A5030485878- Antifungal resistance and susceptibility
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Pneumocystis jirovecii pneumonia detection and treatment
- Traditional Chinese Medicine Analysis
- Fungal Infections and Studies
- Antibiotics Pharmacokinetics and Efficacy
Shandong Provincial QianFoShan Hospital
2022-2024
Shandong First Medical University
2022-2024
Background: Wendan Decoction (WDD) is a six-herb Chinese medicine recipe that was first mentioned in about 652 AD. It frequently used to treat hyperlipidemic patients’ clinical complaints. According reports, oxidative stress has significant role hyperlipidemia. Purpose: There not yet been thorough pharmacokinetic-pharmacodynamic (PK-PD) examination of the efficacy WDD context hyperlipemia-related stress. Therefore, goal this research explore antioxidant essence by developing PK-PD model,...
To establish a population pharmacokinetic (PopPK) model of posaconazole suspension in Chinese hematopoietic stem cell transplantation (HSCT) patients and to recommend an optimal dosing regimen. A single-center, retrospective, model-based study was conducted 62 patients, including 103 with plasma concentrations. PopPK analysis using NONMEM software. one-compartment first-order elimination absorption good agreement the experimental data. Analysis covariance showed that body weight (WT),...