A5100407282- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Parkinson's Disease Mechanisms and Treatments
- Phytochemical compounds biological activities
- Virus-based gene therapy research
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Cancer, Hypoxia, and Metabolism
- High Altitude and Hypoxia
- Mental Health Treatment and Access
- Wnt/β-catenin signaling in development and cancer
- RNA regulation and disease
- Respiratory viral infections research
- Psychosomatic Disorders and Their Treatments
- Epigenetics and DNA Methylation
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Developmental Biology and Gene Regulation
- RNA Research and Splicing
- RNA modifications and cancer
Jingzhou Central Hospital
2024-2025
Yangtze University
2024-2025
Fudan University
2013-2025
St. Jude Children's Research Hospital
2025
Fuyang City People's Hospital
2024
First Hospital of Jilin University
2024
Jilin University
2024
Anhui University
2024
First Affiliated Hospital of Guangzhou Medical University
2022-2023
State Key Laboratory of Respiratory Disease
2022-2023
ABSTRACT A range of gram-negative bacterial species use N -acyl homoserine lactone (AHL) molecules as quorum-sensing signals to regulate different biological functions, including production virulence factors. AHL is also known an autoinducer. An autoinducer inactivation gene, aiiA , coding for lactonase, was cloned from a isolate, Bacillus sp. strain 240B1. Here we report identification more than 20 isolates capable enzymatic AHLs sources. Eight showing strong AHL-inactivating enzyme...
Accumulating evidence implicates the relationship between neuroinflammation and pathogenesis in idiopathic Parkinson's disease (iPD). The nose has recently been considered a gate way to brain which facilitates entry of environmental neurotoxin into brain. Our study aims build PD model by natural exposure route. In this report, we establish new endotoxin-based mice unilateral intranasal (i.n.) instillation lipopolysaccharides (LPS) every other day for 5 months. These display progressive...
Abstract Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between 5-HT and neurogenesis has not fully been understood. Here, we report that lowering level in adulthood is also able to enhance We used tamoxifen (TM)-induced Cre Pet1 -CreER T2 mice either deplete serotonergic (5-HTergic) neurons or inactivate synthesis explore role A dramatic increase...
ABSTRACT Hypoxia is a common phenomenon for solid tumors due to lack of effective vascular system, and has been deemed as an important factor that drives the progression thyroid cancer (TC) via altering characteristics tumor cells. The present study suggested hypoxic TC cells enhanced stem cell properties by delivering long intergenic non‐protein coding RNA 665 (LINC00665)‐containing exosomes. Specifically, TPC1 were exposed normoxic or environment, it was found cells‐secreted exosomes...
Satb2-associated syndrome (SAS) is a genetic disorder that results from the deletion or mutation of one allele within Satb2 locus. Patients with SAS show behavioral abnormalities, including developmental delay/intellectual disability, hyperactivity, and symptoms autism. To address role in SAS-related behaviors generate an mouse model, was deleted cortex hippocampus Emx1-Cre; Satb2flox/flox (Satb2 conditional knockout [CKO]) mice. CKO mice showed increased impulsivity, abnormal social...
Sonic Hedgehog (Shh) signaling plays crucial roles in patterning the ventral neural tube, which is transformed into opposing gradients of repressor and activator forms Glis. Here, we show that fine-tuning shape Gli through non-proteolytic ubiquitination-mediated nuclear exportation an important role control local cell fate. Loss RNF220, a neural-specific ubiquitin E3 ligase, leads to expansion intermediate V0 dorsal V3 neurons, while reducing V1, V2, motor neurons between them. We RNF220...
Allergic rhinitis (AR) is an IgE-mediated chronic inflammatory disease of the allergic nasal mucosa. It has a significant effect on quality life; most patients with AR also suffer from sleep disorders, mood and deterioration in social relationships. As increasing numbers medicinal plants show productive anti-inflammatory activity against diseases, there growing interest natural plant ingredients. To this end, we selected Astragalus polysaccharides (APS) to evaluate its ovalbumin-induced...
Given the importance of cerebellum in pathophysiology schizophrenia, cerebellar vermis has been proposed as a new rTMS stimulation site for negative symptoms. In this study, 64 patients from 7 psychiatric hospitals were randomized into study (n=32) or control group. Intermittent theta burst (iTBS) (or sham stimulation) to midline was administered 5 times/week 2 weeks. Psychotic symptoms assessed with Positive and Negative Symptoms Scale (PANSS) at baseline, end treatment, 2, 6, 12, 24 weeks...
Cervical cancer is one of the most common gynaecological women and suggested to be modulated by estrogenic signals. G protein‐coupled receptor (GPER), a seven‐transmembrane receptor, has been reported regulate cell proliferation various cancers. But there no study investigating effects GPER on progression cervical cancer. In present study, we revealed for first time that was also highly expressed in human cells. Activation via its specific agonist G‐1 induced G2/M cycle arrest down...
Dysfunction of central serotonin (5-HT) system has been proposed to be one the underlying mechanisms for anxiety and depression, association diabetes mellitus psychiatric disorders noticed by high prevalence anxiety/depression in patients with mellitus. This promoted us examine these behaviors 5-HT-deficient mice those also suffering Mice lacking either 5-HT or serotonergic neurons were generated conditional deletion Tph2 Lmx1b respectively. Simultaneous depletion both pancreatic islet cells...
Abstract Genome-wide association studies uncovered the of ZNF804A (Zinc-finger protein 804A) with schizophrenia (SZ). In vitro data have indicated that might exert its biological roles by regulating spine and neurite morphogenesis. However, no in vivo are available for role psychiatric disorders general, SZ particular. We generated ZFP804A mutant mice, they showed deficits contextual fear spatial memory. also observed sensorimotor gating impairment, as revealed prepulse inhibition test, but...
In this study five new limonoids, toosendone [24,25,26,27-tetra-nor-6α-acetoxy-21,22-epoxy-7α-tigloyl-1α,3α,28-trihydroxyapotirucalla-(apoeupha)-14,20,22-trien-12-one, 1] and 12-ethoxynimbolinins A - D (2 5), together with known 1-acetyltrichilinin (6), 1-cinnamoyltrichilinin (7), trichilinin B (8), 1,7-di-O-acetyl-14,15-deoxyhavanensin (9) 12-O-methylnimbolinin (10),were isolated from the fruits of Melia toosendan. Their structures relative configurations were established based on...
Abstract The retrosplenial cortex (Rsp) is a transitional located between the neocortex and archicortex, but molecular mechanism specifying Rsp from archicortex remains elusive. We here report that transcription factor Satb2 required for identity during its morphogenesis. In CKO mice, boundary [i.e., subiculum (SubC)] disappears as early E17.5, efferent projection aberrant. Rsp-specific genes are lost, whereas SubC-specific ectopically expressed in of mice. Furthermore, cell-autonomous role...
Noradrenaline belongs to the monoamine system and is involved in cognition emotional behaviors. Phox2a Phox2b play essential but non-redundant roles during development of locus coeruleus (LC), main noradrenergic (NA) neuron center mammalian brain. The ubiquitin E3 ligase Rnf220 its cofactor Zc4h2 participate ventral neural tube patterning by modulating Shh/Gli signaling,
Sensory input is generally thought to be necessary for refining and consolidating neuronal connections during brain development. We here report that cortical callosal axons in somatosensory cortex require sensory their target selection contralateral cortex. Eliminating either hemisphere by unilateral transection of infraorbital nerve (ION) prevents Strikingly, blocking bilaterally, simultaneously transecting both IONs, results rescued projection. In contrast, non-simultaneous bilateral ION...
ZC4H2 encodes a C4H2 type zinc-finger nuclear factor, the mutation of which has been associated with disorders various clinical phenotypes in human, including developmental delay, intellectual disability and dystonia. suggested to regulate spinal cord patterning zebrafish as co-factor for RNF220, an ubiquitin E3 ligase involved Gli signaling. Here we showed that RNF220 knockout animals phenocopy each other both mouse zebrafish, mispatterned progenitor neuronal domains ventral cord. We...