The Multidrug and toxin efflux (MATE) gene family plays crucial roles in plant growth development response to adverse stresses. This work investigated the structural evolutionary characteristics, expression profiling potential functions involved aluminium (Al) tolerance from a genome-wide level. In total, 211 wheat MATE genes were identified, which classified into four subfamilies unevenly distributed on chromosomes. Duplication analysis showed that fragments tandem repeats played main...

Solitary fibrous tumor (SFT) is a rare condition first described by Klemperer and Robin in 1931. Malignant SFTs account for approximately 80% of all SFT cases, the five-year survival malignant 81%. Few reports have management using uniportal video-assisted pneumonectomy. A 35-year-old male patient with left pulmonary was assessed preoperative three-dimensional computed tomography (3D-CT) reconstruction treated via pathological diagnosis confirmed. The 3D-CT may help to provide an appropriate...

Long non‑coding RNAs (lncRNAs) are considered to be important regulators in breast cancer. In the present study, potential mechanisms and functional roles of lncRNA PSMG3‑antisense (AS)1 were investigated vivo vitro. The relative expression levels PSMG3‑AS1 microRNA (miR)‑143‑3p determined using reverse‑transcription quantitative PCR. protein collagen type 1 alpha (COL1A1) proliferating cell nuclear antigen (PCNA) obtained western blot analysis. Bioinformatics analysis was used identify...

Alfalfa is the most widely cultivated forage legume and one of economically valuable crops in world. Its survival production are often hampered by environmental changes. However, there few studies on stress-resistance genes alfalfa because its incomplete genomic information rare expression profile data. The MYB proteins characterized a highly conserved DNA-binding domain, which large, functionally diverse, represented all eukaryotes. role plant development essential; they function diverse...

Due to the close relationship among intrinsic/extrinsic motivation, regulatory focus, and creativity revealed by previous literature, motivation may play a mediating role between focus creativity. Therefore, present study aimed investigate combining motivation. In this study, senior high school students ( n = 418) completed Regulatory Focus Questionnaire, Working Preference Inventory, Williams Creativity Assessment Packet, Kirton Adaption–Innovation Inventory. The correlation analysis showed...

Non-small cell lung cancer (NSCLC) is considered to be the primary cause of cancer-related mortalities worldwide. Paclitaxel (PTX), either as a monotherapy or in combination with other drugs, an alternative therapy for advanced NSCLC. However, resistance against PTX represents major clinical problem. This study aimed investigate role and underlying mechanism miR-4262 PTX-resistant The levels were analysed by quantitative reverse transcription polymerase chain reaction. A luciferase reporter...

Emerging evidence has demonstrated that miR-223 is critically involved in the progression of pancreatic cancer (PC); however, underlying mechanisms are not fully elucidated. In present study, we explored molecular basis miR-223-mediated tumor PC. We performed numerous approaches including MTT, FACS, transfection, RT-PCR, western blotting, Transwell, and animal studies to determine physiological role PC cells. found sister chromatid cohesion protein PDS5 homolog B (PDS5B) a direct target...

Barbaloin (Bar) has a myocardial protective effect, but its mechanism of action is uncertain. The endoplasmic reticulum stress (ERS)‑mediated apoptosis pathway serves an important role in the pathogenesis ischemia‑reperfusion injury (MIRI). Inhibiting ERS may significantly improve progression MIRI and serve prevention. Therefore, based on current knowledge ERS‑mediated cardiomyocyte cardioprotective effect Bar, purpose present study was to further evaluate potential mechanisms Bar...

// Rongjie Yu 1, 2 , Hongyu Liu Xinhe Peng Yue Cui Suqin Song Like Wang Huahua Zhang 3 An Hong and Tianhong Zhou 4 1 Institute of Biomedicine, School Life Science Technology, Jinan University, Guangzhou, Guangdong, China National Engineering Research Center Genetic Medicine, Department Medical Genetics, Guangdong Dongguan, Bioengineering, Correspondence to: Yu, email: rongjie_yu1123@163.com Keywords: vasoactive intestinal peptide receptor (VPAC1), cysteine (Cys), palmitoylation, nuclear...

(I) To categorize and quantitatively analyze pleural signs on CT of pulmonary adenocarcinoma (≤3 cm); (II) to evaluate the association between visceral invasion (VPI) adenocarcinoma.The clinical data 52 patients with 91 involved pleurae were retrospectively analyzed in one single institution. Pleural categorized into five types non-interlobar fissure pleura (group A) four interlobar B). A new parameter called indentation fraction (PIF) was firstly defined level shift.In group A, type I sign...

Cyclin-dependent kinase 2 (CDK2) has been regarded as a promising drug target for anti-tumour agents. In this study, molecular dynamics (MD) simulations and principal component (PC) analysis were used to explore binding mechanism of three inhibitors 1PU, CDK, 50Z CDK2 influences their bindings on conformational changes CDK2. The results show that yield obvious impacts internal dynamics, movement patterns addition, mechanics generalized Born surface area (MM-GBSA) was applied calculate free...

Abstract Sleep is essential for basic survival as well optimal physical and cognitive performance in both human beings animals. To investigate the effect of syringin on sleep anesthetized mice potential mechanisms, 35 male K unming were randomly divided into six experimental groups ( n = 5) one control group 5). latency duration, nitric oxide NO ) content synthase NOS activity, determined after administration. The precursor l ‐ A rginine rg) or inhibitor NG N itro‐ a methyl ester NAME was...

Non-small cell lung cancer (NSCLC) is a devastating disease with heterogeneous prognosis, and the molecular mechanisms underlying tumor progression remain elusive. Mammalian Eps15 homology domain 1 (EHD1) plays promotive role in progression, but its angiogenesis remains unknown. This study thus explored of EHD1 NSCLC. The changes were evaluated through human umbilical vein endothelial (HUVEC) proliferation, migration tube formation assays. impact on β2-adrenoceptor (β2AR) signaling was by...

Previous studies have shown the intake of omega-3 polyunsaturated fatty acids is associated with low rates obesity and ischaemic pathologies. Omega-3 also anti-inflammatory plaque-stabilization effects regulate vasodilation constriction. However, there are few role in flow-induced involving Ca2+-permeable ion channel TRPV4 high-fat diet-induced obese (DIO) mouse. Here, we determined whether protect against vascular dysfunction induced by a diet enhancing activity subsequently improving...

Abstract Background The aim of this study was to investigate the circ_0004370 expression in EC, its effects on cell proliferation, apoptosis, migration, invasion, and epithelial–mesenchymal transition (EMT) process, underlying regulatory mechanisms EC. Methods protein levels COL1A1 EMT-related proteins were detected by western blot. role viability, apoptosis analyzed Cell Counting Kit-8 (CCK-8) assay, colony formation flow cytometry, respectively. transwell assay used examine migration...

Great quantity of intergenic noncoding RNAs (lncRNAs) have been identified in the mammalian genome and involved various biological processes, especially development metastasis cancer. In this study, we one lncRNA, lncRNA NONHSAT028712 (Lnc712), was highly expressed breast cancer cell lines tissues based on microarray screening. Knockdown Lnc712 largely inhibited proliferation. Mechanistically, bound specifically to heat-shock protein 90 (HSP90). Interaction between HSP90 is required for...

14-3-3ζ is involved in tumor cell growth and apoptosis. However, the mechanism of lung squamous carcinoma (SCC) metastasis has not been illuminated. In our studies, we found that expression was highly expressed SCC compared to normal tissues. High associated with pTNM stage (p<0.05) lymph node (p<0.05). Furthermore, protein high levels TGFβR1 (p=0.005), pSMAD3 (p=0.033). Lung patients have significantly shorter OS DFS low expression. Additionally, knockdown inhibited proliferation, migratory...