A5037521710- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Ultrasound and Hyperthermia Applications
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
Army Medical University
2022-2025
Southwest Hospital
2023-2025
Abstract Liver metastasis is the major reason for most of colorectal cancer (CRC) related deaths. Accumulating evidence indicates that CRC patients with non-alcoholic fatty liver disease (NAFLD) are at a greater risk developing metastasis. With growing prevalence NAFLD, better understanding molecular mechanism in NAFLD-driven needed. In this study, we demonstrated NAFLD facilitated as metabolic disorder and promoted stemness metastatic cells their colonization outgrowth hepatic niches....
The poor immunogenicity of solid tumors limits the efficacy ofanti-programmed cell death protein 1 (anti-PD1)-based immune checkpoint blockade (ICB); thus, less than 30% patients with cancer exhibit a response. Currently, there is still lack effective strategies for improving tumor immunogenicity.The antitumor effect ultrasound-stimulated nanobubbles (USNBs) alone and in combination an anti-PD1 antibody was evaluated RM1 (prostate cancer), MC38 (colon cancer) B16 (melanoma) xenograft mouse...
Abstract Metabolic reprogramming of tumor cells dynamically reshapes the distribution nutrients and signals in microenvironment (TME), affecting intercellular interactions resulting metabolic immune suppression. Increased glucose uptake metabolism are characteristic many tumors. Meanwhile, progression colorectal carcinoma (CRC) relies on lipid metabolism. Therefore, investigating role glucolipid immunity contributes to identifying new targets for suppression intervention CRC. Our previous...
Resistance to sorafenib, an effective first-line treatment for advanced hepatocellular carcinoma (HCC), greatly compromised the prognosis of patients. The extracellular matrix is one most abundant components tumor microenvironment. Beyond acting as a physical barrier, it remains unclear whether cell interactions and signal transduction mediated by contribute sorafenib resistance. With analysis primary HCC organoid RNA-seq data combined with in vivo vitro experiments validation, we discovered...