A5112100634- Multiple Myeloma Research and Treatments
- Nutritional Studies and Diet
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Chronic Lymphocytic Leukemia Research
- Iron Metabolism and Disorders
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Mobile Health and mHealth Applications
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- CAR-T cell therapy research
- Diet, Metabolism, and Disease
- Genetic Associations and Epidemiology
- Chronic Myeloid Leukemia Treatments
- Cell death mechanisms and regulation
- Nutrition, Genetics, and Disease
- Nutrition and Health in Aging
- RNA modifications and cancer
- Neurological Disease Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- Physical Activity and Health
- 3D Printing in Biomedical Research
- Cutaneous lymphoproliferative disorders research
Anhui Medical University
2009-2025
Second Hospital of Anhui Medical University
2009-2025
Zhejiang University
2015-2024
Second Affiliated Hospital of Zhejiang University
2008-2024
First Affiliated Hospital Zhejiang University
2012-2024
Liaoning University
2024
Ningxia Normal University
2024
Zhejiang Cancer Hospital
2022-2024
Air Force Medical University
2024
Sir Run Run Shaw Hospital
2023
To investigate ethnic difference in the associations of BMI with comorbidity, mortality, and body composition between mainland Chinese U.S. whites.Ethnic-comparison study using data from China Health Nutrition Survey, National Examination Zhejiang University (China) Columbia (U.S.).Chinese people experienced greater odds comorbidities than whites for a given after standardizing age sex: 43% diabetes, 30% dyslipidemia, 28% hypertension, 38% metabolic syndrome, 48% hyperuricemia. Comparisons...
Abstract Global germ line loss of fat mass- and obesity-associated ( FTO ) gene results in both the reduction mass lean mice. The role adipogenesis has been proposed, however, that myogenesis not. Skeletal muscle is main component body mass, so its connection with physiologic significance need to be clarified. Here, we assessed impact on murine skeletal differentiation by vitro vivo experiments. We found expression increased during myoblasts differentiation, while silence inhibited...
Abstract Targeted temperature management (TTM) is a vital intervention for cardiac arrest survivors to mitigate post-resuscitation myocardial dysfunction (PRMD). However, the optimal TTM remains topic of debate. This study investigates effects at different temperatures and explores underlying mechanisms using in vivo vitro models ischemia/reperfusion (I/R) injury following (CA) cardiopulmonary resuscitation (CPR). We found that 33 °C significantly improved hemodynamics function, reducing...
Abstract Metabolic syndrome (MetS), a cluster of metabolic disturbances that increase the risk for cardiovascular disease and diabetes, was because genetic susceptibility environmental factors. To identify variants associated with MetS components, we conducted genome‐wide association study followed by replications in totally 12,720 participants from north, north‐eastern eastern China. In combined analyses, independent top known signal at rs651821 on APOA 5, newly identified secondary...
High-fat diet (HFD)-induced obesity is a risk factor for many metabolic disorders including cardiovascular diseases, diabetes, and fatty liver disease. Although there are accumulating evidences supporting the assumption that regulating gut microbiota as well its status able to mitigate obesity, inner relationship between obesity-related relevant metabolites not defined. In current study, we applied traditional herbal formula Kang Shuai Lao Pian (KSLP) HFD-fed mice evaluated effect against...
Background: Recent studies have found that there are significant associations between body iron status and the development of diabetes. In present study, we aimed to analyze association among overload (IO), insulin resistance (IR), diabetes in Chinese adults, explore sex difference.Methods: Men women (age >19 years) who participated Health Nutrition Survey did not at baseline were followed 2009 2015 (n=5,779). Over a mean 6 years, 75 participants diagnosed with incident Logistic...
Objective The present study investigated the associations of body composition, including skeletal muscle and fat mass, with blood pressure (BP) hypertension. Methods Data from 3,130 participants aged 18 to 80 years were analyzed. Body composition total (TSM) measured or calculated based on dual‐energy x‐ray absorptiometry. Multivariate linear logistic regression models used analyze TSM, percentage, android gynoid ratio, leg arm lean mass (LBM) BP Wald test was estimate differences in...
Abstract Exercise can alter the composition of gut microbiota. However, studies examining effects exercise on microbiota in elderly are lacking. This study aims to investigate whether an 8-week training affect physically inactive women. Fourteen women were randomly assigned either group or control group. Repeated-measures analysis variance was used reveal changes Alpha diversity did not change significantly. A tendency form 2 clusters observed for operational taxonomic units (OTU) after...
Abstract Objective This study was to investigate the underlying mechanism by which Saikosaponin D (SSD) mitigates inflammatory response associated with osteoarthritis (OA) and regulates autophagy through upregulation of microRNA (miR)-199-3p downregulation transcription Factor-4 (TCF4). Methods A mouse OA model established. Mice were intragastrically administered SSD (0, 5, 10 μmol/L) or injected miR-199-3p antagomir into knee. Then, pathological changes in cartilage tissues observed. Normal...
Introduction Chinese are reported to have a higher percent body fat (%BF) and trunk (%TF) than whites for given mass index (BMI). However, the associations of these ethnic differences in composition with metabolic risks remain unknown. Methods Procedures A total 1 029 from Hangzhou, China, 207 New York, NY, USA, were recruited present study. Body was measured using dual-energy X-ray absorptiometry (DXA). Analysis covariance used assess fat, distribution, risk factors. Results After adjusting...
Background: The study was to investigate the prevalence of metabolic health in subjects with obesity Chinese population and identify determinants related abnormality obese individuals. Methods: 5013 were recruited from seven provincial capitals China. status classified based on body mass index (BMI) number abnormalities common components syndrome. Results: 27.9% individuals metabolically healthy. healthy (MHO) phenotype significantly decreased age women (p trend < 0.001), but not men =...
Abstract Human brucellosis is caused by Brucella species and remains a major burden in both human domesticated animal populations, especially Inner Mongolia, China. The aims of this study were to analyze the spatiotemporal trends Mongolia during 2010 2015, explore factors affecting incidence brucellosis. results showed that annual was 29.68–77.67 per 100,000, peaked from March June. majority male farmers herdsmen, aged 40–59 years. high-risk areas mainly Xilin Gol League Hulunbeier City....
To investigate the association of regional fat depots with metabolic risk factors in Chinese women.Total and including android gynoid were measured by dual-energy X-ray absorptiometry. Central distribution was defined as android:gynoid ratio. Metabolic elevated TAG, reduced HDL-cholesterol, blood pressure fasting plasma glucose. Logistic regression analyses performed to examine associations factors. The odds ratios risks further calculated according tertiles fat.Participants recruited from a...
The association of the rs9939609 single nucleotide polymorphism in FTO gene with obesity has been extensively investigated studies populations European, African, and Asian ancestry. However, inconsistent results have reported populations, relationship variation dietary behaviors only rarely examined Chinese children adolescents. aim this study was to assess preferences childhood a population. Epidemiological data including were collected interviews using survey questionnaires, genotype...
Abstract Aim Endothelial recovery, or re‐endothelialization, plays an important role in intimal hyperplasia and atherosclerosis after endothelial injury. Studying the mechanisms of re‐endothelialization strategies to promote efficient recovery are still needed. Interferon‐induced protein 35 ( IFI 35) is IFN ‐γ‐induced that roles antivirus‐related immune‐inflammatory response. In this study, we tested whether overexpression affects proliferation migration cells EC s) re‐endothelialization....
Background: Exercise can modulate gut microbiota and lower the risk of cardiovascular disease (CVD). However, association between exercise-induced changes in CVD have not been investigated. Objective: This study determined effects exercise training on physically active elderly women whether were associated with risk. Methods: An 8-week randomized controlled trial was conducted 14 assigned to group ( n = 8) or control 6). Physical function, sarcopenic obesity, metabolic syndrome evaluated as...