A5038715047- HIV-related health complications and treatments
- HIV Research and Treatment
- Extracellular vesicles in disease
- HIV/AIDS Research and Interventions
- Tryptophan and brain disorders
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Piperaceae Chemical and Biological Studies
- LGBTQ Health, Identity, and Policy
- Cytomegalovirus and herpesvirus research
- Reproductive System and Pregnancy
- Adolescent Sexual and Reproductive Health
- Gene expression and cancer classification
- Mitochondrial Function and Pathology
- Traditional and Medicinal Uses of Annonaceae
- vaccines and immunoinformatics approaches
- Inflammasome and immune disorders
Cornell University
2021-2024
Weill Cornell Medicine
2021-2024
Kuakini Medical Center
2021
University of Hawaiʻi at Mānoa
2019-2021
University of Hawaii System
2019-2021
Honolulu University
2020
Mount Sinai Hospital
2017
University of Toronto
1988
Background Neurocognitive impairment remains prevalent in people with HIV (PWH) despite long term virological suppression by antiretroviral therapy (ART) regimens. Systemic and neuro-inflammatory processes are suggested to contribute the complex pathology leading cognitive this population, yet underlying mechanisms remain unresolved. Extracellular vesicles (EVs) play a central role intracellular communication have emerged as key modulators of immunological inflammatory responses. In report,...
Since the onset of COVID-19 pandemic, increasing cases with variable outcomes continue globally because variants and despite vaccines therapies. There is a need to identify at-risk individuals early that would benefit from timely medical interventions. DNA methylation provides an opportunity epigenetic signature at increased risk. We utilized machine learning signatures disease data available through NCBI Gene Expression Omnibus. A training cohort 460 (164 COVID-19-infected 296 non-infected)...
Adolescents with perinatally acquired HIV (AWH) are at an increased risk of poor cognitive development yet the underlying mechanisms remain unclear. Circulating galectin-9 (Gal-9) has been associated inflammation and multimorbidity in adults despite antiretroviral therapy (ART); however, relationship between Gal-9 AWH cognition unexplored.
Background Cellular immunometabolism among people living with HIV (PLWH) on antiretroviral therapy (ART) remains under investigated. We assessed the relationships between mitochondrial oxidative phosphorylation (OXPHOS) in peripheral blood mononuclear cells (PBMCs) and parameters associated immune dysregulation. Methods PLWH ≥40 years old stable ART ≥3 months were enrolled (N = 149). OXPHOS complex I (CI, NADH dehydrogenase) IV (CIV, cytochrome c oxidase) protein levels PBMCs quantified...
<h2>Summary</h2> Despite the success of antiretroviral therapy (ART), individuals with HIV remain at risk for experiencing non-AIDS adverse events (NAEs), including cardiovascular complications and malignancy. Several surrogate immune biomarkers in blood have shown predictive value predicting NAEs; however, composite panels generated using machine learning may provide a more accurate advancement monitoring discriminating NAEs. In nested case-control study, we aimed to develop models...
The epigenome influences gene regulation and phenotypes in response to exposures. Epigenome assessment can determine exposure history aiding diagnosis.
Liver cancer presents divergent clinical behaviors. There remain opportunities for molecular markers to improve liver diagnosis and prognosis, especially since tRNA-derived small RNAs (tsRNA) have rarely been studied. In this study, a random forests (RF) diagnostic model was built based upon tsRNA profiling of paired tumor adjacent normal samples validated by independent validation (IV). A LASSO used developed seven-tsRNA-based risk score signature prognosis. Model performance evaluated...
HIV-infected individuals have a 2-fold-increased risk of cardiovascular disease compared with the general population, yet mechanisms underlying this comorbidity are unclear. Extracellular vesicles emerged as important mediators in cell-cell communication and, given what we know their biology, may drive inflammation contributing to vulnerable population.
Natural killer (NK) cells are critical modulators of HIV transmission and disease. Recent evidence suggests a loss NK cell cytotoxicity during aging, yet analysis biology aging in people with (PWH) is lacking. Herein, we perform comprehensive analyses without to determine age-related phenotypic changes. Utilizing high-dimensional flow cytometry, analyze 30 immune-related proteins on peripheral from healthy donors, PWH viral suppression, viremic PWH. phenotypes dynamic across but change...
Bien que les attitudes canadiennes envers droits à L'egalité des homosexuels soient devenues plus libérates, la condamnation morale de L'homosexualité n'a pas changé. Cela reflète tendances contradictoires dans démocraties qui d'un côte enchâssent L'individu au libre choix et L'égalité chances, L'autre imposent L'hétérosexisme normes traditionnelles basées sur famille. Quoique le soutien du public pour soit entouré messages insitutionnels contradictoires, ce rend volatile fragile, il ouvre...
Serodiscordant or magnetic couples experience HIV-related issues that can compound daily stressors. Psychoeducational group interventions build coping skills and increase relationship satisfaction. Throughout Summer 2014, 6 gay male (n = 12) collaboratively designed participated in an 8-session psychoeducational support group. The intervention was feasible (i.e., recruitment <2 weeks, it easy to coordinate) acceptable each session consistently rated very good outstanding). Relationship...
Background: Chronic HIV is associated with increased inflammation and tissue fibrosis despite suppressive antiretroviral therapy (ART). Monocytes macrophages have been implicated in the pathogenesis of fibrosis, facilitated by chemokine receptor interactions.Methods: We assessed systemic fibrotic biomarkers (transforming growth factor beta-1 [TGF-β1], thrombospondin-1 [TSP-1], C-terminal pro-peptide collagen type I [CICP], IL-11) banked plasma from a previously published 24-week open-label...
Maximum carotid plaque thickness (MCPT) measures the largest in artery and reflects atherosclerosis burden. MCPT may be a better predictor of cardiovascular disease than intima-media (cIMT) because it identifies potential unstable arterial plaques. We assessed relationships monocyte T cell populations plasma soluble mediators with measures. performed cross-sectional small follow-up analysis people living HIV (PLWH) aged >40 years on stable antiretroviral therapy (ART) >6 months. was acquired...
Although effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH), prevalence milder forms HIV-associated neurocognitive disorders (HAND) persist, and it is associated systemic neuro-inflammatory processes that could impact other organ systems. However, complex signaling mechanisms between bone-kidney systems brain in HAND remain unknown. Extracellular vesicles (EVs) play a potential role inter-organ communication are involved regulating cell activity...
Despite the success in management of HIV with antiretroviral therapy (ART), people (PWH) have a heightened state immune activation and inflammation, an estimated 10%-40% demonstrate poor CD4 T-cell reconstitution, thereby increasing their mortality morbidity risk burden. Soluble immunoregulatory proteins that function lymphocyte or inhibition are elevated PWH associate dysfunction, persistence, predictive comorbid outcomes. Here, we measured panel 35 circulating 116 variations counts (poor...
Abstract Neurocognitive impairment is a prevalent and important co-morbidity in virologically suppressed people living with HIV (PLWH), yet the underlying mechanisms remain elusive treatments lacking. Here, we explored for first time, use of participant-derived directly induced neurons (iNs) to model neuronal biology injury PLWH. iNs retain age-and disease-related features donors, providing unique opportunities reveal novel aspects neurological disorders. We obtained primary dermal...
A segment of people with HIV on effective antiretroviral therapy (ART) continue to experience poor immune recovery, leaving them at heightened risk non-AIDS-defining events (NAEs). The production anti-CD4 IgG autoreactive antibodies is suggested as one contributing mechanism these complications. Here, we found that plasma levels do not discriminate immunological responders from nonresponders nor predict the occurrence NAEs, suggesting it unlikely a immunopathological factor associated
People with HIV (PWH) on combined antiretroviral therapy (cART) are living longer lives due to modern cART advances and increased routine medical care. The full landscape of aging is unclear; given that emerged relatively recently in human history initially had a high mortality rate, there has not been substantially aged population evaluate. In the present study, we set out perform throughput plasma analyte profiling by multiplex analysis, focusing various T helper (Th)-related cytokines,...
People with HIV (PWH) on combination antiretroviral therapy (cART) are living longer lives due to modern cART advances and increased routine medical care. The full landscape of aging is unclear; given that emerged relatively recently in human history initially had a high mortality rate, there has not been substantially aged population evaluate. In this study, we set out perform high-throughput plasma analyte profiling by multiplex analysis, focusing various T helper (Th)-related cytokines,...