A5100455027- Anesthesia and Neurotoxicity Research
- Ion Channels and Receptors
- Cardiac Ischemia and Reperfusion
- Pain Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Pharmacological Effects of Natural Compounds
- Enhanced Recovery After Surgery
- Medical and Biological Ozone Research
- Pediatric Pain Management Techniques
- Chemotherapy-induced organ toxicity mitigation
- Sirtuins and Resveratrol in Medicine
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Osteomyelitis and Bone Disorders Research
- Pain Management and Opioid Use
- Apelin-related biomedical research
- Uterine Myomas and Treatments
- Head and Neck Surgical Oncology
- Pregnancy-related medical research
- Endometrial and Cervical Cancer Treatments
- Axon Guidance and Neuronal Signaling
- Cancer-related molecular mechanisms research
- Gynecological conditions and treatments
- Vascular Malformations Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
Central South University
2011-2025
Xiangya Hospital Central South University
2025
Second Xiangya Hospital of Central South University
2011-2024
Women's Hospital, School of Medicine, Zhejiang University
2024
Beijing Anding Hospital
2023
Capital Medical University
2023
Chongqing Medical University
2023
Wenzhou Medical University
2021
Zhejiang Taizhou Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2020
Background: Osteoporosis (OP) is a systemic bone disease often undiagnosed until fractures occur. Metabolites may influence OP, offering potential biomarkers or therapeutic targets. This study investigates the causal relationship between circulating metabolites and OP-related phenotypes using Mendelian Randomization (MR). Methods: GWAS data on 233 metabolic traits from 136,016 participants were analyzed through two-sample MR. Linkage disequilibrium score regression (LDCS) was used to...
Angelica Sinensis polysaccharide (ASP), the main active component of sinensis, possesses antioxidative and anti-apoptotic properties. In this study, we have investigated antagonistic effect ASP on 5-FU-induced injury mouse spleen in vivo splenocytes vitro, its possible mechanism. Our results showed that inhibited decreases weight organ index mice, restored number peripheral blood leukocytes lymphocytes, repaired structure disorder functional impairment, rescued serum IL-2, IL-6, IFN-γ...
Neuropathic pain often occurs during chemotherapy with oxaliplatin. AG490 has been shown to exert an antagonistic effect on inflammatory pain, but its oxaliplatin-induced neuropathic remains poorly understood. This study sought observe the analgesic of acute induced by a single oxaliplatin treatment and address possible mechanism. In this study, we established model intraperitoneal injection 6 mg/kg On day 2 after injection, models were intraperitoneally injected 1, 5, or 10 AG490. Paw...
BACKGROUND: Patients with craniofacial cancer frequently suffer from severe pain. The traditional intrathecal, oral, or intravenous analgesics could only provide insufficient pain relief many side effects. Thus, a more effective analgesia approach is required. This study aimed to investigate the safety and efficacy of placing catheter an intrathecal morphine pump in prepontine cistern for treatment METHODS: We performed retrospective patients primary metastatic who received placement into...
Bed rest during pregnancy can lead to reduced physical activity, impairing lower limb venous blood flow and increasing the risk of deep vein thrombosis (DVT) muscle atrophy. We investigated clinical efficacy foam rolling intervention (FRI) in enhancing flow, mitigating DVT atrophy pregnant women on bed rest.
Gadolinium-based MR cisternography has been mainly applied in clinical evaluation of cerebrospinal fluid leaking, that is conducted by intrathecal administration contrast media. Recently, we have reported one novel technique targeted drug delivery with prepontine cisternal routine to treat orofacial cancer pain. The aim this study was examine the distribution pattern strategy. Here, introduce case who suffered severe pain caused sublingual gland tumor, and successfully attenuated analgesic...
Oral tongue squamous cell carcinoma (OTSCC) is the most common type of oral carcinomas. However, molecular mechanism by which OTSCC developed not fully identified. Stromal interaction molecule 1 (STIM1) a transmembrane protein, mainly located in endoplasmic reticulum (ER). STIM1 involved several types cancers. Here, we report that contributes to development human OTSCC. We knocked down line Tca-8113 with lentivirus-mediated shRNA and found knockdown repressed proliferation cells. In...
The purpose of this study was to explore the causative effects high-velocity bullet injury (5.56 mm, 930 m/sec) combined with hemorrhagic shock on gut-derived endotoxemia and multiple system organ dysfunction or failure. concentration endotoxin in both portal systemic blood markedly increased after gunshot wounds together (p < 0.05-0.01). portal/systemic lipopolysaccharide ratio persistently decreased wound (CW) group at 24 72 hours injury, it much lower CW than that single (SW) group. Also,...
Abstract Objective: The aim of the study was to provide reference values for sonographic measurements uterine morphology, quantify changes in morphology across menopausal transition, and identify possible factors associated with findings morphology. Methods: This is a longitudinal cohort conducted middle-aged Chinese women. Using transvaginal ultrasound, we measured morphologic parameters uterus (volume endometrial thickness) under standardized conditions every year over decade. Results:...
Chronic stress models, established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone, once per day, were given daily oral feeding 50 baicalin. The study was an attempt to observe the effect baicalin on neurogenesis chronically stressed rats. Results showed that corticosterone significantly decreased total number doublecortin-positive neurons hippocampus. reduced cell caused by mainly due decrease class II neurons, but I unaffected. Baicalin...
To evaluate the effect of biglycan on signaling cytokines (epidermal growth factor, osteogenic protein-1, and interleukin-1) in bovine intervertebral disc cells.Nucleoplasty (NP) annulus fibrosus (AF) cells tissues were isolated from tails young adult bovine. First, treated 3 ways: Biglycan alone, alone or interleukin-1), combined with cytonkines. Western blot was used to observe singling cells, identify mentioned above.Biglycan upregulated (3- 4 folds) optimal at 10 min 20 μmol/L both AF NP...
To detect the effect of pulse radiofrequency (PRF) treatment on neuropathic pain established by L5-spinal nerve ligation (SNL) rats, and to investigate if PRF would affect expression autophagy related protein LC3 receptor P62 at dorsal horn. Methods: A total 36 male Sprague-Dawley rats were randomly divided into 3 groups: a Sham group, SNL SNL+PRF group. The 50% paw withdrawal mechanical threshold (PWMT) was detected 1 day before 1, 3, 7, 14 28 days post-operation using Von-Frey filaments....
Objective To detect the expression of a circadian gene, hPer2, in human colorectal carcinoma, and analyze its relation to clinico-pathological data.Methods The hPer2 was detected 38 paired eolorectal carcinoma tissues surrounding non-cancerous by immunohistochemical staining.The relationship between several clinicopathological parameters analyzed.Results protein positively stained 81.6% (31/38) 97.4% (37/38) (P < 0.05).Compared with tissues, decreased 24 cases (63.1%), increased 2 eases...
目的探讨SIRT1/NF-κB信号轴在人参皂苷Rg1对抗衰老模型大鼠造血干/祖细胞衰老中的作用。 方法6~8周雄性SD大鼠50只，随机分为对照组、模型组、人参皂苷Rg1对照组、人参皂苷Rg1治疗组和人参皂苷Rg1预防组，每组10只。以连续42 d sc D-半乳糖（D-gal）制备衰老动物模型，人参皂苷Rg1各组ip给药不同时间，药物注射完成第2天，免疫磁性分选法分离纯化各组Sca-1+造血干/祖细胞（HSC/HPC），衰老相关β-半乳糖苷酶（SA-β-Gal）染色、流式细胞周期分析和造血祖细胞混合集落（CFU-Mix）培养观察人参皂苷Rg1对Sca-1+ HSC/HPC抗衰老的生物学作用。荧光定量PCR及Western blotting检测衰老调控分子SIRT1、NF-κB mRNA及蛋白的表达。 结果与模型组比较，人参皂苷Rg1治疗组和预防组SA-β-Gal染色阳性率、G0/G1期细胞比例下降，生成CFU-Mix数增高，SIRT1 mRNA及蛋白表达上调，NF-κB mRNA及蛋白表达下调；人参皂苷Rg1预防组各指标变化均较人参皂苷Rg1治疗组明显。 ...
Objective To investigate the analgesia effect and possible mechanism of intravenous administration with different concentrations ozonized saline (OS) by observing changes in behavior, plasma tumor necrosis alpha (TNF-α), interleukin-6 (IL-6) levels after rat plantar incision. Methods Fifty-four health adult male Sprague-Dawley rats were used investigation. Twenty four randomly divided into groups, 6 each group. The group A1 intravenously administered 5ml/kg oxygen saline, 10min before...
Gastrointestinal (GI) disorders are widely recorded in Autism spectrum disorder (ASD), and ASD with GI symptoms is a vital subtype of this disease. Growing evidence suggests altered gut microbiota biomarkers ASD, but little known about the individuals Symptoms, particularly early childhood. In our study, 36 along 40 typically developing (TD) children were compared using 16S rRNA gene sequencing. The microbial diversity composition found to differ between two groups. Compared TD, patients...