mortality. While individual oxidative markers have been studied, the comprehensive impact of balance on mortality risks remains unclear, particularly among cancer survivors. We aimed to investigate associations Balance Score (OBS) with both general population This study included 37,317 adults (52% female) from National Health Nutrition Examination Survey (2001-2018). OBS was calculated based antioxidant...
In mammals, leptin regulates food intake and energy balance mainly through the activation of LepRb in hypothalamus, estrogen has a leptin-like effect hypothalamic control metabolism. However, it remains to be elucidated how signaling is intertwined with pathway. We show here that Shp2, nonreceptor tyrosine phosphatase, acts integrate signals. The expression dominant-active mutant (Shp2(D61A)) forebrain neurons conferred female, but not male, transgenic mice resistance high-fat diet...
The molecular mechanism underlying adipogenesis and the physiological functions of adipose tissue are not fully understood. We describe here a unique mouse model severe lipodystrophy. Ablation Ptpn11/Shp2 in adipocytes, mediated by aP2-Cre , led to premature death, lack white fat, low blood pressure, compensatory erythrocytosis, hepatic steatosis Shp2 fat−/− mice. Fat transplantation partially rescued lifespan pressure mice, administration leptin also restored mutant animals with endogenous...
Subclinical hypothyroidism is associated with cardiovascular diseases, yet the underlying mechanism remains largely unknown. Herein, in a common population (n = 1,103), TSH level was found to be independently correlated both carotid plaque prevalence and intima-media thickness. Consistently, receptor ablation ApoE-/- mice attenuated atherogenesis, accompanied by decreased vascular inflammation macrophage burden atherosclerotic plaques. These results were also observed myeloid-specific...
Most research on neurodegenerative diseases has focused neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate contributions of to Huntington's disease (HD), we profiled gene expression alterations Drosophila expressing human mutant Huntingtin (mHTT) either or neurons compared changes what observed HD mice striata. A large portion conserved genes are concordantly dysregulated across three species; tested a high-throughput...
Phyllanthus emblica L. pomace is a waste residue obtained following juicing that contains many polyphenols. In this study, NKA-II resin was selected as the optimal macroporous for separation and employed to separate crude polyphenol extract of P. pomace. The conditions were optimized, content, components, antioxidant activity, potential anti-Alzheimer's effects measured before after purification. Results showed content purified 656.85 mg/g, which 2.1 times higher than nonpurified form....
Introduction: Impaired wound healing leads to compromised cutaneous barrier and dysfunction, which still remains a challenging problem. However, safe efficient materials treatments for promoting are lacking. Metal nanoparticles especially palladium (Pd NPs) have attracted tremendous interests in medical application recent years, due its unique physicochemical properties biological inertness. Thereinto, Pd icosahedra Icos octahedra Oct superior catalytic activity compared other shapes but the...
All-trans retinoic acid (ATRA), one of vitamin A derivatives, shows greater growth inhibition breast cancer cell for ER-positive than ER-negative cells, while triple negative such as MDA-MB-231 is poorly responsive to ATRA treatment. In this study, we found that combination ω-3 free fatty acids (ω-3 FFAs) and exhibited synergistic in three subtypes (ER
Alzheimer's disease (AD), an age-related neurodegenerative disorder and a serious public health concern, is mainly caused by β-amyloid (Aβ)-induced toxicity. Currently, limited number of drugs are effective against AD, only few used for its treatment. According to traditional Chinese medicine, white wax composed policosanol, hexacosanol, octacosanol. Policosanol has been shown reduce lipid levels in blood alleviate the symptoms associated with diabetic complications disorders, such as...
Breast cancer is a leading type of in women and generally classified into three subtypes ER+ /PR+ , HER2+ triple negative. Both omega-3 polyunsaturated fatty acids vitamin D3 play positive role the reduction breast incidence. However, whether combination has stronger protective effect on carcinogenesis still remains unknown. In this study, we show that ω-3 free (ω-3 FFAs) 1α, 25-dihydroxy-vitamin (VD3 ) dramatically enhances cell apoptosis among lines. Bcl-2 total PARP protein levels are...
Polymorphism and the ossification of ligaments deletion IVS20 or AA genotype A533C had an approximately 3 times greater chance not having than disease progression after surgery.We concluded that 4 SNPs analyzed appeared to have different effects on etiology pathology OPLL.To our knowledge, this study is first investigate relationship between these surgery.Our findings suggest presence specific genotypes IVS20-11delT may predict outcome surgical intervention.
Subclinical hyperthyroidism, a condition characterized by decreased thyroid-stimulating hormone (TSH) and normal concentration of thyroid hormone, is associated with an elevated risk for cognitive impairment. TSH the major endogenous ligand receptor (TSHR) its role dependent on signal transduction TSHR. It has not, however, been established whether TSHR signaling involved in regulation cognition. Here, we utilized Tshr knockout mice found that deletion led to significantly compromised...
Abstract Oxidative stress and inflammation contribute to hypertriglyceridemia‐induced nonalcoholic fatty liver disease (NAFLD). Cholesterol‐enriched diets increase the risk of NAFLD. Lycium ruthenium Murr. (LRM) contains water‐soluble antioxidant proanthocyanidins. Whether improves NAFLD remains elusive. In this study, we established a model NAFLD‐induced by cholesterol‐enriched high‐fat diet (western diet) in ApoE −/− mice; oxidative were examined intervened supplement extracts. LRM did not...
Retinoic acid (RA), is a promising therapeutic agent for the treatment of breast cancer. However, metabolic disorders and drug resistance reduce efficacy RA. In this study, we found that RA ω-3 polyunsaturated fatty acids (ω-3 PUFAs) synergistically induced cell death in vitro vivo autophagy activation. Moreover, RA-induced hypercholesterolemia was completely corrected by PUFA supplementation. addition, demonstrated effects combination on autophagic flux were independent two major canonic...
Rapamycin (Rp), the main mammalian target of rapamycin complex inhibitor, is a promising therapeutic agent for breast cancer. However, metabolic disorders and drug resistance reduce its efficacy. Epidemiological, clinical, experimental studies have demonstrated that omega-3 polyunsaturated fatty acids (ω-3 PUFAs) significantly incidence mortality cancer improve disorders.Three cell lines immunocompetent immunodeficient mice were used to evaluate effects Rp plus ω-3 PUFA treatment. The...