A5100414397- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- TGF-β signaling in diseases
- Computational Drug Discovery Methods
- Melanoma and MAPK Pathways
- Protein Kinase Regulation and GTPase Signaling
- Neurotransmitter Receptor Influence on Behavior
- Cancer Mechanisms and Therapy
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Protein Tyrosine Phosphatases
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience and Neuropharmacology Research
- Bioactive Compounds and Antitumor Agents
- Plant Stress Responses and Tolerance
- Lipid Membrane Structure and Behavior
- Natural product bioactivities and synthesis
- Silicon Effects in Agriculture
- Cell death mechanisms and regulation
- Aluminum toxicity and tolerance in plants and animals
- 14-3-3 protein interactions
- PI3K/AKT/mTOR signaling in cancer
- Protein Structure and Dynamics
- Sulfur Compounds in Biology
- MicroRNA in disease regulation
Sanofi (United States)
2025
Tongji University
2010-2024
Tongji Hospital
2024
Shanxi University
2024
Jinzhou Medical University
2015-2024
Henan Cancer Hospital
2024
Sichuan University
2023
Kunming University of Science and Technology
2012-2022
Wuhan University
2019-2021
China Agricultural University
2021
Abstract Previous study showed that higher expression of prolactin (PRL) was found in CRPC samples compared with hormone-naive prostate cancer (HNPC) and benign prostatic hyperplasia (BPH) samples. We further investigate the function PRL (PCa) explored its downstream effects. heterogeneous PRLR clinical The VCaP 22Rv1 cells exhibited expression. Among proteins, STAT5B dominant subtype cell lines. Human recombinant stimulation PCa resulted increased phosphorylation STAT5B(pSTAT5B) progression...
Abstract Sarilumab (interleukin‐6 receptor inhibitor) is approved in the United States and Europe for polymyalgia rheumatica (PMR). This study characterized sarilumab pharmacokinetics (PK) assessed influence of intrinsic extrinsic factors on PK patients with PMR giant cell arteritis (GCA). Exposure‐responses analyses were conducted to evaluate PK‐pharmacodynamic (PD) relationships key efficacy safety endpoints (NCT03600818). Population (Pop) analysis was using pooled data from two phase III...
Bone morphogenic proteins (BMPs) are critical for both chondrogenesis and osteogenesis. Previous studies reported that embryos deficient in Bmp receptor (Bmpr)1a or Bmpr1b cartilage display subtle skeletal defects; however, double mutant develop severe defects, suggesting a functional redundancy is essential early chondrogenesis. In this study, we examined the postnatal role of Bmpr1a cartilage. conditional knockout (cKO, cross between flox aggrecan-CreER (T2) induced by one-time-tamoxifen...
Bone morphogenetic protein 10 (BMP10) is a cardiac peptide growth factor belonging to the transforming β superfamily that critically controls cardiovascular development, growth, and maturation. It has been shown BMP10 elicits its intracellular signaling through receptor complex of activin receptor-like kinase 1 with type II or 2A. Previously, we generated characterized transgenic mouse line expressing from α-myosin heavy chain gene promoter found these mice have normal hypertrophic responses...
Hydroxycarboxylic acid receptor 2 (HCAR2), a member of Class A G-protein-coupled (GPCR) family, plays pivotal role in anti-lipolytic and anti-inflammatory effects, establishing it as significant therapeutic target for treating dyslipidemia inflammatory diseases. However, the mechanism underlying signaling HCAR2 induced by various types ligands remains elusive. In this study, we elucidate cryo-electron microscopy (cryo-EM) structure Gi-coupled complex with selective agonist, MK-6892, resolved...
An isobaric tags for relative and absolute quantitative (iTRAQ)-based proteomic approach was used to screen the differentially expressed proteins during control treatment (CK), aluminum (Al) Al+ indole-3-acetic acid (IAA) of wheat lines ET8 (Al-tolerant). Further, expression levels auxin response factor (ARF), Aux/IAA, Mitogen activated protein kinase (MAPK) 2c, MAPK1a were analyzed. Results showed that 16 determined be in Al IAA co-treatment compared with alone. Among them, MAPK2c displayed...
β-Adrenoceptors (β-ARs) play a critical role in the regulation of cardiovascular function. Intracellular oxygen homeostasis is crucial for survival cardiomyocytes. However, it still unclear whether β-AR activation can modulate intracellular oxygen. Here we used mitochondrial and cytosolic target Renilla luciferase to detect concentration. Pharmacological experiments revealed that β2-AR specifically regulates cardiomyocytes COS7 cells. This effect was abrogated by inhibitory G protein (Gi)...
PUMA (p53 unregulated modulator of apoptosis), a BH3-only Bcl-2 family member, can be induced by p53-dependent and p53-independent manners. It plays an important role as regulator cellular apoptosis. Herein, we evaluate the effects H1 (a derivative tetrandrine) on induction underlie its potential mechanism in cytotoxic response. Anti-proliferative activity evidently were observed wild-type p53 null cells. Further studies demonstrated that resulted increase cleaved PARP, decease survivin...
Aberrant activation of the Raf-MEK-ERK pathway has frequently been associated with various cancers, especially lung cancer. However, key regulators this are largely unknown. Using functional proteomics screening, we found that KAP1 interacts c-Raf. Knocking out decreased c-Raf phosphorylation at serine 259 and increased its 338, which activated MEK ERK. We detected higher expression in cancer tissues than normal peri-tumoral tissues. knockdown arrested A549 cells G0/G1 phase cell cycle...
Abstract Angiogenesis and the activation of AKT/mTOR pathway are crucial for hepatocarcinoma development progression, mTORC1/2 relevant substrates have been confirmed in clinical samples. Therefore, represents major targets anti-cancer drugs development. Here, we investigated anti-proliferative activity mechanisms ZJQ-24 hepatocellular carcinoma, both vivo vitro. A carcinoma xenograft model showed that significantly inhibited tumor growth with few side effects. MTT assays, flow cytometric...
Hepatitis E virus (HEV) is the pathogen causing hepatitis (HE). It arouses global public health concern since it a zoonotic disease. The objective of this letter to report cost-effective internal control prepared for monitoring procedures HEV reverse transcriptase (RT)-PCR detection. A selected conserved RNA fragment was integrated into downstream truncated MS2 bacteriophage genome based on Armored technology. resulting MS2-HEV gene harbored by pET-28b-MS2-HEV plasmid transformed E. coli...
Hepatocellular carcinoma (HCC) is a disease of multiple etiologies caused by the accumulation genetic and epigenetic defects. Current evidence indicates that transforming growth factor beta (TGF-β) signaling pathway has significant impact on different cellular process. Members TGF-β superfamily (TGF-β1, type I receptor [TβRI], II [TβRII], III receptor]) play an important role in tumorigenesis. Numerous studies show polymorphisms genes are associated with HCC East Asian populations. We...