A5101723295- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Wnt/β-catenin signaling in development and cancer
- Amino Acid Enzymes and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- RNA modifications and cancer
- Advanced Glycation End Products research
- Polyamine Metabolism and Applications
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Ginseng Biological Effects and Applications
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Antioxidants, Aging, Portulaca oleracea
- Pain Mechanisms and Treatments
- Genetic Syndromes and Imprinting
- Receptor Mechanisms and Signaling
Chongqing Medical University
2019-2025
Fudan University
2020-2024
State Key Laboratory of Medical Neurobiology
2020-2024
Henan University
2024
Wuhan General Hospital of Guangzhou
2024
Fujian Agriculture and Forestry University
2023
Guangzhou University
2022
Wuhan University of Science and Technology
2016-2021
South China Agricultural University
2021
Southwest University
2021
Background & Aims Accumulating research has addressed the linkage between changes to gut microbiota structure and type 2 diabetes (T2D). Inulin is one of soluble dietary fiber that can alleviate T2D. As a prebiotic, inulin cannot be digested by humans, but rather probiotics. However, whether treatment benefit entire bacteria community remains unknown. In this study, we evaluated differences in composition among diabetic, inulin-treated normal control, control rats. Methods A diabetic rat...
Aim Glycyrrhizin (GL) has been reported to protect against ischemia and reperfusion (I/R)-induced injury by inhibiting the cytokine activity of high mobility group box 1 (HMGB1). In present study, protective effects GL I/R injury, as well related molecular mechanisms, were investigated in rat brains. Methods Focal cerebral was induced intraluminal filamentous occlusion middle artery (MCA) Male Sprague-Dawley rats. alone or rHMGB1 administered intravenously at time reperfusion. Serum levels...
Breast cancer is the second leading cause of death among females. We sought to identify microRNA (miRNA) markers in breast cancer, and determine whether miRNA expression predictive early stage cancer. The paired panel microRNAs promising.
Oxidative stress induced by chemotherapeutic agents causes hepatotoxicity. 5-Fluorouracil (5-FU) has been found to have a variety of side effects, but its toxic effect on the liver and mechanism are still unclear. Angelica polysaccharide (ASP), main active ingredient Dang Gui, antioxidative effects. In this study, we investigated antagonistic effects ASP 5-FU-induced injury in mouse human normal cell line MIHA possible mechanism. Our results show that inhibited decrease Bcl-2 protein...
Chronic kidney disease (CKD) is problem that has become one of the major issues affecting public health. Extensive clinical data suggests prevalence hyperlipidemia in CKD patients significantly higher than general population. Lipid metabolism disorders can damage renal parenchyma and promote occurrence cardiovascular (CVD). Cyanate a uremic toxin attracted widespread attention recent years. Usually, 0.8% molar concentration urea converted into cyanate, while myeloperoxidase (MPO) catalyzes...
Background: Neural stem cells (NSCs) disrupt with aging, contributing to neurodegeneration. Ginsenoside Rg1 (Rg1), a compound found in Ginseng, is known for its anti-aging effects; however, role the progression of aging NSCs remains unclear. Therefore, this investigation explored impact on growth and maturation NSC elucidated underlying molecular mechanisms. Methods: Initially, mouse models brain were successfully established using D-galactose (D-gal) injection. Mice received treatment along...
Abstract Genome-wide association studies uncovered the of ZNF804A (Zinc-finger protein 804A) with schizophrenia (SZ). In vitro data have indicated that might exert its biological roles by regulating spine and neurite morphogenesis. However, no in vivo are available for role psychiatric disorders general, SZ particular. We generated ZFP804A mutant mice, they showed deficits contextual fear spatial memory. also observed sensorimotor gating impairment, as revealed prepulse inhibition test, but...
The urea cycle (UC) removes the excess nitrogen and ammonia generated by nitrogen-containing compound composites or protein breakdown in human body. Research has shown that changes UC enzymes are not only related to tumorigenesis tumor development but also associated with poor survival hepatocellular, breast, colorectal cancers (CRC), etc. Cytoplasmic ornithine, intermediate product of cycle, is a specific substrate for ornithine decarboxylase (ODC, known as ODC1) production putrescine...
Longer-term deterioration in saliva secretion has been observed to occur response aging. The functional of the salivary gland damages swallowing and chewing abilities consequently reduces life quality elderly. There are, however, only a few proven effective treatments for aging disorders. Ganoderma lucidum polysaccharide (GLP) applied treat various diseases because its safety, efficacy, low cost. We investigated protective effect GLP on submandibular (SMG) during D-galactose (D-gal) was used...
Angelica Sinensis polysaccharide (ASP), the main active component of sinensis, possesses antioxidative and anti-apoptotic properties. In this study, we have investigated antagonistic effect ASP on 5-FU-induced injury mouse spleen in vivo splenocytes vitro, its possible mechanism. Our results showed that inhibited decreases weight organ index mice, restored number peripheral blood leukocytes lymphocytes, repaired structure disorder functional impairment, rescued serum IL-2, IL-6, IFN-γ...
Accumulation of amyloid β-peptide (Aβ) is implicated in the pathogenesis and development Alzheimer's disease (AD). Neuron-enriched miRNA was aberrantly regulated may be associated with AD. However, regarding whether involved accumulation Aβ AD, underlying molecule mechanism remains unclear. Therefore, we conduct a systematic identification promising role miRNAs deposition, shed light on molecular target SH-SY5Y cells treated Aβ-induced cytotoxicity. Statistical analyses microarray data...
Yiqi Huoxue Recipe (YHR) is commonly used in China to treat diseases such as heart failure (HF). It has been reported that YHR can HF and a certain protective effect on myocardial cell damage. The purpose of this study determine the cardioprotective effects HF-induced apoptosis clarify its mechanism action. Oxygen glucose deprivation/recovery (OGD/R) induces H9C2 model. Ligation left anterior descending artery (LAD) coronary induce an animal model HF. We found protected cells from...
Evodiamine (Evo), a quinazoline alkaloid and one of the most typical polycyclic heterocycles, is mainly isolated from Evodia rugulosa . Vasculogenic mimicry (VM) newly identified way angiogenesis during tumor neovascularization, which prevalent in variety highly invasive tumors. The purpose this study was to investigate effect mechanism Evo on VM human colorectal cancer (CRC) cells. number structures calculated by three-dimensional culture CRC Wound-healing used detect migration HCT116 Gene...
Liver cancer presents divergent clinical behaviors. There remain opportunities for molecular markers to improve liver diagnosis and prognosis, especially since tRNA-derived small RNAs (tsRNA) have rarely been studied. In this study, a random forests (RF) diagnostic model was built based upon tsRNA profiling of paired tumor adjacent normal samples validated by independent validation (IV). A LASSO used developed seven-tsRNA-based risk score signature prognosis. Model performance evaluated...
B-lymphocytopenia among myelosuppression is the most intractable side effect of chemotherapy. Here, we investigated ways to alleviate 5-fluorouracil-caused stress hematopoietic impairment. We found that intraperitoneally injected ASP (Angelica sinensis polysaccharides) (100 mg/kg per day), one main active ingredient Angelica sinensis, for consecutive 7 days, significantly recovered mouse bone marrow pro-B and pre-B cells, reversed capacity CFU-PreB colony forming, thus alleviating B cell...
The cerebellum is responsible for coordinating motor functions and has a unique laminated architecture. Purkinje cells are inhibitory neurons represent the only output from cerebellar cortex. Tyrosine hydroxylase (TH) key enzyme synthesis of catecholamines, including dopamine noradrenaline, it normally not expressed in neurons. We report here that low-density lipoprotein receptors (Lrp) 5 6, Wnt co-receptors, required development suppressing ectopic TH expression cells. Simultaneous...
The canonical Wnt signaling pathway is critical for the development of midbrain dopaminergic (DA) neurons, and recent studies have suggested that disruption this cascade may underlie pathogenesis Parkinson's disease (PD). However, exact role pathway, including low‑density lipoprotein receptor‑related protein 5 6 (LRP5/6) β‑catenin components, in a mouse model PD remains unclear. In present study, tyrosine hydroxylase (TH)‑Cre transgenic line was used to generate mice with specific knockout...
<b><i>Objective:</i></b> To investigate the therapeutic effect of carbon monoxide (CO) on high-altitude hypoxia-induced cardiac damage. <b><i>Methods:</i></b> Forty male C57BL/6 mice were randomly divided into 4 groups. The exposed to normoxia or simulated 5,500-meter hypoxia in a hypobaric chamber for 7 days. During first 3 days, pretreated with CO-saturated hemoglobin (Hb)-based oxygen carrier (CO-HBOC), oxygen-saturated hemoglobin-based...