A5016615241- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Treatments and Studies
- Appendicitis Diagnosis and Management
- CAR-T cell therapy research
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Chemical Reactions and Isotopes
- Hernia repair and management
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Health and Medical Research Impacts
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Gastrointestinal disorders and treatments
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Intestinal and Peritoneal Adhesions
Dandenong Hospital
2021-2025
Monash Health
2021-2025
Alfred Health
2025
Memorial Sloan Kettering Cancer Center
2023
Monash University
2021-2023
Australia and New Zealand Banking Group
2023
The University of Melbourne
2016-2022
Peter MacCallum Cancer Centre
2014-2022
Royal Prince Alfred Hospital
2020
Austin Hospital
2020
Abstract Purpose: Patients with colorectal cancer peritoneal metastases (CRPMs) have limited treatment options and the lowest survival rates. We aimed to determine whether organoid testing could help guide precision for patients CRPMs, as clinical utility of prospective, functional drug screening including nonstandard agents is unknown. Experimental Design: CRPM organoids (peritonoids) isolated from underwent parallel next-generation sequencing medium-throughput panel ex vivo identify...
Abstract Chimeric antigen receptor (CAR) T-cell therapy has proven successful in the treatment of hematological malignancies, notably acute lymphoblastic leukemia and B-cell lymphoma. However, efficacy CAR T cells against solid tumors is poor, likely due to tumor-associated immunosuppression. Here, we demonstrated that antagonizing “inhibitor apoptosis proteins” with clinical smac-mimetic, birinapant, significantly enhanced antitumor activity a tumor necrosis factor (TNF)-dependent manner....
Purpose The presence of tumor-infiltrating lymphocytes (TILs) in tumors is superior to conventional pathologic staging predicting patient outcome. However, their does not define TIL functionality. Here we developed an assay that tests cytotoxicity patients with locally advanced rectal cancer before definitive treatment, identifying those who will obtain a complete response (pCR). We also used the demonstrate rescue function after checkpoint inhibition blockade (CIB). Patients and Methods...
The overall decline in colorectal cancer (CRC) incidence developed nations is overshadowed by a worrying anomaly: rise young-onset (YO-CRC), broadly accepted as CRC diagnosed patients under the age of 50. Currently, about 10–12% all new diagnoses are 50.1, 2 Projections suggest that 2030, YO-CRC would account for quarter rectal cancers.3 Additionally, projected to become leading cause related mortality those aged 20–49 2030.4 Locally, Australia and New Zealand have some highest standardized...
Soft tissue infections are a major health burden in the Top End of Northern Territory Australia. Necrotizing fasciitis (NF) is associated with mortality rates from 8 to 40%. Early recognition and aggressive surgical debridement cornerstones successful treatment. The Laboratory Risk Indicator for Fasciitis (LRINEC) score, developed by Wong et al., uses six routine biochemical variables aid early diagnosis. We aim assess diagnostic efficacy LRINEC score our population.A retrospective review...
Colorectal cancer is the second leading cause of cancer-related mortality worldwide. Peritoneal metastases carry worst prognosis among all sites colorectal metastases. In recent years, advent and acceptance cytoreductive surgery hyperthermic intraperitoneal chemotherapy have greatly improved survival for selected patients with low-volume peritoneal metastases.Here, we report evolution at a statewide tertiary referral center over an 8-year period.This retrospective study from 2009 to 2017.The...
Right hemicolectomy is a common colorectal operation for resection of cancers the right colon. The ileocolic anastomosis may be created using stapled end-to-side, side-to-side or handsewn technique. Anastomotic leak and post-operative bleeding are uncommon but serious causes morbidity mortality, while ileus contributes to prolonged length stay. aim this study was evaluate differences in short-term outcomes between different anastomotic configurations following colon cancer.We conducted...
Anastomotic leaks (AL) and surgical site infections (SSI) are serious complications after colorectal resection. Studies have shown the benefits of pre-operative oral antibiotics (OAB) with mechanical bowel preparation (MBP) in reducing AL SSI rates. We aim to investigate our experience short-term outcomes following elective resections patients receiving OAB MBP versus only.A retrospective analysis was performed from database for who underwent resection between January 2019 November 2021....
Abstract Aim Robotic transanal minimally invasive surgery (R‐TAMIS) is gaining traction around the globe as an alternative to laparoscopic conventional TAMIS for local excision of benign and early malignant rectal lesions. The aim was analyse patient oncological outcomes R‐TAMIS consecutive cases in a single centre. Methods A prospective analysis procedures over 12‐month period performed. Data were collated from hospital databases theatre registers. Results Eleven patients (six men, five...
Abstract Objectives Tumor‐infiltrating lymphocytes (TIL), particularly CD8 + TILs in patients with colorectal cancer (CRC), are highly prognostic the early‐disease stages (I‐II). In metastatic disease (stage IV; mCRC), their influence is less well defined. It has presumably failed to contain tumor cells primary site; however, this evident? We explored impact of at site who presented de novo mCRC. Methods Treatment‐naïve (109) mCRC were assessed for and PD‐L1 expression. Microsatellite...
Abstract Vaginal evisceration is a rare condition where abdominal contents herniate through vaginal wall defect. The estimated incidence 0.032–1.2% after hysterectomy, trachelectomy or upper vaginectomy. We present 78-year-old lady who developed 2 years radical cystectomy and hysterectomy for bladder cancer. It surgical emergency that requires prompt recognition damage control with bowel reduction packing. discuss the initial management options definitive repair.