A5085190525- Atherosclerosis and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Immune cells in cancer
- Nitric Oxide and Endothelin Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Eicosanoids and Hypertension Pharmacology
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- interferon and immune responses
- Cardiovascular Disease and Adiposity
- Diabetic Foot Ulcer Assessment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Artery Disease Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipose Tissue and Metabolism
- Tea Polyphenols and Effects
- Wound Healing and Treatments
South Australian Health and Medical Research Institute
2017-2025
The University of Adelaide
2007-2025
Australian Research Council
2019-2025
The University of Sydney
2013-2024
ARC Centre for Nanoscale BioPhotonics
2019-2024
Pfizer (United States)
2024
Novartis (Germany)
2024
Advanced Neural Dynamics (United States)
2023
University of South Australia
2022
The Heart Research Institute
2011-2022
Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs in proinflammatory environment. However, the role of inflammatory mediators fibrogenic responses is only poorly understood. We therefore investigated CC chemokines their receptors hepatic fibrogenesis. The MIP-1alpha, MIP-1beta, RANTES CCR1 CCR5 were strongly upregulated 2 experimental mouse models Neutralization by broad-spectrum chemokine inhibitor 35k efficiently reduced fibrosis, CCR1-...
Background Interleukin ( IL )‐1β, ‐18, and downstream ‐6 are key inflammatory cytokines in the pathogenesis of coronary artery disease. Colchicine is believed to block NLRP 3 inflammasome, a cytosolic complex responsible for production ‐1β ‐18. In vivo effects colchicine on cardiac cytokine release have not been previously studied. This study aimed (1) assess local patients with acute syndromes ACS ), stable disease controls; (2) determine whether administration inhibits their production....
Objective— Microparticles of iron oxide (MPIO) distort magnetic field creating marked contrast effects far exceeding their physical size. We hypothesized that antibody-conjugated MPIO would enable resonance imaging (MRI) endothelial cell adhesion molecules in mouse atherosclerosis. Methods and Results— (4.5 μm) were conjugated to monoclonal antibodies against vascular molecule-1 (VCAM–MPIO) or P-selectin (P-selectin–MPIO). In vitro, VCAM–MPIO bound, dose-dependent manner, tumor necrosis...
Wound healing and repair are the most complex biological processes that occur in human life. After injury, multiple pathways become activated. Impaired wound healing, which occurs diabetic patients for example, can lead to severe unfavorable outcomes such as amputation. There is, therefore, an increasing impetus develop novel agents promote repair. The testing of these has been limited large animal models swine, often impractical. Mice represent ideal preclinical model, they economical...
Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis-associated inflammation. This study aims to assess acute coronary syndrome (ACS) patients (1) inflammasome activation circulating monocytes (2) whether short-term oral colchicine, a recognized anti-inflammatory agent that shown be cardio-protective clinical studies, might acutely suppress inflammasome-dependent ACS (n=21) were...
To investigate whether high-density lipoproteins (HDLs) suppress chemokine (CCL2, CCL5, and CX(3)CL1) receptor (CCR2 CX(3)CR1) expression, a mechanism for the atheroprotective properties of HDLs.Apolipoprotein (apo) E(-/-) mice were fed high-fat diet 12 weeks. Before being euthanized, received 5 consecutive daily injections lipid-free apoA-I, 40 mg/kg, or saline (control). The injection apoA-I reduced CCR2 CX(3)CR1 expression in plaques compared with controls (P<0.05). ApoA-I-injected had...
Abstract Preclinical and clinical diagnostics increasingly rely on techniques to visualize internal organs at high resolution via endoscopes. Miniaturized endoscopic probes are necessary for imaging small luminal or delicate without causing trauma tissue. However, current fabrication methods limit the performance of highly miniaturized probes, restricting their widespread application. To overcome this limitation, we developed a novel ultrathin probe technique that utilizes 3D microprinting...
Next generation wound care technology capable of diagnosing parameters, promoting healthy cell growth, and reducing pathogenic infections noninvasively would provide patients with an improved standard accelerated repair. Temperature is one the indicating biomarkers specific to chronic wounds. This work reports a hybrid, multifunctional optical material platform—nanodiamond (ND)–silk membranes as biopolymer dressings temperature sensing healing. The hybrid structure was fabricated through...
Abstract Multimodal microendoscopes enable co‐located structural and molecular measurements in vivo, thus providing useful insights into the pathological changes associated with disease. However, different optical imaging modalities often have conflicting requirements for optimal lens design. For example, a high numerical aperture (NA) is needed to realize high‐sensitivity fluorescence measurements. In contrast, coherence tomography (OCT) demands low NA achieve large depth of focus. These...
Abstract Colchicine is a broad‐acting anti‐inflammatory agent that has attracted interest for repurposing in atherosclerotic cardiovascular disease. Here, we studied its ability at human equivalent dose of 0.5 mg/day to modify plaque formation and composition murine atherosclerosis investigated actions on macrophage responses atherogenic stimuli vitro. In induced by high‐cholesterol diet, Apoe −/− mice treated with colchicine had 50% reduction aortic oil Red O + area compared saline control...
Chemokines are important mediators of inflammatory cell recruitment that play a significant role in atherosclerosis. Fractalkine (CX3CL1) is an unusual membrane-bound chemokine mediates chemotaxis through the CX3CR1 receptor. Recently, functional polymorphisms human gene have been described associated with coronary artery disease.We investigated expression CX3C fractalkine and its receptor plaques by immunocytometry. We show subset mononuclear cells expresses high levels atherosclerotic...
Chronic wounds are a major complication in patients with cardiovascular diseases. Cell therapies have shown potential to stimulate wound healing, but clinical trials using adult stem cells been tempered by limited numbers of and invasive procurement procedures. Induced pluripotent (iPSCs) several advantages other cell types, for example they can be generated abundance from patients’ somatic (autologous) or those matched donor. iPSCs efficiently differentiated functional endothelial...