A5100678996- Coastal and Marine Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Immune Response and Inflammation
- Drug-Induced Hepatotoxicity and Protection
- Tropical and Extratropical Cyclones Research
- Pharmacological Effects of Natural Compounds
- Plant Stress Responses and Tolerance
- Plant Gene Expression Analysis
- Anesthesia and Neurotoxicity Research
- Coastal wetland ecosystem dynamics
- Cytokine Signaling Pathways and Interactions
- Advancements in Transdermal Drug Delivery
- Acute Kidney Injury Research
- MicroRNA in disease regulation
- Alcohol Consumption and Health Effects
- Stress Responses and Cortisol
- Liver Disease and Transplantation
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Monoclonal and Polyclonal Antibodies Research
- Vitamin C and Antioxidants Research
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
Northeast Agricultural University
2017-2025
Qingdao Agricultural University
2023-2025
Hohai University
2017-2023
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2023
Nanjing Hydraulic Research Institute
2023
Qinghai Normal University
2020
Fujian Agriculture and Forestry University
2018-2019
Chongqing Three Gorges Central Hospital
2017
Wenzhou Medical University
2011-2016
First Affiliated Hospital of Wenzhou Medical University
2011-2016
Acute stress induces tissue damage through excessive oxidative stress. Dexmedetomidine (DEX) reportedly has an antioxidant effect. However, protective roles and related potential molecular mechanisms of DEX against kidney injury induced by acute are unknown. Herein, rats were forced to swim 15 min followed restraint for 3 h with/without (30 μg/kg). Successful model establishment was validated open-field test. Assessment renal function (creatinine, urea nitrogen), histopathology,...
Acute liver injury (ALI) is a poor prognosis and high mortality complication of sepsis. Paeoniflorin (PF) has remarkable anti-inflammatory effects in different disease models. Here, we explored the protective effect underlying molecular mechanisms PF against lipopolysaccharide (LPS)-induced ALI. Sprague-Dawley rats received intraperitoneal (i.p.) injection for 7 days, 1 h after last administration, were injected i.p. 10 mg/kg LPS. improved structure function, reduced hepatic reactive oxygen...
Stage Ta/T1 urothelial carcinoma of the bladder (Ta/T1 BC) has a marked tendency to recurrence. Long noncoding RNA HOTAIR been reported be expressed in some human cancers such as breast cancer, and it may positively correlated with patient's prognosis. The aim our study was evaluate prognostic value BC. expression BC tissues adjacent normal collected from 110 patients measured by real-time quantitative PCR. relationships between clinical pathological characteristics were analyzed....
Doxorubicin (DOX) is one of the most commonly used anticancer drugs in treatment hepatoma. However, acquired drug resistance major challenges for chemotherapy. In this study, a down-regulation miR-122 was observed doxorubicin-resistant Huh7 (Huh7/R) cells compared with its parental cells, suggesting associated chemoresistance. Meanwhile, luciferase reporter assay proved that PKM2 target miR-122, and we reported glucose metabolism significantly up-regulated Huh7/R cells. Importantly,...
Chronic stress causes duodenal damage, in which iron death is likely to play an important role. Chlorogenic acid (CGA), one of the most widely consumed dietary polyphenols, has been shown protect intestine. However, it unclear whether CGA exerts a duodenoprotective effect chronic by inhibiting ferroptosis. In this work, rats were daily exposed restraint for 6 h over 21 consecutive days, with/without (100 mg/kg, gavage). reduced blood hepcidin, iron, reactive oxygen species (ROS), and...
WRKY transcription factors have been implicated in both plant immunity and responses to cadmium (Cd); however, the mechanism underlying crosstalk between these processes is unclear. Here, we characterized roles of CaWRKY41, a group III factor, against pathogenic bacterium Ralstonia solanacearum Cd stress pepper (Capsicum annuum). CaWRKY41 was transcriptionally up-regulated response exposure, R. inoculation, H2O2 treatment. Virus-induced silencing increased tolerance susceptibility, while...
Chronic stress can cause intestinal barrier damage. MAPK and NF-κB are closely related to it. Chlorogenic acid (CGA), a dietary polyphenol, has been shown have protective effects, but whether by regulating is not known. Therefore, in this experiment, 24 Wistar rats were randomly divided into 4 groups (C group, CS + SB203580, CGA group). Rats the group restrained for 6 h per day 21 days. SB203580 given SB203582 (0.5 mg/kg, intraperitoneal injection) 1 before restraint every other day. (100...
Ellagic acid displays multiple biological and pharmacological effects. Here, we explore its protective role against acute stress (AS)–induced kidney damage. We established the AS model through excessive swimming (15 min) restraint (3 h), which decreased movement exploratory behaviors in open field test. Pretreatment with ellagic (10 mg/kg, orally for 14 days) reversed these changes improved histopathological lesion renal dysfunction. Moreover, alleviated AS‐induced oxidative apoptosis. This...
Chronic stress leads to immunosuppression and induces splenocyte apoptosis. STAT3 is a transcription factor that regulates immunity apoptosis; however, it unclear whether the increased expression of phosphorylated (p-STAT3) observed in chronic related To explore relationship between apoptosis stress, we treated rats undergoing 21-day restraint program with inhibitor S3I-201. This model was verified by observing rats' behavior measuring their serum corticosterone levels. led anti-inflammatory...
Acute stress is a frequent and unpredictable disease for many animals. Stress widely considered to affect liver function. However, the underlying mechanism by which dexmedetomidine (DEX) attenuates acute stress-induced injury in rats remains unclear. In this study, we used forced swimming 15 min 3-hr restraint model. Behavioral tests changes norepinephrine levels confirmed successful establishment of injury, evidenced hematoxylin eosin-stained pathological sections increased serum...
Heat stress, an important and damaging abiotic regulates numerous WRKY transcription factors, but their roles in heat stress responses remain largely unexplored. Here, we show that pepper (Capsicum annuum) CaWRKY27 negatively basal thermotolerance mediated by H2O2 signaling. expression increased during persisted recovery. overexpression impaired tobacco (Nicotiana tabacum) Arabidopsis thaliana; CaWRKY27-overexpressing plants had a lower survival rate under accompanied decreased of multiple...
In recent years, the protective effect of hydrogensulfide donor sodium hydrosulfide(NaHS) on multiple organs has been widely reported. The study aimed to explorethe commonly used concentration NaHS theliver and its potential damage mechanism. Rats divided into 4 groups: control, I (1 mg/kg), II (3 mg/kg) III(5 groups, each group is four-timepoints (2, 6, 12, 24 hours). Results showed that H2S increased, mitochondrial complex IV activity inhibited, COX subunits apoptosis pathway-related...