A5021212974- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Oxidative Organic Chemistry Reactions
- Synthesis and Characterization of Pyrroles
- Crystallography and molecular interactions
- Analytical Chemistry and Sensors
- Peptidase Inhibition and Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Molecular Sensors and Ion Detection
- Synthesis and Biological Evaluation
- Metal-Organic Frameworks: Synthesis and Applications
- Pneumonia and Respiratory Infections
- Biosensors and Analytical Detection
- Antibiotic Resistance in Bacteria
- Asymmetric Synthesis and Catalysis
- Bacterial biofilms and quorum sensing
- Dyeing and Modifying Textile Fibers
- Bacterial Identification and Susceptibility Testing
- Analytical chemistry methods development
- Bacterial Infections and Vaccines
- Cyclopropane Reaction Mechanisms
- Medicinal Plants and Neuroprotection
- Click Chemistry and Applications
- Vanadium and Halogenation Chemistry
- Cholinesterase and Neurodegenerative Diseases
RMIT University
2019-2023
University of Sunderland
2012-2020
The University of Sydney
2014-2019
CSIRO Manufacturing
2017-2019
Clayton Foundation
2019
Commonwealth Scientific and Industrial Research Organisation
2018
Cooperative Trials Group for Neuro-Oncology
2016
Budapest University of Technology and Economics
2010
First Technical University
2007
Abstract Despite their impressive optical properties, lead halide perovskite quantum dots (PQDs) have not realized potential, especially in bioimaging applications, as they suffer from poor moisture and thermal stability, solvent incompatibility, significant toxicity. Here, a spray‐assisted coil–globule transition method for encapsulating CsPbBr 3 (CPB) PQDs into poly(methyl methacrylate) (PMMA) polymer nanospheres is reported. Polyvinylpyrrolidone‐capped CPB are synthesized via the ligand...
The ursane triterpenoids, asiatic acid 1 and madecassic 2, are the major pharmacological constituents of Centella asiatica, commonly known as Gotu Kola, which is used traditionally for treatment anxiety improvement cognition memory. Using two-electrode voltage-clamp technique, these triterpenes, some semisynthetic derivatives, were found to exhibit selective negative modulation different subtypes GABAA receptor expressed in Xenopus laevis oocytes. Despite differing by only one hydroxyl...
Experimental and theoretical charge density of piroxicam, saccharin their 1 : co-crystal have been determined using high-resolution X-ray diffraction, multipole refinement DFT calculations
Metal–organic frameworks (MOFs) are extensively studied materials for delivering a wide range of therapeutic entities including nucleic acids. Protein corona from serum may change biological identity and properties these biocomposites.
Several novel fluorogenic N-aminoacylnaphthyridine substrates were synthesized in good yield and tested for their ability to detect pathogenic bacteria agar-based cell culture. Simple 2-N-(β-alanyl)amino-5,7-dialkylnaphthyridine selectively hydrolysed by β-alanylaminopeptidase expressing bacteria, but subject diffusion the agar medium. Diffusion was reduced 2-N-(β-alanyl)amino-7-alkylnaphthyridine with longer alkyl chains, inhibition of growth increased....
Experimental charge density distribution studies of two polymorphic forms piroxicam, β-piroxicam (1) and piroxicam monohydrate (2), were carried out via high-resolution single crystal X-ray diffraction experiments multipole refinement. The asymmetric unit (2) consists discrete molecules, (2a) (2b), water molecules. Geometry differs between due to the zwitterionic nature which results in rotation pyridine ring around C(10)-N(2) bond by approximately 180°. Consequently, amide are no longer...
Novel Griess reagents were identified using molecular fingerprint searching and rapid experimental evaluation for the detection of nitrite in aqueous media.
Given the increase in resistance to antibacterial agents, there is an urgent need for development of new agents with novel modes action. As interim solution, it also prudent reinvestigate old or abandoned compounds assess their efficacy context widespread conventional agents. In 1970s, much work was performed on peptide mimetics, exemplified by phosphonopeptide, alafosfalin. We investigated activity alafosfalin, di-alanyl fosfalin and β-chloro-L-alanyl-β-chloro-L-alanine against 297...
The charge density distribution in 2,2′-dihydroxy-1,1′-naphthalazine (Pigment Yellow 101; P.Y.101) has been determined using high-resolution X-ray diffraction and multipole refinement, along with functional theory calculations.
The fluorogenic self-immolative substrates<bold>8</bold>are specifically hydrolyzed by β-alanyl aminopeptidase, resulting in a 1,6-elimination and the release of highly fluorescent hydroxycoumarins<bold>6</bold>.
New fluorogenic enzyme substrates were synthesized by the coupling of aminonaphthalenesulfonamides or 6-hydrazinobenz[de]isoquinoline-1,3-diones with β-alanine. The also condensed a range aryl aldehydes to give corresponding hydrazones. photophysical properties amines and hydrazines their amide, hydrazide hydrazone derivatives, examined they incorporated into Columbia agar in order determine potential for detection pathogenic bacteria.
Paracetamol (PCM) has two well-documented polymorphic forms at room temperature; monoclinic Form I is more stable than the other orthorhombic II. II exhibits improved tabletting properties compared to due low shearing forces; however, difficulties in its manufacture have limited use industrial manufacture. Previous studies found that introduction of a co-former form co-crystals would allow PCM molecule exist conformation similar while being temperature. Experimental charge density analysis...
A series of fluorescent coumarin derivatives 2a-e were systematically designed, synthesized and studied for their Cu2+ sensing performance in aqueous media. The sensitivities selectivities the on-to-off signal direct correlation with relative arrangements heteroatoms within coordinating moieties these coumarins. Probes 2b 2d exhibited concentration dependent selective fluorescence quenching, linear ranges 0-80 μM 0-10 μM, limits detection 0.14 0.38 respectively. Structural changes upon...
A new method for converting 1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolines into 5,6-dihydropyrrolo[2,1-a]isoquinolines using N-bromosuccinimide as an oxidant is presented.
A new method for converting 1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolines into 5,6-dihydropyrrolo[2,1-a]isoquinolines by the use of N-bromosuccinimide as an oxidant is presented.
Selective detection of β-alanyl aminopeptidase (BAP)-producing Pseudomonas aeruginosa, Serratia marcescens, and Burkholderia cepacia was achieved by employing the blue-to-yellow fluorescent transition a BAP-specific enzyme substrate, 3-hydroxy-2-(p-dimethylaminophenyl)flavone derivative, incorporating self-immolative linker to β-alanine. Upon cellular uptake accumulation substrate viable bacterial colonies, blue fluorescence generated, while hydrolysis N-terminal peptide bond BAP resulted in...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access Abstract, please click on HTML or PDF.