A5051368568- Aluminum Alloys Composites Properties
- Advanced biosensing and bioanalysis techniques
- Magnesium Alloys: Properties and Applications
- Bacterial biofilms and quorum sensing
- Electrochemical sensors and biosensors
- Perovskite Materials and Applications
- Microbial Metabolism and Applications
- Synthesis of Organic Compounds
- Carbon and Quantum Dots Applications
- Intermetallics and Advanced Alloy Properties
- Biosensors and Analytical Detection
- Conducting polymers and applications
- MXene and MAX Phase Materials
- Nanoplatforms for cancer theranostics
- Nanocluster Synthesis and Applications
- MicroRNA in disease regulation
- Information and Cyber Security
- Aluminum Alloy Microstructure Properties
- Luminescence and Fluorescent Materials
- TGF-β signaling in diseases
- Chromatography in Natural Products
- Platelet Disorders and Treatments
- Congenital heart defects research
- Surgical site infection prevention
- Cybersecurity and Cyber Warfare Studies
Harbin University of Science and Technology
2013-2025
Ocean University of China
2021-2023
Qingdao National Laboratory for Marine Science and Technology
2021-2023
Harbin Institute of Technology
2022
Xi'an Jiaotong University
2021
Indiana University School of Medicine
2019-2021
Indiana University – Purdue University Indianapolis
2019-2021
Heilongjiang University of Science and Technology
2019
Shenyang Pharmaceutical University
2019
Harbin Medical University
2008
Abstract The RNA-binding protein QKI belongs to the hnRNP K-homology domain family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki found highly expressed in developing adult hearts. By employing human embryonic stem cell (hESC) cardiomyocyte differentiation system generating QKI-deficient hESCs (hESCs- del ) using CRISPR/Cas9 gene editing technology, we analyze physiological role differentiation, maturation,...
Bone morphogenetic protein 10 (BMP10) is a cardiac peptide growth factor belonging to the transforming β superfamily that critically controls cardiovascular development, growth, and maturation. It has been shown BMP10 elicits its intracellular signaling through receptor complex of activin receptor-like kinase 1 with type II or 2A. Previously, we generated characterized transgenic mouse line expressing from α-myosin heavy chain gene promoter found these mice have normal hypertrophic responses...
Background: Carbon dots (CDs) emitting near-infrared fluorescence were recently synthesized from green leaves. However, the Hg 2+ detection of CDs was limited because insufficient water solubility, low and poor stability. Methods: Dual emission water-soluble CD (Dual-CD) prepared through a solvothermal method holly leaves toxic PEI 1.8k . PEG further grafted onto surface to improve solubility Results: The Dual-CD solution can emit 487 nm 676 under single excitation exhibit high quantum yield...
Pseudomonas aeruginosa is an opportunistic pathogen that infects patients by regulating virulence factors and biofilms through a quorum sensing (QS) system to protect itself from antibiotics environmental stress. Therefore, the development of inhibitors (QSIs) expected become new strategy for studying drug resistance P. infections. Marine fungi are valuable resources screening QSIs. A marine fungus, Penicillium sp. JH1, with anti-QS activity was isolated offshore waters Qingdao (China),...
Quorum sensing (QS) is employed by the opportunistic pathogen Pseudomonas aeruginosa to regulate physiological behaviors and virulence. QS inhibitors (QSIs) are potential anti-virulence agents for therapy of P. infection. During screening QSIs from Chinese herbal medicines, falcarindiol (the major constituent Notopterygium incisum) exhibited inhibitory activity. The subinhibitory concentration exerted significant effects on formation biofilm production virulence factors such as elastase,...
In order to study the structure-activity relationships of xanthene derivatives, four series N-substituted 14-aryl-14H-dibenzo[a,j]xanthene-3,11-dicarboxamide derivatives were synthesized. The structures all compounds identified by 1H-NMR, HR-MS and IR spectra, in which 6a–h further 13C-NMR spectra. vitro antitumor activity synthesized was tested MTT assay. Most them displayed strong inhibitory on human hepatocellular carcinoma cell lines (SK-HEP-1, HepG2 SMMC-7721 cells) acute promyelocytic...
Background: Polycation carriers show great foreground in the developing efficient and safe gene delivery; nevertheless, they are cytotoxic unstable vivo because of excess cationic charge. PEGylation improves biocompatibility stability polycation, whereas restrains endosomal escape to some extent. Materials methods: To address this issue promote transfection vivo, a pH-sensitive conjugate folate-polyethylene glycol-carboxylated chitosan (shorten as FA-PEG-CCTS) was designed coated on surface...
Abstract Bioabsorbable sutures can improve the medical functions of existing non-absorbable sutures, and may produce new effects, are expected to become a generation degradable materials. In this study, cytocompatibility triclosan coated polyglactin910 (CTS-PLGA910) was analyzed different concentrations were prepared. The effects on cytotoxicity cell proliferation HUVEC studied by CCK-8 assay. hemolysis, total antioxidant capacity (T-AOC) activity nitric oxide (NO) content investigated blood...
AbstractA novel TiAl alloy was prepared by sintering and forging, the microstructure compression properties of sintered forged alloys were investigated. The results show that consists γ-TiAl α2-Ti3Al; in both states is divided into fine-crystal regions coarse-crystal regions, state consist slate-like γ grains with a small amount α2 grains, while equiaxed grains. few has lower porosity more homogeneous microstructure. compressive improved, strength increased from 1172 to 2349 MPa, engineering...
Abstract Magnesium alloy has excellent physical and mechanical properties is expected to become a new generation of medical degradable materials. In this paper, the blood compatibility analysis Graphene Oxide(GO) / Hydroxyapatite(HA)-AZ91D was carried out improve magnesium AZ91D used as control group GO/HA-AZ91D experimental group. The two samples were studied in vitro by hemolysis rate test, cell proliferation NO release T-AOC test. results combined with work research showed that...
Abstract A graphene oxide/hydroxyapatite(GO/HA) composite coating were prepared on the surface of fine‐grained AZ91D magnesium alloy. The morphologies and structures coatings characterized by Scanning Electron Microscopy X‐Ray Diffraction. corrosion behaviors studied polarization curve measurement alternating current impedance spectroscopy, respectively. Also, changes Mg 2+ concentration in rat plasma detected. Besides, muscle, liver, kidney rats bone rabbit tested to prove whether it was...
Language genes are supposed to be related with learning ability, and may largely determine a person's vocalization quality. In the process of utilization Single Nucleotide Polymorphisms (SNPs language gene) in personalized learning/teaching, we realized that some SNPs correlated basic parameters (including vowel/consonant) education/culture/geography/society (edu-cul-geo-soc) parameters. fact, vowel/consonant features have been approved relations local geographical factors. So it will...