A5016929338- Coronary Interventions and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Optical Coherence Tomography Applications
- Bone Tissue Engineering Materials
- Angiogenesis and VEGF in Cancer
- Nitric Oxide and Endothelin Effects
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Biomarkers in Disease Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Osteoarthritis Treatment and Mechanisms
- Peripheral Artery Disease Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Cardiac Ischemia and Reperfusion
The University of Adelaide
2023-2025
The University of Sydney
2023
Objective: In-stent neoatherosclerosis is a phenomenon of percutaneous coronary intervention with stenting. Whilst similar to de novo atherosclerosis, it develops rapidly over 1-5 years rather than lifetime. No preclinical small animal models exist that allow full elucidation biology and future treatments. The aim this study was establish validate novel murine model in-stent neoatherosclerosis. Approach Results: Murine stainless-steel stents (2.5 x 0.7 mm) were deployed into donor descending...
Pyruvate improves cellular and organ function during hypoxia ischemia stabilizes the NADH redox state cytosolic ATP phosphorylation potential. In this in vivo study, we evaluated effects of intravenous pyruvate on cardiovascular neocortical function, indexes (lactate/pyruvate ratio, L/P) energy (adenosine degradative products hypoxanthine inosine, ADO + HX Ino) controlled arterial hemorrhage (40 mmHg) sedated swine (45 kg). Na was infused 1 h before (1 g ⋅ kg −1 ) 2 (0.5 to attain levels 6...
Abstract Atherosclerosis is the build-up of fatty plaques within blood vessel walls, which can occlude vessels and cause strokes or heart attacks. It gives rise to both structural biomolecular changes in walls. Current single-modality imaging techniques each measure one these two aspects but fail provide insight into combined changes. To address this, our team has developed a dual-modality system combines optical coherence tomography (OCT) fluorescence that optimized for porphyrin lipid...
Atherosclerosis is characterised by the buildup of plaque in inner lining vessels. Unstable atherosclerotic plaques are prone to rupture, which can lead heart attacks or strokes. Current clinically available imaging techniques cannot accurately identify unstable based on their structural features. It has been previously reported that may emit autofluorescence. Therefore, our team developed a dual modality optical coherence tomography and fluorescence intravascular system, miniaturised...
A fundamental challenge in endoscopy is how to fabricate a small fiber-optic probe that can achieve comparable function probes with large, complicated optics (e.g., high resolution and extended depth of focus). To over an focus (DOF), the application needle-like beams has been proposed. However, existing methods using miniaturized needle beam designs fail adequately correct astigmatism other monochromatic aberrations, limiting at least one axis. Here, we describe novel approach realize...