A5072330250- HIV Research and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Caveolin-1 and cellular processes
- Cellular Mechanics and Interactions
- Tryptophan and brain disorders
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Protein Kinase Regulation and GTPase Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Reproductive System and Pregnancy
- Protein Tyrosine Phosphatases
- SARS-CoV-2 and COVID-19 Research
- Nicotinic Acetylcholine Receptors Study
- HIV/AIDS Research and Interventions
- Anesthesia and Neurotoxicity Research
- Vagus Nerve Stimulation Research
- Cell Adhesion Molecules Research
Feinstein Institute for Medical Research
2025
Northwell Health
2025
Cornell University
2023-2024
Weill Cornell Medicine
2023-2024
Advanced Center for Chronic Diseases
2019-2024
University of Chile
2019-2024
Albert Einstein College of Medicine
2022
HIV-1-associated neurocognitive impairment (HIV-1-NCI) is marked by ongoing and chronic neuroinflammation with loss decline in neuronal function even when antiretroviral drug therapy (ART) successfully suppresses viral replication. Microglia, the primary reservoirs of HIV-1 central nervous system (CNS), play a significant role maintaining this neuroinflammatory state. However, understanding how generated sustained HIV-1, or impacted ART, difficult due to limited access human CNS tissue. We...
Cancer cells often display impaired mitochondrial function, reduced oxidative phosphorylation, and augmented aerobic glycolysis (Warburg effect) to fulfill their bioenergetic biosynthetic needs. Caveolin-1 (CAV1) is a scaffolding protein that promotes cancer cell migration, invasion, metastasis in manner dependent on CAV1 phosphorylation tyrosine-14 (pY14). Here, we show expression increased rates, while respiration was by inhibition of the complex IV. These effects correlated with reactive...
: The renin-angiotensin receptor AT2R controls systemic blood pressure and is also suggested to modulate metastasis of cancer cells. However, in the latter case, mechanisms involved downstream remain be defined. We recently described a novel Caveolin-1(CAV1)/Ras-related protein 5A (Rab5)/Ras-related C3 botulinum toxin substrate 1 (Rac1) signaling axis that promotes melanoma, colon, breast Here, we evaluated whether antimetastatic effect connected inhibition this pathway. found murine...
HIV-associated neurocognitive impairment (HIV-NCI) persists in 15-40% of people with HIV (PWH) despite effective antiretroviral therapy. HIV-NCI significantly impacts quality life, and there is currently no treatment for it. The development complex mediated, part, by the entry HIV-infected mature monocytes into central nervous system (CNS). Once CNS, these cells release inflammatory mediators that lead to neuroinflammation, subsequent neuronal damage. Infected may infect other CNS as well...
Inflammation contributes to the genesis and progression of chronic diseases, such as cancer neurodegeneration. Upregulation integrins in astrocytes during inflammation induces neurite retraction by binding neuronal protein Thy-1, also known CD90. Additionally, Thy-1 alters astrocyte contractility movement mechano-sensors V3 integrin Syndecan-4. However, contribution Syndecan-4 shortening following Thy-1–V3 interaction remains unknown. To further characterize Thy-1-dependent outgrowth...
Efferent cholinergic signaling is a critical and targetable source of immunoregulation. The vagus nerve (VN) the primary in body, partially innervates hepatic functionality through liver-brain axis. Virus-induced disruption may promote pathogenesis hepatotropic neurotropic viruses. Therefore, restoring VN could be novel therapeutic strategy to alleviate pathogenic inflammation viral infections alike. In this minireview, we discuss physiological importance maintaining axis homeostasis. Next,...
Astrogliosis is a process by which astrocytes, when exposed to inflammation, exhibit hypertrophy, motility, and elevated expression of reactivity markers such as Glial Fibrillar Acidic Protein, Vimentin, Connexin43. Since 1999, our laboratory in Chile has been studying molecular signaling pathways associated with "gliosis" reported that reactive astrocytes upregulate Syndecan 4 α
Abstract Neurocognitive impairment is a prevalent and important co-morbidity in virologically suppressed people living with HIV (PLWH), yet the underlying mechanisms remain elusive treatments lacking. Here, we explored for first time, use of participant-derived directly induced neurons (iNs) to model neuronal biology injury PLWH. iNs retain age-and disease-related features donors, providing unique opportunities reveal novel aspects neurological disorders. We obtained primary dermal...