A5090596165- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Bioactive Compounds and Antitumor Agents
- Cancer, Hypoxia, and Metabolism
- Phytochemistry and biological activity of medicinal plants
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Transplantation: Methods and Outcomes
- Signaling Pathways in Disease
- HER2/EGFR in Cancer Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Coenzyme Q10 studies and effects
- Sulfur-Based Synthesis Techniques
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Circular RNAs in diseases
- Food Science and Nutritional Studies
- Phytochemistry and Bioactivity Studies
- Curcumin's Biomedical Applications
Guangxi Medical University
2016-2024
Anhui Polytechnic University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Anhui Medical University
2014-2022
First Affiliated Hospital of Anhui Medical University
2014-2022
State Administration of Foreign Experts Affairs
2012
Novel anthraquinone compounds that induce ER stress and paraptosis-like cell death were designed synthesized. Compound 4a is the first organic micromolecule to kill tumor cells by only paraptosis, its mechanism of action has been further explored. Paraptosis does not appear involve either phosphatidylserine translocation associated with apoptosis or cycle arrest. The bisbenzyloxy N-(2-hydroxyethyl)formamide structures may be two critical pharmacophores for paraptosis. Bisbenzyloxy can...
Cytoplasmic epidermal growth factor receptor (EGFR) is overexpressed in both nasopharyngeal carcinoma (NPC) and triple-negative breast cancer (TNBC), while clinical outcome prognosis vary greatly among patients treated with gefitinib, all eventually develop resistance to this agent. Therefore, we propose a new concept for synthesizing multitarget compounds reveal therapeutic strategies NPC TNBC expressing EGFR. Compound H was synthesized our previous study. Molecular docking cell thermal...
This study aims to analyze the expression level and correlation of miR-182-5p its target gene PAPPA in coronary atherosclerosis (CAD).Real time PCR, ELISA, Western blotting methods were used detect levels. Dual-luciferase reporter assays interaction between 3'-UTR miR-182-5p.The CAD was significantly lower than that normal population, while content serum increased, negatively correlated with content. The decreased, increased ox-LDL treated HA-VSMC cells. Researchers found could promote...
Background: Increasing evidence indicates that vitamin D deficiency negatively affects the cardiovascular system. Here we studied therapeutic effects of calcitriol in myocardial infarction (MI) and investigated its underlying mechanisms. Methods: A MI model Kun-ming mice induced by left anterior descending coronary artery ligation was utilized to study potential on MI. AC16 human cardiomyocyte-like cells treated with TNF-α were used for exploring mechanisms underlie cardioprotective...
A new strategy for the preparation of 3-halobenzo[b]thiophenes via a photo-driven halocyclization/demethylation 2-alkynylthioanisoles with simple alkyl halides was developed. The reaction can proceed smoothly at room temperature under visible-light irradiation without any external photocatalyst, and protocol has range advantages, including simplicity mildness conditions, good functional-group tolerance, excellent yields products.
Aim: The EGF receptor (EGFR) is overexpressed in multiple epithelial-derived cancers and considered to be a vital target closely associated with cancer therapy. In this study, series of novel anthraquinone−quinazoline hybrids targeting several sites for therapy were designed synthesized. Methodology & results: Most the synthesized demonstrated excellent antiproliferative activity downregulation expression EGFR. most promising compound 7d showed strongest antiproliferation activity;...
Cardiac hypertrophy is a compensatory mechanism that occurs in conjunction with cardiovascular diseases. Although of the myocardium provides certain benefits during early stages disease, prolonged potentially harmful to heart and can result arrhythmia failure. The aim this study was investigate whether an ATP‑sensitive K+ (KATP) channel agonist capable reducing isoproterenol (Iso)‑induced cardiac modulating myocardial connexin43 (Cx43) expression. Fifty male Sprague Dawley rats were randomly...
We reported in an earlier study that using mass spectrometry and bioinformatic analysis demonstrated Rac1 protein might be mostly mitochondrial target the radiosensitization process of nasopharyngeal carcinoma CNE-1 cells. The goal our current was to reveal relationship between Rac1/NADPH pathway cells activator, phorbol 12-myristate 13-acetate (PMA) inhibitor NSC23766. Rac1-GTP expression determined a pulldown assay, location immunofluorescence with laser scanning confocal microscope, NADPH...
ABSTRACT The aim of this study was to investigate the possibility APC/C Cdh1 as a potential therapeutic target in radiosensitivity nasopharyngeal carcinoma (NPC) cell CNE‐1, and explain role APC subunits after silence combined with radiotherapy. Transfection shRNA significantly increased CNE‐1 cells radiation enhancement ratio (RER) sh‐Cdh1 1.76. Knockdown irradiation induced apoptosis G2/M phase cycle arrest. levels CDC20 CylinB1 Ku70 APC3 decreased irradiation. is involved regulation human...
Background: Endoplasmic reticulum (ER) stress is a therapeutic target in cancer given its regulation of bioenergetics and cell death. Methodology & results: We synthesized 14 ER stress-triggered anthraquinone derivatives by introducing an amino group at the 3-position side chain lead compound obtained previously. Most exhibited good antitumor activity due to their ability induce damage through cytoplasmic vacuoles. The mechanisms caused KA-4c were related increasing expression levels ATF6...
Fufang Qinlan oral liquid (QLOL) is a traditional Chinese medicine formula used to treat fevers, sore throats and cough. This study was evaluate QLOL's therapeutic effects on post infectious cough (PIC) investigate Q-markers action mechanisms by integrating pharmacokinetics network pharmacology. PIC rats were measured for frequency, organ index, pathological section of lung inflammatory factors the QLOL. Pharmacokinetic analyses performed using HPLC-QQQ-MS/MS explore possible QLOL changes...
Emerging evidence has highlighted that paraptosis may be an effective strategy for treating liver cancer. In our previous studies, Compound 4a induced in cancer cells. Here, the characteristics of 4a-induced were further revealed and, first time, target and related molecular mechanisms defined.
目的合成8-溴乙氧基大黄酸，探讨8-溴乙氧基大黄酸对肝癌HepG2.2.15细胞分泌的乙型肝炎病毒表面抗原(HBsAg)和e抗原(HBeAg)的抑制作用和机制。 方法以大黄酸为结构基础，化学全合成8-溴乙氧基大黄酸，采用红外光谱(IR)、核磁共振氢谱(1H-NMR)及碳谱(13C-NMR)对其结构进行表征；MTT法测定8-溴乙氧基大黄酸对细胞生长的抑制作用；ELISA检测HepG2.2.15细胞分泌的HBsAg和HBeAg；Western blot法检测细胞内乙肝病毒X基因(HBx)蛋白的表达；流式细胞仪分析细胞周期；激光共聚焦显微镜测定细胞内游离钙离子浓度。 结果 IR、1H-NMR和13C-NMR的结果确证合成产物为8-溴乙氧基大黄酸，合成产物和大黄酸对HepG2.2.15细胞具有较好的抑制细胞生长的作用，作用72 h后IC50分别为14.29 mg·L-1和11.59...
Background: Ischemia microenvironment contributes mostly to the low survival rate of rat bone marrow mesenchymal stem cells after transplantation. Hydrogen sulfide (H 2 S) can protect various and tissue models against apoptosis injury. Objective: To detect cell viability, content H S in supernatant, expression synthetase different time hypoxia serum deprivation cultivation cells. Methods: The passage 3 were divided into five groups: 0-, 3-, 6-, 12- 24-hour groups. After enough cultivated...