A5100395045- Traditional Chinese Medicine Analysis
- Crystallization and Solubility Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Acupuncture Treatment Research Studies
- X-ray Diffraction in Crystallography
- Traditional Chinese Medicine Studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Natural Compounds in Disease Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Research and Treatments
- Cerebrospinal fluid and hydrocephalus
- Intensive Care Unit Cognitive Disorders
- Polyoxometalates: Synthesis and Applications
- Anesthesia and Sedative Agents
- Cancer, Stress, Anesthesia, and Immune Response
- Crystallography and molecular interactions
- Natural product bioactivities and synthesis
- Neurological disorders and treatments
- Healthcare and Venom Research
- Bacteriophages and microbial interactions
- Liver Disease Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Coronary Interventions and Diagnostics
Huazhong University of Science and Technology
2009-2025
Tsinghua University
2024-2025
Beijing Tsinghua Chang Gung Hospital
2024-2025
Vanderbilt University Medical Center
2021-2025
Washington University in St. Louis
2019-2025
Eye & ENT Hospital of Fudan University
2025
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Fudan University
2024
Sun Yat-sen University
2017-2024
Type 2 diabetes is a common metabolic disorder related to insulin resistance, or deficiency of secretion, caused by decreased sensitivity and destruction islet structure function. As the second human genome, microbiota has been observed have growing relationship with in recent years. Microbiota imbalance hypothesized be involved regulation energy metabolism inflammatory immune response diabetes. The present study aimed investigate whether fecal transplantation (FMT) could alleviate symptoms...
A novel metal–organic framework [Cd3(TPT)2(DMF)2]·(H2O)0.5 (1) has been solvothermally synthesized using a new rigid unsymmetrical tricarboxylate ligand p-terphenyl-3,4′′,5-tricarboxylic acid (H3TPT). Single-crystal X-ray diffraction analysis reveals that 1 possesses three-dimensional (3D) with an alb-4,8-C2/c topology constructed by the combination of Cd–carboxylate chains and TPT linkers. The π-electron rich H3TPT enables to have excellent luminescent property. micrometer-sized compound 1′...
Recently, we marked TRIO for the first time as a candidate gene intellectual disability (ID). Across diverse vertebrate species, is well-conserved Rho GTPase regulator that highly expressed in developing brain. However, little known about specific events regulated by during brain development and its clinical impact humans when mutated. Routine diagnostic testing identified an intragenic de novo deletion of boy with ID. Targeted sequencing this over 2300 individuals ID, three additional...
The arms race between bacteria and phages has led to the development of exquisite bacterial defense systems including a number uncharacterized distinct from well-known restriction-modification CRISPR/Cas systems. Here, we report functional analyses GajA protein newly predicted Gabija system. is revealed as sequence-specific DNA nicking endonuclease unique in that its activity strictly regulated by nucleotide concentration. NTP dNTP at physiological concentrations can fully inhibit robust...
Parkinson's disease (PD) is associated with progressive degeneration of dopaminergic (DA) neurons. We report for the first time that Drosophila histone deacetylase 6 (dHDAC6) plays a critical role in protection DA neurons and formation alpha-synuclein inclusions by using PD model constructed ectopic expression human alpha-synuclein. Depletion dHDAC6 significantly enhances effects caused alpha-synuclein, namely, loss neurons, retinal degeneration, locomotor dysfunction. Expression leads to...
MicroRNAs (miRNAs) have been reported to be associated with the development of cancers. However, function miRNAs in human hepatocellular carcinoma (HCC) remains largely undefined. Here we found that overexpression miR-10a promoted migration and invasion QGY-7703 HepG2 cells vitro but suppressed metastasis vivo . Cell adhesion assays showed HCC cell-matrix adhesion, which could explain results animal experiments. The Eph tyrosine kinase receptor, EphA4 , was identified as direct functional...
A new open-framework zinc phosphate with 12-ring channels has been solvothermally synthesized by using the in situ generated methylviologen as template, which exhibits multi-photoactive properties such photochromism, photoelectricity and fluorescence.
The second methylviologen (MV)-templated zeolite JU104 exhibits interesting photochromism and thermochromism with multi-colours, as well fluorescent photoelectric properties.
Abstract The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the neurons act on and whether lateralization function occurs in is also unknown. Here, we reveal increased neural activity both sample choice phases SWM. Left (LCA3) show higher sensitivity phase during correct versus error trials compared with right (RCA3) neurons. LCA3 initiates firing prior RCA3 phase. Optogenetic suppression pyramidal disrupts only Furthermore, discover that parvalbumin (PV)...
The cholinergic antiinflammatory pathway (CAP), which terminates in the spleen, attenuates postoperative cognitive decline (PCD) rodents. Surgical patients with metabolic syndrome exhibit exaggerated and persistent PCD that is reproduced rats selectively bred for easy fatigability contain all features of (low-capacity runners (LCRs)). We compared CAP lipoxin A4 (LXA4), another inflammation-resolving LCR, its counterpart high-capacity runner (HCR) rats. Isoflurane-anesthetized LCR HCR either...
Metal–organic frameworks (MOFs)-based fluorescent sensors have attracted much attention due to their high selectivity, sensitivity, and operability. However, the poor stability of MOFs seriously limits applications in detecting toxic species water system. Herein, taking advantage chemical metal phosphonate bond, easy crystallinity carboxylate, π-conjugated benzene, a new luminescent MOF with three-dimensional network has been successfully synthesized using predesigned...
Abstract Background Dopamine and dopamine receptor D1 (DRD1), a member of the family, have been indicated to play important roles in cancer progression, but secretion hepatocellular carcinoma (HCC) effects DRD1 on HCC remain unclear. This study was designed explore contribution dopaminergic system determine relationship between prognosis patients. Methods The metabolic monitored using enzyme‐linked immunosorbent assays (ELISAs). expression detected by microarray analysis,...
Ampelopsis grossedentata (vine tea) has been used as a detoxifying beverage in China for centuries. To systematically identify its bioactive compounds, the study adopted standards-based ultra-high-performance liquid chromatography coupled with quadrupole/electrostatic field orbitrap high-resolution mass spectrometry (UPLC-Q-Exactive Orbitrap MS) analysis. The analysis was conducted under negative ion model and data were collected using Xcalibur 4.1 software package. Based on comparisons...
In mechanically ventilated patients, awareness with paralysis (AWP) can have devastating consequences, including post-traumatic stress disorder (PTSD), depression, and thoughts of suicide. Single-center data from the emergency department (ED) demonstrate an event rate for AWP factors higher than that reported operating room. However, there remains a lack on among critically ill, patients. The objective was to assess proportion ED patients experiencing investigate modifiable variables...
Chinese herb medicine (CHM) is the most commonly reported traditional (TCM) modality. This study aimed to assess prevalence and associated factors of CHM use in cancer patients southwestern China. Cancer from eleven comprehensive centers were asked complete a structured questionnaire. Of 587 available replies, 53.0% used CHM. Multiple logistic regression analysis showed that educational level, stage disease, duration since diagnosis, marital status, previous strongly with after diagnosis....
Abstract Basal cells in nasal epithelium have stemness/progenitor characters and play essential roles the epithelial remodeling polyps (NP). We investigate whether human stem/progenitor (hNESPCs) from patients with NP are inherently distinct those obtained healthy controls. Epithelial basal were isolated cultured for four passages tissues control mucosa. hNESPCs controls stained positively stem cell marker p63 KRT5 presented a consistent high Ki67 expression level over passages. In contrast,...
During corticogenesis, pituitary adenylate cyclase-activating polypeptide (PACAP; ADCYAP1) may contribute to proliferation control by activating PAC1 receptors of neural precursors in the embryonic ventricular zone. receptors, specifically hop and short isoforms, couple differentially activate distinct pathways that produce pro- or anti-mitogenic actions. Previously, we found PACAP was an signal from day 13.5 (E13.5) onward both culture vivo activated cAMP signaling through isoform. However,...
Opioid receptors have become increasingly implicated in cancer progression and long-term patient outcomes. However, the expression significance of κ-opioid receptor (KOR) hepatocellular carcinoma (HCC) remain unclear. In this study, KOR mRNA was analysed by real-time quantitative PCR 64 pairs HCC tumour tissues adjacent non-tumour tissues, protein immunohistochemistry 174 patients. We investigated correlation between clinicopathological parameters to illustrate potential prognostic HCC....