A5066415651- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug Transport and Resistance Mechanisms
- Anesthesia and Neurotoxicity Research
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Boron and Carbon Nanomaterials Research
- Intensive Care Unit Cognitive Disorders
- S100 Proteins and Annexins
- DNA and Nucleic Acid Chemistry
- Graphene research and applications
- Thyroid Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Anesthesia and Sedative Agents
- Immune cells in cancer
- Carbon and Quantum Dots Applications
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
Westlake University
2025
Renji Hospital
2019-2025
Shanghai Jiao Tong University
2009-2025
Zhengzhou University
2014-2019
Jiangmen Central Hospital
2019
Indiana University School of Medicine
2019
Eastern Hepatobiliary Surgery Hospital
2015-2018
Second Military Medical University
2015-2018
Longyan University
2013-2017
Fujian Medical University
2012-2015
Although autophagy is most critical for survival of cancer cells, especially in fast-growing tumors, the mechanism remains to be fully characterized. Herein we report that PSMD10/gankyrin promotes hepatocellular carcinoma (HCC) response starvation or stress through 2 complementary routes. PSMD10 was physically associated with ATG7 cytoplasm, and this association enhanced by initial nutrient deprivation. Subsequently, translocated into nucleus bound cooperatively nuclear HSF1 (heat shock...
Methylation of the fifth position cytosine (5mC) is an important epigenetic modification DNA. It has been shown that oxidized derivatives 5mC, namely 5‐hydroxymethylcytosine (5hmC), 5‐formylcytosine (5fC), and 5‐carboxylcytosine (5caC), are in dynamic existence have distinct regulatory functions. In current study, we investigated whether there changes contents all three 5mC‐oxidized hepatocellular carcinoma (HCC) genome further explored underlying mechanisms. We showed both global genomic...
Stage Ta/T1 urothelial carcinoma of the bladder (Ta/T1 BC) has a marked tendency to recurrence. Long noncoding RNA HOTAIR been reported be expressed in some human cancers such as breast cancer, and it may positively correlated with patient's prognosis. The aim our study was evaluate prognostic value BC. expression BC tissues adjacent normal collected from 110 patients measured by real-time quantitative PCR. relationships between clinical pathological characteristics were analyzed....
The recognition and binding via receptor-ligand interactions on cell membranes often weaken in complex environments, such as whole blood samples from cancer patients, making disease diagnosis treatment evaluation unfavorable. Constructing multivalent ligands with sufficient fluid stability environments remains a challenge. Herein, we develop tetrahedral DNA framework (TDF) ensembled aptamers (TEAn, n = 1-3) programmable size, enabling efficient capture of circulating tumor cells (CTCs)...
Abstract The recognition and binding via receptor‐ligand interactions on cell membranes often weaken in complex environments, such as whole blood samples from cancer patients, making disease diagnosis treatment evaluation unfavorable. Constructing multivalent ligands with sufficient fluid stability environments remains a challenge. Herein, we develop tetrahedral DNA framework (TDF) ensembled aptamers (TEA n , = 1–3) programmable size, enabling efficient capture of circulating tumor cells...
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an involved in carcinogenesis, has been associated with evasion and energy metabolism reprogramming. This study aimed examine the molecular mechanisms underlying involvement of NSUN2 metabolic reprogramming HCC. Methods Single‐cell transcriptomic sequencing was applied cellular composition changes, particularly...
We report the first sub-1 cm⁻¹ resolution high-resolution broadband sum-frequency generation vibrational spectroscopy (HR-BB-SFG-VS) ssp intensity spectra of air/neat-water interface across 1500–3900 spectral range. Utilizing a direct fitting approach, we reconstruct phase-resolved that quantitatively agree with previously reported measurements while revealing additional features and phase information. This combined analysis advances molecular-level understanding water’s dynamics orientation...
Interleukin-1 receptor associated kinase 1 (IRAK1), as a down-stream of toll-like (TLR) signaling, plays important roles in series malignancies. However, the role IRAK1 hepatocellular carcinoma (HCC) remains little known. In our study, reverse transcription-PCR (RT-PCR), Western Blot, and immunohistochemical staining were used to assess mRNA protein levels clinical samples cell lines. Cell counting assay flow cytometry employed analyze effect on cycle apoptosis. Transwell was study...
Introduction The novel coronavirus (COVID-19) is currently in epidemic stage. After large-scale interpersonal infection, asymptomatic patients appear. Whether are contagious or not and whether they need medication the arguments among clinical experts.
We report a series of novel O-(substituted benzyl) phosphoramidate prodrugs 5-fluoro-2'-deoxyuridine for the treatment hepatocellular carcinoma. Through structure optimization, o-methylbenzyl analog (1t) was identified as an orally bioavailable and liver-targeted lead compound. This prodrug is well-tolerated at dose up to 3 g/kg in Kuming mice via oral administration. An efficacy study demonstrated that it possesses good inhibitory effect (61.67% 72.50%, respectively) on tumor growth mouse...
Abstract Satellite nodules is a key clinical characteristic which has prognostic value of hepatocellular carcinoma (HCC). Currently, there no gene-level predictive model for in liver cancer. For the 377 HCC cases collected from dataset Cancer Genome Atlas (TCGA), their original pathological data were analyzed to extract information regarding satellite status as well other relevant data. Then, this study employed statistical modeling establishment TCGA, and validation International Consortium...
In addition to the important roles played by 5-methylcytosine (5mC), emerging evidence suggests that 5mC derivatives, such as 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), also exhibit regulatory functions in physiological pathological processes. Four cytosine modifications (5mC, 5hmC, 5fC 5caC) are produced erased a cyclic enzymatic cascade mediated DNA methyltransferases (DNMTs), ten-eleven translocation (TET) family enzymes thymine glycosylase...
Here, we report the synthesis of nitrogen-doped fluorescent carbon (C) dots using a one-pot hydrothermal method. Transmission electron microscopy results reveal that particle size C-dots is very small, with an average diameter 4.6 nm. After being kept in water for 10 days, can still dissolve well water, showing good stability and compatibility aqueous solution. The fluorescence spectra show exhibit emission-tunable color from blue to green upon excitation 230 520 Cell tests are low...
5-Hydroxymethylcytosine (5hmC) with dynamic existence possesses multiple regulatory functions. Whereas, 5hmC's impact on small hepatocellular carcinoma (SHCC) remains unclear. The present work focused characterizing 5hmC content within SHCC and assessing the possibility of using global genomic level as predicative factor clinical outcome.This study applied ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in measuring 5mC, 5fC contents. In addition,...