A5044396195- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Intraperitoneal and Appendiceal Malignancies
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Appendicitis Diagnosis and Management
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Hernia repair and management
- Urological Disorders and Treatments
- Frailty in Older Adults
- Abdominal Trauma and Injuries
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Silkworms and Sericulture Research
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Intestinal and Peritoneal Adhesions
- Ovarian cancer diagnosis and treatment
- Science, Research, and Medicine
Peter MacCallum Cancer Centre
2019-2024
The University of Melbourne
2019-2024
The Alfred Hospital
2023-2024
Auckland City Hospital
2023
Clinical Trials New Zealand
2021
Society of Surgical Oncology
2019
Abstract Background The gold standard treatment for locally advanced rectal cancer is total mesorectal excision after preoperative chemoradiotherapy. Response to chemoradiotherapy varies, with some patients completely responding the and failing respond at all. Identifying biomarkers of response could allow avoid unnecessary treatment-associated morbidity rate. While previous studies have attempted identify such biomarkers, none reached clinical utility, which may be due heterogeneity cancer....
3616 Background: Neoadjuvant long course chemoradiotherapy (LCCRT) for locally advanced rectal cancer (LARC) results in a complete pathological response rate 10-30% of patients (pts), but with 20-40% non-responders and 10-15% have local recurrence. Radiotherapy (RT) is immuno-stimulatory by enhancing local/distant tumour cell death, also immunosuppressive as it stimulates PDL1 production myeloid-derived suppressor activity. Hence inhibition may be required to enhance the effects RT....
TPS3622 Background: Standard neoadjuvant long course chemoradiotherapy (LCCRT) for locally advanced rectal cancer (LARC) results in a complete pathological response rate of 10-30%: but 20-40% patients (pts) are non-responders, 10-15% have local recurrence. Tumoural immune infiltrates predictive response. Preclinical studies show that radiotherapy (RT) via interferon signaling is immuno-stimulatory, enhancing local/distant tumour cell death. RT also stimulates PDL1 production and the...
A 47-year old male initially presented with rectal bleeding and was subsequently diagnosed a poorly differentiated adenocarcinoma at 5cm from the anal verge in July 2016.The patient completed neo-adjuvant long-course chemoradiotherapy (50.4Gy/28f, 5FU), followed by laparoscopic ultralow anterior resection defunctioning loop ileostomy January 2017.
Cancer is a major health burden and expected to rank as the leading cause of death in every country 21st century.1 Despite extensive research advances cancer care, there significant limitation translation bench bedside treatments, largely due nature current models used research. Current include cell lines mouse xenografts (PDXs). are two-dimensional cells grown vitro. They have variable success establishment, often undergo substantial vitro genetic changes fail recapitulate heterogeneity...
Abstract Background: Colorectal cancer (CRC) is the third most common worldwide. Up to half patients with CRC will develop metastatic disease, an associated 5-year survival of 13.5%. The peritoneum a site for metastases, but carries worst prognosis among all sites. Most colorectal peritoneal metastases (CRPM) are inoperable, leaving systemic chemotherapy as only treatment option. With therapy alone, 4% CRPM alive at 5 years. Immunotherapy, while effective in number cancers, remains...
Foreign body ingestions are common in medicine and typically cause pain which often requires prompt identification removal.1 We present imaging specimen photography of a 59-year-old female who had bobby pin embedded her bowel for 20 years. The patient presented to the emergency department with acute on chronic abdominal pain, recalling two decades crampy episodes localized left lower quadrant. Additionally, she reported longstanding constipation, defecation intermittent dyspareunia. previous...
Littoral cell angiomas are uncommon primary splenic haemangiomas with rare malignant potential. We report a case of 76-year-old male an incidental solitary littoral angioma found within accessory spleen. provide overview the literature and highlight diagnostic challenge treatment this important differential for general surgeons caring patients masses. This is first to describe resection preservation.
BackgroundColorectal cancer (CRC) is the second leading cause of related mortality. Over 80% CRC develop from adenomatous polyps. Hence, early treatment and prevention adenomas would lead to a significant decrease disease burden for CRC. MYB transcription factor that over-expressed in both polyp precursors colorectal hence an ideal immunotherapeutic target. We have developed vaccine, TetMYB, targets aim evaluate its efficacy prophylactic therapeutic management polyps.Material MethodsSix...
was a landmark event with subsequent explosion in the field of genomics.Despite fanfare, sixteen years on genomics has failed to deliver expected revolutions cancer therapy, heralding false dawn which not materialised into clinical utility.In order predict next
Abstract Background Colorectal cancer (CRC) is the second leading cause of related mortality. Over 80% CRC develop from adenomatous polyps. Hence, early treatment and prevention adenomas would lead to a significant decrease disease burden for CRC. MYB transcription factor that over-expressed in both polyp precursors colorectal hence an ideal immunotherapeutic target. We have developed vaccine, TetMYB, targets aim evaluate its efficacy prophylactic therapeutic management Material Methods Six...