A5064699036- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Genetic Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Functional Brain Connectivity Studies
- melanin and skin pigmentation
- Neurological and metabolic disorders
- Neurogenesis and neuroplasticity mechanisms
- Obsessive-Compulsive Spectrum Disorders
- RNA regulation and disease
- Transcranial Magnetic Stimulation Studies
- Autophagy in Disease and Therapy
- Pharmaceutical Practices and Patient Outcomes
- Neurological diseases and metabolism
- Aging, Health, and Disability
- Myofascial pain diagnosis and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Hearing Loss and Rehabilitation
- Health and Well-being Studies
- Hearing Impairment and Communication
Vanderbilt University Medical Center
2017-2025
Universidad de Las Palmas de Gran Canaria
2025
Florida Atlantic University
2020
Vanderbilt University
2018
University of Milan
2018
Neurological Surgery
2018
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015-2017
Institute of Molecular Bioimaging and Physiology
2017
Resonance Research (United States)
2017
Mayo Clinic
2017
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate loss of dopaminergic neurons from substantia nigra. Our main objective was to determine correspondence between changes nigra, evident neuromelanin and iron sensitive magnetic resonance imaging (MRI), striatal innervation patients with PD. Eighteen 18 healthy control subjects were included study. Using neuromelanin-MRI, we measured volume nigra contrast-to-noise-ratio background...
To investigate the physical mechanisms associated with contrast observed in neuromelanin MRI.Phantoms having different concentrations of synthetic melanins degrees iron loading were examined on a 3 Tesla scanner using relaxometry and quantitative magnetization transfer (MT).Concentration-dependent T1 T2 shortening was most pronounced for melanin pigment when combined iron. Metal-free had negligible effect spectra. On contrary, presence iron-laden resulted decreased ratio. The or (or both)...
Stroke is a leading cause for adult disability, which in many cases causes motor deficits. Despite the developments rehabilitation techniques, recovery of upper limb functions after stroke limited and heterogeneous terms outcomes, knowledge important factors that may affect outcome therapy necessary to make reasonable prediction individual patients. In this paper, we assessed relationship between quantitative electroencephalographic (QEEG) measures chronic patients underwent robot-assisted...
Abstract A subgroup of Parkinson's disease (PD) patients treated with dopaminergic therapy develop compulsive reward‐driven behaviors, which can result in life‐altering morbidity. The mesocorticolimbic dopamine network guides reward‐motivated behavior; however, its role this treatment‐related behavioral phenotype is incompletely understood. Here, function PD who impulsive and behaviors (ICB) response to agonists was assessed using BOLD fMRI. tested hypothesis that connectivity between the...
The nigrostriatal and mesocorticolimbic dopamine networks regulate reward-driven behavior. Regional alterations to mesolimbic D2/3 receptor expression are described in drug-seeking addiction disorders. Parkinson's disease (PD) patients frequently prescribed D2-like agonist (DAgonist) therapy for motor symptoms, yet a proportion develop clinically significant behavioral addictions characterized by impulsive compulsive behaviors (ICBs). Until now, changes binding both striatal extrastriatal...
To assess white matter integrity in patients with essential tremor (ET) and Parkinson disease (PD) moderate to severe motor impairment.Sedated participants ET (n = 57) or PD 99) underwent diffusion tensor imaging (DTI) fractional anisotropy, mean diffusivity, axial radial diffusivity values were computed. White tracts defined using 3 well-described atlases. determine candidate regions that differ between groups, a bootstrapping analysis was applied the least absolute shrinkage selection...
Parkinson's disease (PD) is characterized by widespread degeneration of monoaminergic (especially dopaminergic) networks, manifesting with a number both motor and non-motor symptoms. Regional alterations to dopamine D2/3 receptors in PD patients are documented striatal some extrastriatal areas, medications that target can improve However, data regarding the combined pattern receptor binding regions limited. We studied 35 off-medication 31 age- sex-matched healthy controls (HCs) using PET...
Abstract Background Parkinson's disease (PD) and essential tremor (ET) are commonly encountered movement disorders. Pathophysiologic processes that localize to the cerebellum described in both. There limited studies investigating cerebellar structural changes these conditions, largely because of inherent challenges efficiency segmentation. Methods We applied a novel multiatlas segmentation method T1‐weighted images 282 PD 111 patients define 26 lobule volumes. The severity postural resting...
Central synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), involve alpha-synuclein accumulation dopaminergic cell loss in the substantia nigra (SN) locus coeruleus (LC). Pure autonomic failure (PAF), a peripheral synucleinopathy, often precedes central synucleinopathies. To assess early brain involvement PAF using neuromelanin-sensitive magnetic resonance imaging (NM-MRI) fluorodopa-positron emission tomography...
Background/Objectives: This study evaluated adherence to compression garments, their role in edema stabilization, and factors influencing patient compliance. Materials Methods: observational, descriptive, cross-sectional garments 92 patients with lymphedema treated at the University Hospital of Gran Canaria Dr. Negrín. In addition, sociodemographic, clinical, design-related were analyzed. The evaluation was conducted via telephone questionnaires a review medical records. Results: revealed...
Dysregulated dopamine (DA) release in the mesocorticolimbic circuit is noted Parkinson's disease (PD) patients with impulsive and compulsive behaviors (ICBs). However, effect of acute DA on mood, localization this process, phenotypic differences ICB remain unknown. We applied a placebo-controlled dextro-amphetamine (dAMPH) study 20 PD patients: 10 ICBs (PD-ICB) without (PD-C). Subjective mood experiences were measured well-described self-reported measures including Positive Negative Affect...
The aim of this study is to show the long-term effects cochlear implant as a treatment in both children and adults with acquired single-sided deafness. Observational, descriptive, cross-sectional. Tertiary referral center. 21 20 SSD. Unilateral CI. Speech detection thresholds disyllabic words test (65 dB SPL) were performed modalities azimuth (S0), signal CI side (SCI), on normal hearing (SNH). ear was masked white noise +10 threshold plugging same ear, whereas speech testing using wireless...
Abstract Background Global ischemia is the resulting effect of a cardiopulmonary arrest (CPA). Presently there no effective treatment to address neurological deficits in patients who survived CPA. Granulocyte-colony stimulating factor growth (G-CSF) with plethora beneficial effects, including neuroprotection. Clinical application human G-CSF (hG-CSF) limited due its plasma half-life 4 h. Therefore, novel approaches need be investigated that would (1) enable prolonged manifestation hG-CSF and...
Cerebrospinal fluid (CSF) and interstitial exchange have been shown to increase following pharmacologically-manipulated increases in cerebral arterial pulsatility, consistent with pulsatility improving CSF circulation along perivascular glymphatic pathways. The choroid plexus (CP) complexes produce CSF, CP activity may provide a centralized indicator of flow. We tested the primary hypothesis that elevated cortical blood volume flow, present sickle cell disease (SCD), is associated...
Abstract Voxel‐based morphometry is an established technique to study focal structural brain differences in neurologic disease. More recently, texture‐based analysis methods have enabled a pattern‐based assessment of group differences, at the patch level rather than voxel level, allowing more sensitive localization between patient populations. In this study, we propose approach identify cerebellum patients with Parkinson's disease ( n = 280) and essential tremor 109). We analyzed anatomical...
Abstract Impulsivity is inherent to behavioral disorders such as substance abuse and binge eating. While the role of dopamine in impulse behavior well established, γ-aminobutyric acid (GABA) therapies have promise for treatment maladaptive behaviors. In Parkinson disease (PD), dopaminergic can result development impulsive compulsive behaviors, this clinical syndrome shares similar pathophysiology that seen addiction, abuse, binge-eating disorders. We hypothesized PD patients a reduced...
Limbic and motor integration is enabled by a mesial temporal to cortex network. Parkinson disease (PD) characterized loss of dorsal striatal dopamine but relative preservation mesolimbic early in disease, along with changes action control. Here, we studied 47 patients PD using the Simon conflict task [18F]fallypride PET imaging. Additionally, cohort 16 participated single-blinded dextroamphetamine (dAMPH) study. Task performance was evaluated diffusion model for tasks, which allows an...