A5084435071- Intracranial Aneurysms: Treatment and Complications
- Spinal Fractures and Fixation Techniques
- Computational Drug Discovery Methods
- Antifungal resistance and susceptibility
- Cervical and Thoracic Myelopathy
- Fungal Infections and Studies
- Traditional Chinese Medicine Analysis
- Epilepsy research and treatment
- Plant-based Medicinal Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cerebrovascular and Carotid Artery Diseases
- Metabolomics and Mass Spectrometry Studies
- Plant Virus Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Statistical and Computational Modeling
- Environmental Toxicology and Ecotoxicology
- Immunotoxicology and immune responses
- Neurological disorders and treatments
- Plant Pathogens and Resistance
- Renal Transplantation Outcomes and Treatments
- Gut microbiota and health
- Animal testing and alternatives
- Pharmacological Effects and Toxicity Studies
- Probiotics and Fermented Foods
- Phytochemical Studies and Bioactivities
Shandong First Medical University
2020-2024
Shandong Provincial QianFoShan Hospital
2021-2024
First Affiliated Hospital of Zhengzhou University
2018-2021
Drug induced nephrotoxicity is a major clinical challenge, and it always associated with higher costs for the pharmaceutical industry due to detection during late stages of drug development. It desirable improving health outcomes patients distinguish nephrotoxic structures at an early stage In this study, we focused on in silico prediction insights into structural basis nephrotoxicity, based reliable data human nephrotoxicity. We collected 565 diverse chemical structures, including 287 drugs...
It has become a top global regulatory priority to prevent and control pollution from the release of synthetic chemicals, which continues affect aquatic communities. In past decades, computational tools were largely used significantly reduce budget time cost chemical acute toxicity assessment. But structural basis toxic compounds was rarely analyzed. present study, we collected 1438, 485 961 chemicals with data records for three representative species, including Tetrahymena pyriformis,...
The rapid and accurate evaluation of chemical toxicity is great significance for estimation safety. In the past decades, a number excellent computational models have been developed prediction. But most machine learning tend to be "black box", which bring about poor interpretability. present study, we focused on identification collection structural alerts (SAs) responsible series important endpoints. Then, carried out effective storage these web-server named SApredictor (www.sapredictor.cn)...
To establish a population pharmacokinetic (PopPK) model of posaconazole suspension in Chinese hematopoietic stem cell transplantation (HSCT) patients and to recommend an optimal dosing regimen. A single-center, retrospective, model-based study was conducted 62 patients, including 103 with plasma concentrations. PopPK analysis using NONMEM software. one-compartment first-order elimination absorption good agreement the experimental data. Analysis covariance showed that body weight (WT),...
The main characteristics of panic disorder (PD) include recurrent attacks and persistent worry, accompanied by other physical cognitive symptoms. While recent studies have revealed that gut bacteria play an important role in anxiety depression, little is known about the relationship between oral microbiota PD. Therefore, objective this study was to explore a possible correlation We conducted 16S rRNA sequencing compare differences patients with PD (n = 26) healthy controls 40). Patients...
Purpose: The drug-drug interactions (DDIs) of tacrolimus greatly contributed to pharmacokinetic variability. Nifedipine, frequently prescribed for hypertension, is a competitive CYP3A5 inhibitor which can inhibit metabolism. objective this study was investigate whether genotype could influence tacrolimus-nifedipine DDI in Chinese renal transplant patients. Method: All patients were divided into CYP3A5*3/*3 homozygotes (group I) and CYP3A5*1 allele carriers ( CYP3A5*1/*1 + CYP3A5*1/*3 ) II)....
Objectives The resistance of Candida albicans (C. albicans) to classical antifungals has been increasing significantly and poses great challenges clinical treatment. objective this research is evaluate whether the combination lonidamine (LND) fluconazole (FLC) have synergistic antifungal activity against C. explore underlying mechanisms FLC-resistant albicans.Methods effect on resistant planktonic preformed biofilms were performed by broth microdilution assay XTT reduction assay. influence...
The aim of the present study was to determine quality marker (Q-Markers) Sparganii Rhizoma against thrombus through an integration investigations on its antithrombotic effect, content determination and spectrum-effect correlation analysis.Based concept Q-Marker, investigated for identification chemical component. pharmacological effects arachidonic acid-induced thrombosis in zebrafish were also investigated. material basis ethanol extract determined by HPLC-UV. Furthermore, potential...
Abstract Objective: To identify the predictors of ischemic events secondary to cervicocerebral artery dissection (CAD). Methods: Consecutive patients with from 2010 2017 were registered as study subjects, who classified and without events. Clinical data collected prospectively, such demographics, vascular risk factors, headache neck pain, site laboratory test. A case-control was performed compare clinical between two groups. Results: total 130 included, in which 70.0% (91/130) suffered...
Abstract Objective : To identify the predictors of ischemic events secondary to cervicocerebral artery dissection (CAD). Methods Consecutive patients with from 2010 2017 were registered as study subjects, who classified and without events. Clinical data collected prospectively, such demographics, vascular risk factors, headache neck pain, site laboratory test. A case-control was performed compare clinical between two groups. Results total 130 included, in which 70.0% (91/130) suffered...
Objective: To compare and analyze the clinical features potential risk factors of intracranial extracranial arterial dissection. Methods: A total 241 consecutive patients with cervicocerebral artery dissection (CAD) in First Affiliated Hospital Zhengzhou University from 2010 to 2019 were observed. The CAD divided into group (EAD) (n=81) (IAD) (n=160), characteristics compared between two groups. Results: Compared EAD, National Institute Health Stroke Scale (NIHSS) score was higher ischemic...