A5055821629- Statistical Methods and Inference
- Advanced Causal Inference Techniques
- HIV-related health complications and treatments
- Statistical Methods in Clinical Trials
- HIV Research and Treatment
- Primary Care and Health Outcomes
- Optimal Experimental Design Methods
- Statistical Methods and Bayesian Inference
- Malaria Research and Control
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Research and Interventions
- Advanced Multi-Objective Optimization Algorithms
- Hemophilia Treatment and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Statistical Methods and Models
- Complement system in diseases
- Drug Transport and Resistance Mechanisms
- Exercise and Physiological Responses
- Mitochondrial Function and Pathology
- Mental Health Treatment and Access
- Dementia and Cognitive Impairment Research
- Migration, Health and Trauma
- Colorectal Cancer Screening and Detection
- Global Health Workforce Issues
- HIV/AIDS drug development and treatment
University of Hawaiʻi at Mānoa
2016-2024
University of California, Los Angeles
2024
Hawaii Pacific University
2024
Kuakini Medical Center
2021
Honolulu University
2020
University of Hawaii System
2020
University of Louisville Hospital
2016
Background Cellular immunometabolism among people living with HIV (PLWH) on antiretroviral therapy (ART) remains under investigated. We assessed the relationships between mitochondrial oxidative phosphorylation (OXPHOS) in peripheral blood mononuclear cells (PBMCs) and parameters associated immune dysregulation. Methods PLWH ≥40 years old stable ART ≥3 months were enrolled (N = 149). OXPHOS complex I (CI, NADH dehydrogenase) IV (CIV, cytochrome c oxidase) protein levels PBMCs quantified...
Objectives: Chemokine receptor CCR5 is the principal co-receptor for entry of M-tropic HIV virus into immune cells. It expressed in central nervous system and may contribute to neuro-inflammation. The antagonist maraviroc (MVC) has been suggested improve HIV-associated neurocognitive impairment (NCI). Design: A double-blind, placebo-controlled, 48-week, randomized study MVC vs placebo people living with (PLWH) on stable antiretroviral therapy (ART) > 1 year Hawaii Puerto Rico plasma RNA...
Background: Racial/ethnic differences have not been adequately addressed in the utilization of mental health services among Medicaid populations. Aim: This study aimed to examine racial/ethnic for disorders a adult population aged between 21 and 64 years. Methods: inpatient, outpatient emergency department were assessed using 2010 Hawaii data. Zero-inflated negative binomial regressions employed adjusting age, sex residential area. Results: Among 73,200 beneficiaries, 29.7% Whites, 28.5%...
In this work, we propose a novel method for individualized treatment selection when the response is multivariate. For K (K ≥2) scenario compare quantities that are suitable indexes based on outcome variables each conditional patient-specific scores constructed from collected covariate measurements. Our covers any number of treatments and variables, it can be applied broad set models. The proposed uses rank aggregation technique to estimate an ordering ranked lists performance measures such...
Background: Chronic HIV is associated with increased inflammation and tissue fibrosis despite suppressive antiretroviral therapy (ART). Monocytes macrophages have been implicated in the pathogenesis of fibrosis, facilitated by chemokine receptor interactions.Methods: We assessed systemic fibrotic biomarkers (transforming growth factor beta-1 [TGF-β1], thrombospondin-1 [TSP-1], C-terminal pro-peptide collagen type I [CICP], IL-11) banked plasma from a previously published 24-week open-label...
Abstract Background The primary antibody (Ab) response to Plasmodium falciparum is a critical step in developing immunity malaria. Information on the initial Ab responses of babies malaria-endemic areas incomplete, part, because receive maternal IgG via transplacental-transfer and usually become infected before wanes. study aimed identify IgM malarial antigens Cameroonian babies. Methods Infants (n = 70) living high malaria transmission area were followed from birth throughout first year...
Plasmodium falciparum infections are especially severe in pregnant women because infected erythrocytes (IE) express VAR2CSA, a ligand that binds to placental trophoblasts, causing IE accumulate the placenta. Resulting inflammation and pathology increases woman's risk of anemia, miscarriage, premature deliveries, having low birthweight (LBW) babies. Antibodies (Ab) VAR2CSA reduce parasitaemia improve pregnancy outcomes. Currently, no single assay is able predict if woman has adequate immunity...
In this work we propose a novel method for treatment selection based on individual covariate information when the response is multivariate and data are available from crossover design. Our covers any number of treatments it can be applied broad set models. The proposed uses rank aggregation technique to estimate an ordering ranked lists performance measures such as smooth conditional means probability one dominating others. An empirical study demonstrates in finite samples.
In this work, we propose a novel method for individualized treatment selection when the response is multivariate. Our covers any number of treatments and it can be applied broad set models. The proposed uses Mahalanobis-type distance measure to establish an ordering based on performance measures. investigation in work deals with means responses conditional lower dimensional composite scores covariates where these are built using single index models approximate mean against patient...
Abstract In this work, we propose a method for individualized treatment selection when there are correlated multiple responses the () scenario. Here use ranks of quantiles outcome variables each conditional on patient‐specific scores constructed from collected covariate measurements. Our covers any number treatments and using it can be applied broad set models. We rank aggregation technique combining several lists where both these elements within list correlated. The has flexibility to...
It is interesting to study the consistency of outcomes arising from two genomic platforms: Microarray and RNAseq, which are established on fundamentally different technologies. This topic has been frequently discussed prospect comparing differentially expressed genes (DEGs). In this study, we explore inter-platform concordance between microarray RNASeq in their ability classify samples based information. We use a set 7 standard multi-class classifiers an adaptive ensemble classifier...
Rheumatoid arthritis (RA) is a chronic autoimmune disease initiated and progressed by RA synovial fibroblast cells (RASFs) of the synovium. Inflammatory cytokines/chemokines play crucial role in development. Myostatin (MSTN) widely comprehended as significant regulator pro-inflammatory many other diseases. However, its during progression still unclear. We hypothesized that MSTN regulates inflammatory expression RASFs. The immortalized RASF (MH7A) were treated with or inhibitor (0, 10, 20...
Cardiometabolic disorders may accelerate the progression of Alzheimer's disease (AD), potentially impacting ethnic-racial groups with a higher prevalence diabetes, obesity, and cardiovascular disease, though limited data exists on Native Hawaiians Pacific Islanders (NHPI) populations. This study aims to examine diabetes associated comorbidities among AD patients from different - Asians, Whites, NHPIs in Hawaii, focus identifying risk factors linked AD. A retrospective review was conducted...
We propose a novel personalized concept for the optimal treatment selection situation where response is multivariate vector that could contain right-censored variables such as survival time. The proposed method can be applied with any number of treatments and outcome variables, under broad set models. Following working semiparametric Single Index Model relates covariates responses, we first define patient-specific composite score, constructed from individual covariates. then estimate...
Abstract Background The survival outcomes following an Alzheimer’s disease (AD) diagnosis hold significant importance for health management, caregivers, patients, and their families. Hawaii is known as the most diverse ethnic population in United States there exist racial disparities. This study investigates racial/ethnic disparities among AD patients develops Machine Learning models overall prediction, utilizing Medicare data. Method We utilized nine years of data to gather information on...
In this work, we propose a semiparametric method for estimating the optimal treatment given patient based on individual covariate information that when data from crossover design are available. Here, assume there carry‐over effects patients switching one to another. For K ( ≥ 2) scenario, show nonparametric estimation of can have undesirable property comparison means only be done using independent outcome measurements different groups rather than available joint each patient. To overcome...
Abstract Increased risk of atherosclerotic cardiovascular diseases is common in HIV+ adults on stable antiretroviral treatment (ART). A key step the development plaque transmigration monocytes to area and their differentiation into macrophages eventually foam cells. The objective this study was determine if propensity transmigrate as well ability take up efflux cholesterol affected by HIV infection. Monocytes (transmigration) differentiated (lipid metabolism) from ART treated patients were...