A5069732713- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Melanoma and MAPK Pathways
- Protein Kinase Regulation and GTPase Signaling
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Neuropeptides and Animal Physiology
- Liver physiology and pathology
- Circadian rhythm and melatonin
- Pharmacological Effects of Natural Compounds
- Quinazolinone synthesis and applications
- Gout, Hyperuricemia, Uric Acid
- Neuroscience and Neuropharmacology Research
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Herpesvirus Infections and Treatments
- Biological and pharmacological studies of plants
- Protein Tyrosine Phosphatases
- Phytochemical compounds biological activities
- Infectious Encephalopathies and Encephalitis
- Probiotics and Fermented Foods
- TGF-β signaling in diseases
Kunming University of Science and Technology
2015-2025
Gyeongsang National University
2012-2018
Kunming Medical University
2016
First People's Hospital of Yunnan Province
2016
Kunming Children's Hospital
2016
National Institutes of Health
2011
Dictamnine (Dic), a naturally occurring small-molecule furoquinoline alkaloid isolated from the root bark of Dictamnus dasycarpus Turcz., is reported to display anticancer properties. However, little known about direct target proteins and mechanisms Dic. In current study, Dic was found suppress growth lung cancer cells in vitro vivo, attenuate activation PI3K/AKT/mTOR mitogen-activated protein kinase (MAPK) signaling pathways by inhibiting phosphorylation receptor tyrosine c-Met. Moreover,...
Summary A novel family of RGD-containing molecules (Tablysin-15) has been molecularly characterised from the salivary gland haematophagous horsefly Tabanus yao. Tablysin-15 does not share primary sequence homology to any disintegrin discovered so far, and displays an RGD motif in N-terminus molecule. It is also distinct disintegrins Viperidae since its mature form released a metalloproteinase precursor. exhibits high affinity binding for platelet αIIbβ3 endothelial cell αVβ3 integrins, but...
Lonicera japonica THUNB. , which abundantly contains polyphenols, has been used as a traditional medicine for thousands of years in East Asian countries because the anti-inflammation properties. This study aimed to investigate anti-inflammatory mechanism polyphenol components isolated from Korea L. T. by nuclear factor-kappaB (NF- κ B) and mitogen-activated protein kinases (MAPKs) pathway. Polyphenols significantly decreased lipopolysaccharide- (LPS-) induced mRNA expression inducible nitric...
Aberrant activation of the Raf-MEK-ERK pathway has frequently been associated with various cancers, especially lung cancer. However, key regulators this are largely unknown. Using functional proteomics screening, we found that KAP1 interacts c-Raf. Knocking out decreased c-Raf phosphorylation at serine 259 and increased its 338, which activated MEK ERK. We detected higher expression in cancer tissues than normal peri-tumoral tissues. knockdown arrested A549 cells G0/G1 phase cell cycle...
ABSTRACT The activation of melatonin receptors, belonging to the G‐protein coupled receptors (GPCRs) superfamily, has been recognized as a vital approach in clinical management sleep disorders. Although natural agonist and synthetic agonists (e.g., ramelteon) targeting these have extensively studied, identification compounds acting ligands remains elusive. We applied combination methods including GPCR‐induced ERK1/2 MAP kinase phosphorylation assay, inhibition forskolin‐stimulated cAMP...
Angiogenic and anti-angiogenic factors play an important role in tumor biology recurrence after surgical resection. Antiangiogenic such as vascular endothelial growth factor (VEGF)-receptor 1 (sVEGFR1) sVEGFR2, two soluble form receptor proteins of VEGF, are critical for angiogenesis. VEGF can be sequestered by forms these receptors, which result decreasing amount available to bind its on cell surface. This study aimed investigate the influences video-assisted thoracoscopic surgery (VATS)...
The serotonin receptor 5-HT 1B is widely expressed in the central nervous system and has been considered a drug target variety of cognitive psychiatric disorders. anti-inflammatory effects agonists may present promising approach for Alzheimer’s disease (AD) treatment. Herbal antidepressants used treatment AD have shown functional overlap between active compounds stimulation. Therefore, these medicinal plants that stimulate deserve careful study. Molecular docking, affinity responsive...
Activation of the histamine‐3 receptor (H3R) is involved in memory processes and cognitive action, while blocking H3R activation can slow progression neurological disorders, such as Alzheimer's disease, schizophrenia narcolepsy. To date, however, no direct way to examine has been utilized. Here, we describe a novel biosensor that visualize through an intramolecular fluorescence resonance energy transfer ( FRET ) signal. achieve this, constructed sensor with cyan fluorescent protein CFP...
The c-Met protein is a receptor tyrosine kinase involved in cell growth, proliferation, survival, and angiogenesis of several human tumors. Overexpression has been found gastric cancers correlated with poor prognosis. Indirubin the active component Danggui Longhui Wan, which traditional Chinese antileukemic recipe. In present study, we tested anti-cancer effects an indirubin derivative, LDD-1937, on cancer cells SNU-638. When performed vitro assay against activity, LDD-1937 inhibited...
Background: The Bcl2-associated athanogene4 (BAG4/SODD) protein could be identified as a tumor marker for several malignancies and plays major role in the occurrence, development, drug resistance of tumors. However, Silencer death domains (SODD) lung carcinogenesis is still elusive. Objective: To illuminate effect SODD on proliferation, migration, invasion, apoptosis cancer cells growth vivo explore corresponding mechanism. Methods: expression normal tissues was determined compared via...