A5100403431- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Ear Surgery and Otitis Media
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Geomechanics and Mining Engineering
- Bone fractures and treatments
- Spinal Fractures and Fixation Techniques
- Vestibular and auditory disorders
- Molecular Biology Techniques and Applications
- Nitrogen and Sulfur Effects on Brassica
- Prostate Cancer Treatment and Research
- Advanced MRI Techniques and Applications
- Medicinal Plant Pharmacodynamics Research
- Ubiquitin and proteasome pathways
- Air Quality and Health Impacts
- Immune cells in cancer
- Cardiac Valve Diseases and Treatments
- Carcinogens and Genotoxicity Assessment
Army Medical University
2025
Southwest Hospital
2025
First Affiliated Hospital of Zhengzhou University
2011-2024
Xiangya Hospital Central South University
2023
Central South University
2023
Capital Medical University
2015-2022
Shantou University Medical College
2016-2022
Beijing Anzhen Hospital
2021-2022
Hebei Medical University
2021-2022
Fourth Hospital of Hebei Medical University
2022
Abstract Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression, but the absorption mechanism remains unknown. Here, we show that SIDT1 expressed on gastric pit cells in stomach is required for of dietary microRNAs. SIDT1-deficient mice reduced basal levels impaired dynamic Notably, identified as primary site microRNA absorption, which dramatically attenuated stomachs mice. Mechanistic analyses revealed uptake exogenous low-pH dependent. Furthermore,...
MicroRNAs are small, approximately 21- to 24-nt RNAs that have been found regulate gene expression. miR-206 is a microRNA expressed at high levels in Drosophila, zebrafish, and mouse skeletal muscle thought be involved the attainment and/or maintenance of differentiated state. We used locked nucleic acid probes for situ hybridization analysis intracellular localization during differentiation rat myogenic cells. Like most microRNAs, which presumed suppress translation target mRNAs, we...
microRNAs (miRNAs) are short 20- to 22-nucleotide noncoding RNAs that negatively regulate the expression of target genes at post-transcriptional level. The specific miRNAs and their roles in osteogenic differentiation human periodontal ligament stem cells (PDLSCs) exposed mechanical stretch remain unclear. Here, we found induced both differential miR-21 PDLSCs. Furthermore, identified activin receptor type IIB (ACVR2B) as a gene miR-21. Luciferase reporter assays showed interacts directly...
Abstract Apoptosis is an important mechanism for the development of heart failure. Mitochondria are central to execution apoptosis in intrinsic pathway. The main regulator mitochondrial pathway Bcl‐2 family which includes pro‐ and anti‐apoptotic proteins. Micro RNA s small noncoding molecules that regulate gene expression by inhibiting mRNA translation and/or inducing degradation. It has been proposed micro play critical roles cardiovascular physiology pathogenesis diseases. Our previous...
Abstract Metabolic reprogramming of tumor cells dynamically reshapes the distribution nutrients and signals in microenvironment (TME), affecting intercellular interactions resulting metabolic immune suppression. Increased glucose uptake metabolism are characteristic many tumors. Meanwhile, progression colorectal carcinoma (CRC) relies on lipid metabolism. Therefore, investigating role glucolipid immunity contributes to identifying new targets for suppression intervention CRC. Our previous...
Conclusion Vestibular function in patients can be damaged following cochlear implantation. Therefore, assessing the pre-operative vestibular status, carefully choosing side of implantation, and preserving by using minimally invasive surgical techniques are important. Objectives The aim this study was to assess influence implantation on with severe profound sensorineural hearing loss, analyze a possible correlation between changes testing post-operative symptoms. Methods Thirty-four were...
MicroRNAs (miRNAs) are critical regulators of gene expression, and they have broad roles in the pathogenesis different diseases including cancer.Limited studies expression profiles miRNAs available human osteosarcoma cells.By applying a miRNA microarray analysis, we observed number with abnormal cancerous tissues from patients.Of particular interest this study was miR-449c, which significantly downregulated cells patients, its negatively correlated tumor size MSTS stages.Ectopic miR-449c...
Emerging evidence has demonstrated that miR-223 is critically involved in the progression of pancreatic cancer (PC); however, underlying mechanisms are not fully elucidated. In present study, we explored molecular basis miR-223-mediated tumor PC. We performed numerous approaches including MTT, FACS, transfection, RT-PCR, western blotting, Transwell, and animal studies to determine physiological role PC cells. found sister chromatid cohesion protein PDS5 homolog B (PDS5B) a direct target...
Previous studies reported that the expression of miR-23b-27b cluster was downregulated in embryonic brain cortices during hypoxia-induced neuronal apoptosis. However, mechanism underlying this downregulation is not completely understood. Here, we report transcription factor c-Myc plays an important role regulating hypoxia. First, protein level significantly elevated a mouse model fetal distress. Second, forced overexpression or knockdown could suppress increase polynucleotides. Third,...
The present study provided the first in vivo evidence that Ses pretreatment potentially represents a novel and pragmatic therapeutic strategy to protect cardiovascular system from damage via its anti-ferroptosis activity.
Background: Cerebrospinal fluid (CSF) is in contact with brain parenchyma and ventricles, its composition might influence the cellular physiology of oligodendrocyte progenitor cells (OPCs) thereby contributing to multiple sclerosis (MS) disease pathogenesis. Objective: To identify transcriptional changes that distinguish response induced proliferating rat OPCs upon exposure CSF from primary progressive (PPMS) or relapsing remitting (RRMS) patients other neurological controls. Methods: We...
MicroRNAs (miRNAs) serve as important regulators of the tumorigenesis and progression many human cancers. Therefore, we evaluated biological function underlying mechanism miR-363 in clear cell renal carcinoma (ccRCC).The expression ccRCC tissues compared with adjacent normal was detected by quantitative real-time polymerase chain reaction, association between levels prognosis patients analyzed. The candidate target gene determined silico analysis luciferase reporter assays. effects on...
MiR-181 expression levels increased in hepatocellular carcinoma (HCC) compared to non-cancerous tissues. has been widely reported as a possible driver of tumourigenesis but also acts tumour suppressor. In addition, the miR-181 family regulates development and function immune vascular cells, which play vital roles progression tumours. More complicatedly, many genes have identified targets mediate effects miR-181. However, role primary tumours remains largely unexplored. We aimed examine its...
MicroRNAs (miRNAs) have been revealed to play a crucial role in oncogenesis of esophageal squamous cell carcinoma (ESCC). However, the biological miR-181a-5p ESCC is currently less explored. The current study was designed assess whether affects progression and further investigate relevant underlying mechanisms. Based on data GSE161533, GSE17351, GSE75241 GSE67269 downloaded from GEO database, MAP2K1 (MEK1) be one overlapping gene top 300 DGEs. Additionally, using predicting software,...
Endogenous and exogenous tumor-related microRNAs (miRNAs) are considered promising tumor biomarkers therapeutic agents. In this work, we propose a miRNA self-responsive drug delivery system (miR-SR DDS), which enables the association between endogenous miRNAs, so as to achieve smart responsive synergistic delivery. The miR-SR DDS consists of DNA-miRNA hybrids let-7a complementary DNA miR-155, was packaged in exosomes. response overexpressed miR-155 breast cancer cells, disintegrate release...
Obesity was a recognized risk factor for the development and progression of hepatocellular carcinoma (HCC). However, effects mechanisms by which obesity promotes HCC metastasis remain poorly understood.We cultured adipocyte induced preadipocyte 3T3-L1 in vitro established model mouse vivo to mimic tumor microenvironment obese status. The underlying obesity-associated miR-27a upregulation promoting were investigated.In this study, we showed that upregulated adipocytes, clinical samples,...
The present study aimed to explore microRNA-126 (miR-126) as a novel therapeutic target for primary hypertension. lentiviral vector containing human immunodeficiency virus 1 (HIV‑1), the miR‑126 gene knockdown viral (lenti-miR-126-KD), and control (lenti‑scramble‑miR) were constructed. Spontaneously hypertensive rats randomly divided into 4 groups, which received high dose of lenti‑miR‑126‑KD (1x108, n=5), low (1x107, n=6), scramble‑miR (5x107, PBS (n=6). Lentiviral vectors injected tail...