A5040913577- Diamond and Carbon-based Materials Research
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticles: synthesis and applications
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Ionic liquids properties and applications
- Crystallization and Solubility Studies
- Polymer Surface Interaction Studies
- Polymer Nanocomposite Synthesis and Irradiation
- Molecular Sensors and Ion Detection
- Crystallography and molecular interactions
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Nonlinear Optical Materials Studies
- Luminescence and Fluorescent Materials
- Protein Interaction Studies and Fluorescence Analysis
- Magnesium Alloys: Properties and Applications
- Enzyme-mediated dye degradation
- Advanced Cellulose Research Studies
- Laser Material Processing Techniques
- Analytical chemistry methods development
- Advanced X-ray and CT Imaging
- Analytical Chemistry and Sensors
- Laser Applications in Dentistry and Medicine
RMIT University
2014-2024
Australian Research Council
2020
MIT University
2014
The toxicity of manufactured nanoparticles varies greatly depending on the test species in consideration and estimates may also be confounded by media which organisms are cultured. For a more comprehensive evaluation, at different trophic levels or with life strategies, tested should included. In this study, we examined tyrosine-coated silver nanonparticles (tyr-AgNP) to three Australian freshwater invertebrates: Hydra vulgaris, Daphnia carinata Paratya australiensis. Tyr-AgNPs were...
Next generation wound care technology capable of diagnosing parameters, promoting healthy cell growth, and reducing pathogenic infections noninvasively would provide patients with an improved standard accelerated repair. Temperature is one the indicating biomarkers specific to chronic wounds. This work reports a hybrid, multifunctional optical material platform—nanodiamond (ND)–silk membranes as biopolymer dressings temperature sensing healing. The hybrid structure was fabricated through...
Fluorescent nanoparticles (NPs) have been increasingly studied as contrast agents for better understanding of biological processes at the cellular and molecular level. However, their use bioimaging tools is strongly dependent on optical emission well biocompatibility. This work reports fabrication characterization silk fibroin (SF) coated magnesium oxide (MgO) nanospheres, containing oxygen, Cr3+ V2+ related defects, a nontoxic biodegradable hybrid platform applications. The MgO-SF spheres...
A pyridyl functionalised tetraphenylethylene (Py-TPE) for ratiometric fluorescent detection of intracellular pH values is reported; the Py-TPE probe can be used H<sup>+</sup> sensing in organic solvents (CHCl<sub>3</sub>, DMF and MeOH).
Imaging of biological matter by using fluorescent nanoparticles (NPs) is becoming a widespread method for in vitro imaging. However, currently there no NP that satisfies all necessary criteria short-term vivo imaging: biocompatibility, biodegradability, photostability, suitable wavelengths absorbance and fluorescence differ from tissue auto-fluorescence, near infrared (NIR) emission. In this paper, we report on the photoluminescent properties magnesium oxide (MgO) NPs meet these criteria....
The rapid formation of the protein corona on to nanoparticle (NP) surface is key that confers biological identity NPs and subsequently dictates their fate both in vitro vivo. Despite significant efforts, inability control spontaneous interaction serum proteins with administered remains a major constraint clinical translation nanomedicines. ligands present NP offer promise controlling interactions; however, influence NP-protein not well-understood. current study investigates potential...
Ionic liquids (ILs) are a diverse class of solvents which can be selected for task-specific properties, making them attractive alternatives to traditional solvents. To tailor ILs specific biological applications, it is necessary understand the structure–property relationships and their interactions with cells. Here, selection carboxylate anion-based were investigated as cryoprotectants, compounds added cells before freezing mitigate lethal damage. The cytotoxicity, cell permeability, thermal...
Magnesium (Mg) and its alloys are promising biodegradable metallic implant materials. However, their clinical applications limited by fast corrosion rate in the biological environment. In this work, with an outlook to improve vitro resistance of Mg WE43 alloy, a layer-by-layer interfacially engineered anticorrosive bioactive coating consisting natural oxide lower layer, hydroxyapatite (HA) middle silk fibroin (SF) top layer was fabricated investigated. Anodization used create induced...
Abstract Zinc oxide (ZnO) is a promising semiconductor that suitable for bioimaging applications due to its intrinsic defect fluorescence. However, ZnO generally suffers from poor photostability. We report room-temperature single-photon emission optical defects found in nanoparticles (NPs) formed by ion implantation followed thermal oxidation silica substrate. conduct thorough investigation into the photophysics of particularly bright and identify other single emitters within NPs....
Nanocellulose has emerged as a promising material for many biomedical applications. Depending on the source of nanocellulose and chemical treatment, resulting optical properties can vary significantly. In particular, autofluorescence exist in various wavelength ranges. Except chlorophyll related autofluorescence, all other studies have reported intrinsic fluorescence blue to yellow range. However, this range coincides with cells. Here, we report cell friendly red fibers fiber-derived...
The development of functional materials is a crucial step in the newer and better technologies. efficient luminescent materials, whose potential lie applications fields such as electronics, optics, data storage, biological sciences, through simple synthetic procedures therefore interest. Herein, we report synthesis tetrapyridinium-tetraphenylethylene (TPy-TPE) luminogen with multiple functionalities. TPy-TPE displayed characteristic features an aggregation-induced emission material being...
Abstract The flavone ligands 8‐chloro‐2‐tetrahydrofuryl‐1,4‐benzopyrone and 8‐chloro‐2‐(2‐methyltetrahydrofuryl)‐1,4‐benzopyrone have been used to prepare the first examples of alkynyl phosphine gold compounds containing flavonoids which exhibit cytotoxicity towards human prostate cancer cells.
The surface of an orthopaedic implant plays a crucial role in determining the adsorption proteins and cell functions. A detailed comparative study has been made vitro osteoblast responses to coarse-grained (grain size: 500 μm), ultrafine-grained 100 nm), coarse-porous (pore 350 fine-porous 155 nm) surfaces Ti-20Mo alloy. purpose was provide essential experimental data for future design titanium implants rapid osseointegration. Systematic original produced each type terms wettability,...
Statistical data have consistently shown that implant loosening is a significant causative factor for revision surgeries. Both in vivo and vitro studies confirmed the positive influences of microgrooved titanium surfaces on improving orthopedic implants compared with smooth surface. Complete cell-groove adhesion prerequisite rapid robust osseointegration. For first time, this work has quantified influence groove width at subcellular scale (5-20 μm) osteoblast responses, using titanium-coated...
Metal–organic frameworks (MOFs) are extensively studied materials for delivering a wide range of therapeutic entities including nucleic acids. Protein corona from serum may change biological identity and properties these biocomposites.
Abstract Multimodal imaging promises to revolutionize the understanding of biological processes across scales in space and time by combining strengths multiple techniques. Fluorescent nanodiamonds (FNDs) are biocompatible, chemically inert, provide high contrast light‐ electron‐based microscopy, versatile optical quantum sensors. Here it is demonstrated that FNDs also absorption nanoscale 3D soft X‐ray tomograms with a resolution 28 nm all dimensions. Confocal fluorescence, atomic force,...
Deep eutectic solvents (DESs) and ionic liquids (ILs) are highly tailorable that have shown a lot of promise for variety applications including cryopreservation, drug delivery, protein stabilisation. However, to date, there is very limited information on the detailed interactions these with mammalian cells. In this work, we studied six DESs one IL show as cryoprotective agents, applying synchrotron macro–ATR–FTIR examine their effects key biochemical components HaCat These data were paired...
Abstract Fluorescent nanodiamonds (FNDs) containing quantum defects enable the optical measurement of electromagnetic fields and temperature are among most developed nanoscale sensors today. Yet, for many applications in biomedicine beyond, FNDs must be integrated into biocompatible substrates that preserve FND sensitivity bring within distance their sensing target. At same time, high excitation light intensity required protocols remains a major challenge biomedicine. Here, it is shown...
Photoluminescent defects in diamond, like the nitrogen-vacancy (NV) color center, are at forefront of emerging optical quantum technologies. Most emit visible and near-infrared spectral region below 1000 nm (NIR-I), limiting their applications photonics, fiber communications, biology. Here, we show that nitrogen-vacancy-nitrogen ($N_2V$) which emits near-infrared-II (NIR-II, 1000-1700 nm), is ubiquitous as-synthesized processed nitrogen-doped diamond from bulk samples to nanoparticles. We...
Modern functional foods are designed to provide health benefits beyond basic nutrition. They enriched with bioactive ingredients like probiotics, vitamins, minerals, and antioxidants. These support overall health, enhance immune function, help prevent chronic diseases. Milk proteins tea known influence satiety regulate body weight. Studies have shown that green polyphenols, namely, (−)-epigallocatechin gallate (EGCG), whey proteins, predominantly lactoferrin (LF) from milk, play a role in...
The ability to form diamond electrodes on insulating polycrystalline substrates using single-step laser patterning, and the use of as a substrate that supports adhesion proliferation human mesenchymal stem cells (hMSCs) is demonstrated. Laser induced graphitisation results in conductive amorphous carbon surface, rich oxygen nitrogen terminations. This an electrode with high specific capacitance 182 uF/cm2, wide water window 3.25 V, low electrochemical impedance 129 Ohms/cm2 at 1 kHz. surface...