A5057052304- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Colorectal Cancer Surgical Treatments
- Pelvic and Acetabular Injuries
- Pediatric Pain Management Techniques
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Inflammatory mediators and NSAID effects
- Cancer, Hypoxia, and Metabolism
- Neurological diseases and metabolism
- Cancer Research and Treatments
- Pharmacological Effects and Toxicity Studies
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Diverticular Disease and Complications
- Pain Management and Opioid Use
- Inflammatory Bowel Disease
- Gallbladder and Bile Duct Disorders
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
Second Xiangya Hospital of Central South University
2021-2024
Central South University
2021-2024
The intrinsic mechanism of postherpetic neuralgia (PHN) remains unclear. Herein, we aimed to seek the hub proteins in cerebrospinal fluid (CSF), which display significant changes between PHN and nonpainful patients (Control). First, proteomic results showed that compared with Control-CSF, there were 100 upregulated 50 downregulated differentially expressed (DEPs) PHN-CSF. Besides, functional analyses including gene ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), set enrichment...
Abstract The potential for tumor occurrence triggered by cancer stem cells (CSCs) has emerged as a significant challenge human colorectal therapy. However, the underlying mechanism of CSC development remains controversial. Our study provided evidence that bulk could dedifferentiate to CSCs and reacquire CSC‐like phenotypes if cultured in presence extracellular matrix reagents, such Matrigel fibrin gels. In these 3D gels, CD133 − can regain tumorigenic stem‐like phenotypes. Mechanistically,...
Photodynamic therapy (PDT) is considered a potential treatment regimen for colorectal cancer cases (CRC). p53 signaling and the miR-124/iASPP axis play an essential role in PDT resistance of CRC cells. downregulated NEAT1 expression wt HCT116 RKO In these two cell lines, silencing enhanced suppressive effects on viability apoptosis. Within subcutaneously implanted tumor model, PDT-induced suppression growth. Regarding p53-deleted cells, only moderately affected proliferation but induced...
BACKGROUND: Patients with craniofacial cancer frequently suffer from severe pain. The traditional intrathecal, oral, or intravenous analgesics could only provide insufficient pain relief many side effects. Thus, a more effective analgesia approach is required. This study aimed to investigate the safety and efficacy of placing catheter an intrathecal morphine pump in prepontine cistern for treatment METHODS: We performed retrospective patients primary metastatic who received placement into...
Background: Chromosome 5 open reading frame 46 ( C5ORF46 ), also known as antimicrobial peptide with 64 amino acid residues AP-64 ) and skin saliva-secreted protein 1 SSSP1 belongs to the family of genes encodes a small exosomal protein. has been implicated in antibacterial activity associated patient prognosis pancreatic cancer, colorectal stomach cancer. These findings highlight importance gastrointestinal (GI) tumor inception development. However, prognostic immunological value human GI...
Abstract Objective To compare and analyze the differences in safety, feasibility short-term efficacy between robot-assisted totally robotic surgery Right Hemicolectomy. Methods A retrospective analysis was conducted on clinical data of 184 patients who underwent right hemicolectomy The Second Xiangya Hospital Central South University from July 2016 to December 2021. 148 were matched (including 74 cases (TRAH) (TRRH)). general information, surgical pathological results complications collected...
Drugs and therapies available for the treatment of inflammatory bowel disease (IBD) are not satisfactory. Our previous study has established inhibitor apoptosis-stimulating p53 protein (iASPP) as an oncogenic regulator in colorectal cancer by forming a regulatory axis or feedback loop with miR-124, p53, p63. As iASPP could target inhibit nuclear factor kappa B (NF-κB) activation, this role mechanism IBD was investigated. The aberrant up-regulation subsequently confirmed, based on online data...